1.
Angew Chem Int Ed Engl
; 54(44): 13002-6, 2015 Oct 26.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26368132
RESUMEN
Heat-induced radiolabeling (HIR) yielded (89) Zr-Feraheme (FH) nanoparticles (NPs) that were used to determine NP pharmacokinetics (PK) by positron emission tomography (PET). Standard uptake values indicated a fast hepatic uptake that corresponded to blood clearance, and a second, slow uptake process by lymph nodes and spleen. By cytometry, NPs were internalized by circulating monocytes and monocytes inâ vitro. Using an IV injection of HIR (89) Zr-FH (rather than inâ vitro cell labeling), PET/PK provided a view of monocyte trafficking, a key component of the immune response.