RESUMEN
OBJECTIVE: The morphological analysis of trabecular bone of the distal epiphysis of the radius and its three-dimensional representation allow an adequate evaluation of bone quality. We analyzed trabecular bone morphology and its three-dimensional modeling with high resolution magnetic resonance imaging (MRI) to determine the parameters that provide useful information about bone condition. MATERIAL AND METHODS: All data were acquired using 3D T1-weighted gradient-echo sequences in a 3-Tesla MRI scanner. The mathematical algorithms required to study trabecular bone structure were developed in a Matlab environment on a personal computer. A total of 16 healthy subjects (10 women and 6 men; aged 23 to 54 years, mean 36+/-10 years) were studied. No significant differences were found between women (mean age 39+/-12, range: 23-54 years) and men (mean age 33+/-6, range: 25-42) (p = 0.285). Healthy subjects were recruited from among normal subjects studied to assess the ligaments of the wrist. The morphological parameters analyzed were trabecular volume, mean trabecular thickness, mean trabecular separation, and trabecular index. RESULTS: The morphological parameters that were useful in the evaluation of bone quality were trabecular volume (women: 23.22+/-1.78%; men: 27.49+/-1.30%), trabecular thickness (women: 0.1901+/-0.0014 mm; men: 0.1935+/-0.0014 mm), trabecular separation (women: 0.8332+/-0.0440 mm; men: 0.7697+/-0.0258 mm), and the number of trabeculae (women: 1.2215+/-0.0920 mm-1; men: 1.4207+/-0.0640 mm-1). Statistically significant differences between men and women were found for all the parameters analyzed; no significant differences were found in relation with age in this series. CONCLUSIONS: High resolution MRI enabled the morphological characterization of the trabecular bone structure; this represents an advance in the detection of biomarkers for disease.
Asunto(s)
Huesos/anatomía & histología , Imagen por Resonancia Magnética , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Objetivo. El análisis morfológico de la estructura trabecular de la epífisis distal del radio y su representación 3D evalúa adecuadamente la calidad del hueso. Nuestro objetivo es presentar un análisis de la morfología trabecular ósea y su modelización 3D con resonancia magnética (RM) de alto campo para detectar aquellos parámetros que proporcionan información relevante sobre el estado del hueso. Material y métodos. Todas las adquisiciones se realizaron con una secuencia 3D eco de gradiente potenciada en T1 en un equipo de RM de 3 Teslas. Se desarrollaron sobre PC en entorno Matlab los algoritmos matemáticos necesarios para estudiar la estructura trabecular ósea. Se analizaron 16 sujetos sanos (10 mujeres y 6 hombres) en un rango de edades de 23 a 54 años, siendo la edad media de 36 años ± 10 (desviación estándar). No hubo diferencias significativas (p = 0,285) entre mujeres (edad media de 39 años ± 12; rango: 23-54) y hombres (edad media de 33 años ± 6; rango: 25-42). Los casos analizados se corresponden con sujetos normales a los que se les realizaba la adquisición para valoración ligamentosa de la muñeca. Los parámetros morfológicos analizados se corresponden con el volumen trabecular, el grosor trabecular medio, la separación trabecular media y el índice trabecular. Resultados. Los parámetros morfológicos relevantes para evaluar la calidad del hueso son el volumen trabecular (mujeres: 23,22 ± 1,78%; hombres: 27,49 ± 1,30%), el espesor trabecular (mujeres: 0,1901 ± 0,0014 mm; hombres: 0,1935 ± 0,0014 mm), la separación trabecular (mujeres: 0,8332 ± 0,0440 mm; hombres: 0,7697 ± 0,0258 mm) y el número trabecular (mujeres: 1,2215 ± 0,0920 mm-1; hombres: 1,4207 ± 0,0640 mm-1). Todos los parámetros analizados fueron estadísticamente diferentes entre mujeres y hombres, no existiendo diferencias significativas con la edad en esta serie. Conclusiones. En este estudio se evidencia que la RM de alta resolución permite la caracterización morfológica de la estructura trabecular ósea y supone un avance en la detección de biomarcadores de la enfermedad (AU)
Objective. The morphological analysis of trabecular bone of the distal epiphysis of the radius and its three-dimensional representation allow an adequate evaluation of bone quality. We analyzed trabecular bone morphology and its three-dimensional modeling with high resolution magnetic resonance imaging (MRI) to determine the parameters that provide useful information about bone condition. Material and methods. All data were acquired using 3D T1-weighted gradient-echo sequences in a 3-Tesla MRI scanner. The mathematical algorithms required to study trabecular bone structure were developed in a Matlab environment on a personal computer. A total of 16 healthy subjects (10 women and 6 men; aged 23 to 54 years, mean 36±10 years) were studied. No significant differences were found between women (mean age 39±12, range: 23-54 years) and men (mean age 33±6, range: 25-42) (p = 0.285). Healthy subjects were recruited from among normal subjects studied to assess the ligaments of the wrist. The morphological parameters analyzed were trabecular volume, mean trabecular thickness, mean trabecular separation, and trabecular index. Results. The morphological parameters that were useful in the evaluation of bone quality were trabecular volume (women: 23.22±1.78%; men: 27.49±1.30%), trabecular thickness (women: 0.1901±0.0014 mm; men: 0.1935±0.0014 mm), trabecular separation (women: 0.8332±0.0440 mm; men: 0.7697±0.0258 mm), and the number of trabeculae (women: 1.2215±0.0920 mm-1; men: 1.4207±0.0640 mm-1). Statistically significant differences between men and women were found for all the parameters analyzed; no significant differences were found in relation with age in this series. Conclusions. High resolution MRI enabled the morphological characterization of the trabecular bone structure; this represents an advance in the detection of biomarkers for disease (AU)