The Common Retention Practices Among Orthodontists from Different Countries.

Objective: To investigate the most common retention practices, factors influencing the retention protocol, and the differences among orthodontists regarding retention practices. Methods: An online validated questionnaire was anonymously sent to 3,000 orthodontic residents and clinicians. The survey consisted of 19 questions regarding the participants' demographics, prescribed retention appliances, factors affecting retention appliance choices, and adjunctive retention procedures. Descriptive statistics, Chi2 and Kendall's Tau-b tests were applied. Results: Five hundred fifty-five orthodontic residents and clinicians, 53.3% males and 46.7% females, completed the survey, indicating a response rate of 18.5%. Although participants' demographics, type of treatment and pre-treatment malocclusion influence the choice of retention protocols, thermoplastic retainers (TR) were the most popular retention regime for the maxillary arch for both adults (47.4%) and adolescents (42.3%). Bonded retainers (BR) were the favored option for the mandibular arch (44.9% of adults and 40.7% of adolescents). The degree of arch expansion (64.1%) and the degree of interdigitation (50.1%) after treatment were the most influential factors for the choice of the preferred type of retainers by the respondents. 68.6% of the participants thought professional retention guidelines would be useful. Conclusion: Thermoplastic retainers were the most common retention appliances for adults and adolescents in the maxilla. At the same time, BR was the most favored retainer in the mandibular arch, with clinical experience, practice setting, and malocclusion- and treatment-related factors influencing the type of the chosen appliance. The demographic differences and the uneven participation in the survey need to be considered while interpreting the findings of this study.

Accuracy and reproducibility of tablet-based applications for three-dimensional facial scanning: an in-vitro study.

AIM: An in-vitro study was performed to investigate the overall and regional accuracy and precision of digital three-dimensional facial scans obtained from four tablet-based applications (Bellus Dental Pro, Capture: 3D scan anything, Heges, and Scandy Pro 3D scanner) on an iPad Pro® (Apple Store, Cupertino, CA, USA), equipped with LiDAR and TrueDepth technology, compared to the validated manual measurements using a digital vernier caliper (DVC). MATERIALS AND METHODS: The accuracy of the various applications was determined through multiple scans of a three-dimensional (3D) printed mannequin face using iPad Pro®. For precision evaluation, the mannequin's face was scanned five times with each application, and these models were compared using the coefficient of variation (CV). The descriptive statistics were done from SPSS version 23 (IBM Company, Chicago, USA). One-sample t-test was used to analyze the difference between the control and the various scans. RESULTS: While the applications Capture, Heges, and Scandy tended to overestimate the measured values compared to DVC, the Bellus application underestimated these values. Scandy showed the highest mean difference in the Go - Ch (R) measurement, with a value of 2.19 mm. All the others average differences were less than 1.60mm. The assessment of precision showed that the coefficient of variation ranged from 0.16% and 6.34%. CONCLUSION: The iPad Pro® (2020) showed good precision and reasonable reliability, and it appears to be an interesting and favorable technology for the acquisition of surface images of facial-like structures. Moreover, further clinical investigations should be conducted.

Accuracy (trueness and precision) of four tablet-based applications for three-dimensional facial scanning: An in-vitro study.

OBJECTIVES: This study aimed to investigate the overall and regional accuracy (trueness and precision) of digital three-dimensional (3D) facial scans obtained from four tablet-based applications, which were (Bellus) the Bellus Dental Pro® (Bellus3D, Inc. Campbell, CA, USA), (Capture) the Capture®: 3D Scan Anything (Standard Cyborg, Inc. San Francisco, CA, USA), (Heges) the Heges® (by Marek Simonik, Ostrava, North Moravia, Czech Republic), and (Scandy) the Scandy Pro 3D Scanner® (Scandy LLC, New Orleans, LA, USA). METHODS: A mannequin's face was marked with 63 landmarks. Subsequently, it was scanned 5 times using each scan application on an iPad Pro® (Apple Inc., Cupertino, CA, USA). The digital measurements were obtained with MeshLab® (CNR-ISTI, Pisa, Tuscany, Italy) and compared to the manual measurements using a digital vernier calliper (Truper Herramientas S.A., Colonia Granada, Mexico City, Mexico). The absolute mean difference and the standard deviation of the dimensional discrepancies were calculated. Moreover, the data were analysed by using one-way ANOVA, Levene's test, and Bonferroni´s correction. RESULTS: The absolute mean trueness values were Bellus 0.41 ± 0.35 mm, Capture 0.38 ± 0.37 mm, Heges 0.39 ± 0.38 mm, and Scandy 0.47 ± 0.44 mm. Moreover, precision values were Bellus 0.46 mm, Capture 0.46 mm, Heges 0.54 mm, and Scandy 0.64 mm. Comparing the regions, Capture and Scandy showed the highest absolute mean difference, which was 0.81 mm in the Frontal and Zygomaticofacial regions, respectively. CONCLUSIONS: The trueness and precision of all four tablet-based applications were clinically acceptable for diagnosis and treatment planning. CLINICAL SIGNIFICANCE: The future of the three-dimensional facial scan is auspicious, and it has the potential to be affordable, accurate, and of great value for clinicians in their daily practice.

Global survey to assess preferences for attending virtual orthodontic learning sessions: Pre-webinar settings.

OBJECTIVES: To assess technical factors and audience preferences before attending orthodontic online learning activity, the demand for which increased dramatically in the era of the COVID-19 pandemic. DESIGN: Cross-sectional study. SETTING: Online survey. PARTICIPANTS: Global orthodontic residents and specialists. METHODS: A validated and anonymous survey comprising 17 online questions was sent to 3000 individuals. The data were collected three months later. Descriptive statistics and non-parametric tests were applied. RESULTS: The participants' response rate was 19.9%, with almost equal gender participation. Most of the responders were based in Asia (51.4%). Almost half of the participants were aged 25-35 years with less than 5 years of clinical experience. Regardless of the age, gender or global distribution, 57.3% of respondents opted to share limited personal information with the host. One-third of the respondents preferred receiving webinar reminders via email, ideally a day and/or one hour before the webinar, especially being exportable to their calendars. Age played a major role in shaping this trend, as young participants favoured the one hour (1-h) pre-webinar reminder more than other age groups (P=0.02). Receiving information about the speaker, learning outcomes and pre-webinar reading material (WRM) were preferable, particularly among young participants in comparison with the older age groups (P<0.05). Male participants from Asia and Africa preferred to attend online lectures during the mid-evening on weekends compared with women who were in favour of early evening sessions (P<0.05). CONCLUSION: It must be borne in mind during the interpretation of the results that the data were collected during the COVID-19 pandemic. It is important to take into consideration the gender, age, cultural background and level of experience while setting up virtual orthodontic learning sessions. Organisers need to tailor their events to meet the needs of the attendees.

Global survey to assess preferences for attending virtual orthodontic learning sessions.

INTRODUCTION: Nowadays, there is a tremendous increase in the conducting of virtual orthodontic learning sessions (VOLSs). This study aimed to investigate the fundamental technical and settings aspects of VOLSs. METHODS: Three thousand orthodontic residents and specialists worldwide were invited via e-mail to complete an anonymous survey, including 23 prevalidated questions. Reminders were sent at 2-week intervals. When the sample size was reached, the survey was locked. Descriptive and inferential statistics were performed. RESULTS: Two hundred ninety-four males and 299 females of various age groups completed the survey; 61.9% of the participants opted to view the speaker's live video and the presentation's screen concurrently. Participants favored a speaker/screen ratio of 1:6 (57.5%), e-housekeeping before VOLSs (58%), appointed moderators for each VOLS (8.31 out of 10; 95% CI: 8.13, 8.48), and a nondistractive virtual background for the speakers/moderators (21.9%). Participants supported broadcasting before the start of the lecture of the VOLS (6.7 out of 10; 95% CI: 6.50, 6.95), with this being significantly influenced by the gender of participants and their continent of residence (P <0.001). Only 17.4% opted against live streaming of the VOLSs. Muting the attendees' microphones (90.5%) and having their videos switched off (62.39%) was preferable; 49.4% used their personal computers to view the lecture, whereas 27.5% used mobile phones. A webinar of 60-90 minutes duration was preferred by 76.6% of the VOLSs participants; 53.1% of the participants opted for a questions and answers session at the end of VOLSs. CONCLUSIONS: Organizers should take into consideration the impact of the digital body language of the speaker, the role of the moderator, cultural background, and privacy concerns of the attendees while organizing VOLSs. Orthodontic clinicians prefer to spend 60-90 minutes attending an interactive online session in which they can raise their questions during and at the end of the VOLSs.

Comparison between two asynchronous teaching methods in an undergraduate dental course: a pilot study.

BACKGROUND: Properly designed and implemented eLearning can lead to improvement of dental teaching quality. Various strategies have been proposed to increase the effectiveness of eLearning in dental education, however, there is a lack of research to assess the effectiveness of these strategies. OBJECTIVE: To investigate dental students' learning performance and perception of a virtual flipped learning format compared to a virtual traditional learning method. METHODS: A crossover pilot study was conducted at the College of Dentistry, Princes Sattam Bin Abdulaziz University, Saudi Arabia. Computer-generated randomization, blinded from researchers who analyzed the results, was performed to allocate 32 participants (aged 23.27 ± 0.86 years) to one of two groups. Participants in the control group were taught through the virtual traditional learning method (VTL) using live video lectures. In contrast, participants in the intervention group were taught through the virtual flipped learning method (VFL) using recorded online lectures and post-lecture virtual discussions. Learning gain and preference were measured by pre- and post-test average score differences and a modified validated survey, respectively. RESULTS: There was no significant difference in learning performance between VFL and VTL groups (P > 0.05). However, students preferred VFL over VTL and the differences were significant among all survey items, except for the opportunity to ask questions. CONCLUSION: Health professions educators are encouraged to carefully design online curricula with efficient learning strategies that help students improve learning performance and foster self-directed learning skills while valuing active learning in an online environment. TRIAL REGISTRATION: NCT04692142 , 31/12/2020.

Effect of mini-implant facilitated micro-osteoperforations on the alignment of mandibular anterior crowding: A randomised controlled clinical trial.

OBJECTIVE: To assess the effects of mini-implant assisted micro-osteoperforations (MI-MOPs) in the alignment of mandibular anterior teeth, and to explore the intervention's associated pain perception (PP) and root resorption (RR) in adults treated by fixed appliance. DESIGN: Multicentre, two-arm and single-blinded randomised clinical trial. SETTING: College of Dentistry, University of Baghdad. PARTICIPANTS: Adolescents (mean age = 18.97 years) undergoing non-extraction orthodontic therapy for the management of mandibular anterior crowding. METHODS: A total of 33 participants (mean age = 18.97 years) undergoing non-extraction orthodontic therapy for the management of moderate mandibular anterior crowding were allocated to the experimental (MI-MOPs, n = 17) or control groups (non-MI-MOPs, n = 16). A series of lower study models were obtained at week 4 (T1), week 8 (T2) and week 12 (T3) in the MI-MOPs group and continued to week 16 (T4) and week 20 (T5) in the non-MI-MOPs group, with all models analysed digitally. Periapical radiographs (PA) were taken before commencing treatment (T0) and T3. Participants were asked to complete a 10-point visual analogue scale (VAS) daily during the first week of treatment. RESULTS: At T0, the mean Little irregularity index (LII) was 5.1 mm (95% confidence interval [CI] = 4.95-5.23) with no statistically significant difference between groups (P = 0.766). At T1, T2 and T3, t-test showed statistically significant differences in the LII (P < 0.05) in favour of the MI-MOPs group; mean differences (MD) were -1.16mm (95% CI = -1.36 to -0.96), -1.77 mm (95% CI = -1.93 to -1.59) and -1.58 mm (95% CI = -1.67 to -1.48), respectively. Mean treatment time from baseline to final alignment was 10.41 weeks (95% CI = 9.92-10.89) in the MI-MOPs group and 16.62 weeks (95% CI = 16.11-17.13) in the non-MI-MOPs groups, which was statistically significant (MD -6.21 mm, 95% CI = -6.88 to -5.53, P < 0.05). Conversely, Mann-Whitney U-test and Wilcoxon signed-rank test showed no significant differences in terms of PP and RR between the groups (P > 0.05). The participants in the MI-MOPs group experienced a higher degree of RR (P < 0.05) secondary to intervention. No other significant adverse events were reported during the trial. CONCLUSION: This trial found that combining MI-MOPs with non-extraction-based fixed orthodontic therapy in adults mildly shortens the duration of the alignment phase. RR should be monitored throughout the treatment when using MI-MOPs (ClinicalTrials.gov NCT04778241).

Do longitudinal orthodontic trials use appropriate statistical analyses? A meta-epidemiological study.

BACKGROUND: In orthodontic trials, longitudinal designs with multiple outcome measurements over time are common. The aim of this epidemiological study was to examine whether optimal statistical analysis approaches have been used in longitudinal orthodontic trials. METHODS: Pubmed was searched in August 2021 for longitudinal orthodontic trials with at least three time points of outcome assessment published in the 2017-20 period. Study selection and data extraction were done independently and in duplicate. The analysis approaches undertaken were tabulated and associations between study characteristics and the use of optimal analysis or not were assessed using Fisher's exact test and logistic regression. RESULTS: One hundred forty-seven out of 563 unique records were deemed eligible for inclusion. Only 26.50% of these trials used an optimal statistical analysis for longitudinal data where the data structure is accounted for. None of the study characteristics except the statistical significance of the results were associated with the appropriateness of the statistical analysis. The odds of significant results in studies with suboptimal analyses were higher than that in studies with optimal longitudinal analyses (odds ratio: 3.48, 95% confidence interval: 1.62, 7.46, P = 0.001). For the studies with optimal analysis, the most frequent test was repeated-measure analysis of variance (RM-ANOVA). The reporting of the statistical analysis section was suboptimal in the majority of the trials. CONCLUSION: Most longitudinal orthodontic trials are not analysed using optimal statistical approaches. Inferences and interpretation of their results are likely to be compromised.

Global survey to assess preferences when attending virtual orthodontic learning sessions: optimising uptake from virtual lectures.

OBJECTIVES: Understanding the issues concerning the conducting of virtual orthodontic learning sessions (VOLSs) is essential. This study aims to identify attendees- and host-related aspects that could optimise learning and uptake from the VOLSs. METHODOLOGY: Fourteen pre-validated questions were anonymously and electronically sent to 3000 orthodontic residents and specialists globally. The survey included demographic questions and questions to gauge attendees' engagement, memorising, and motivation-related factors. Reminders were sent at two-week intervals to non-respondents. The survey was closed when the sample size was met. Descriptive and inferential statistics were performed. RESULTS: 593 orthodontic residents and specialists (294 males and 299 females), primarily junior orthodontists and residents aged between 25 and 35 years of age, completed the survey. Post-VOLS recording was highly requested by the participants (8.84/10, 95% CI 8.67-9.00) with no significant influence of demographics on this trend (p > 0.05). Most of the participants were in favour of short post-VOLSs feedback (6.79/10 95% CI 6.58-6.99) with significant differences (p = 0.048) between participants from different regions of the world. The average number of screenshots taken was 6.1 per lecture. The learners' interests in attending on-line lectures were mainly to learn new clinical orthodontic tips (96.8%). CONCLUSION: Implementing a short feedback survey after VOLSs, the provision of recording, and the provision of certificates of attendance need to be considered.

Three-dimensional nasolabial changes after maxillary advancement osteotomy in class III individuals: a systematic review and meta-analysis.

Background Class III malocclusions with maxillary retrognathia are commonly treated with single jaw Le Fort I maxillary advancement. The three-dimensional (3D) effects of surgery on the nasolabial region varies among the clinical studies. Quantifying these changes is of great importance for surgical planning and obtaining valid consent. Objectives To investigate the 3D relationship between soft tissue and skeletal changes secondary to Le Fort I maxillary advancement surgery in skeletal class III patients.Search methods Comprehensive search of multiple electronic databases supplemented by a manual and grey literature search were undertaken from inception to 9 June 2020.Selection criteria Studies that evaluated the 3D soft tissue changes of patients before and after maxillary advancement surgery alone.Data collection and analysis Study selection, data extraction and risk of bias assessment were performed independently by two reviewers, with disputes resolved by a third reviewer. A quantitative synthesis of the data was pre-planned for pooling similar outcome measures.Results Four studies were included in the final review and meta-analysis, with a total of 105 patients (mean age 16.7 + 33.9 years). The mean maxillary advancement of the included studies was 5.58 mm (95% CI 5.20-5.96). The sagittal effects of surgery on nose tip projection and prominence were insignificant (P >0.05, two studies); however, subnasal projection (MD 1.7 mm, two studies) and upper lip projection (MD 2.90 mm, four studies) increased significantly in a forward direction after surgery (P <0.05). Le Fort I osteotomy widens the upper philtrum width (MD 0.84 mm, two studies) (P <0.05). Inconsistencies among the included studies were identified; therefore, the results should be interpreted with caution.Conclusions There is weak evidence based on quantitative assessments that Le Fort I maxillary advancement significantly affects the nasolabial soft tissue envelope mainly in a sagittal dimension. These changes are concentrated around the central zone of the nasolabial region. Future prospective studies on maxillary advancement osteotomy with a standardised method of assessment, taking into consideration the confounding factors, are required.

The effectiveness of surgical adjunctive procedures in the acceleration of orthodontic tooth movement: A systematic review of systematic reviews and meta-analysis.

OBJECTIVE: To identify and evaluate the body of the evidence regarding the effectiveness of surgical adjunctive procedures (SAPs) in accelerating orthodontic tooth movement (OTM). DATA SOURCES: Unrestricted search of three electronic databases and manual search up to 12 June 2020 were undertaken. DATA SELECTION: All systematic reviews of randomised and non-randomised controlled trials that investigate the effectiveness of the SAPs in accelerating OTM were included. DATA EXTRACTION: Study selection and data extraction were undertaken independently and in duplicate by two reviewers. A random-effects model with a 95% confidence interval (CI) was generated for comparable outcomes. Two reviewers assessed the quality of the included studies using AMSTAR2 and GRADE. RESULTS: Fourteen systematic reviews were included; however, four systematic reviews were assessed quantitatively. Meta-analysis showed that mean difference (MD) of canine retraction rate, for the first month after SAPs, was mild (MD = 0.65 mm/month). Compared to control, micro-osteoperforations (MOPs) statistically but temporally accelerate lower canine retraction and en masse retraction by 0.25 mm/month and 0.31 mm/month, respectively. There was no significant effect (P>0.05) in terms of molar anchorage loss (MAL) between control and MOP groups. Piezocision non-significantly shortens the duration of en masse retraction (4.30 months, P>0.05), but significantly shortens incisors retraction (101.64 days, P<0.001). MAL is mild but significantly less in the piezocision group compared to the control group (MD = 0.53 mm, P=0.03). Low-level evidence showed that SAPs have no significant effect on root resorption or periodontal health; however, piezocision is associated with transient acute inflammation and noticeable scars. CONCLUSION: Low-level evidence concludes that SAPs accelerate OTMs and reduce treatment duration, but the acceleration is minor and transient. The effect on anchorage loss is variable and technique related. Side effects of SAPs are transient, but some might be aesthetically noticeable. A cost-benefit analysis of SAPs should be considered while making the treatment decision.

Are developmentally missing teeth a predictive risk marker of malignant diseases in non-syndromic individuals? A systematic review.

BACKGROUND: Different genes and loci that are associated with non-syndromic developmental tooth agenesis (TA) have the same causation pathway in the development of tumours including breast cancer (BC), epithelial ovarian cancer (EOC), colorectal cancer (CRC) and lung cancer (LC). OBJECTIVES: To assess the link between TA and the development of cancer. SEARCH SOURCES: This registered review included a comprehensive search of electronic databases (Cochrane Central Register of Controlled Trials [CENTRAL], LILACS, Scopus, Web of Science and Medline via Ovid) until 1 April 2020, supplemented by manual, grey literature and reference lists search. There was no restriction in term of date of publication, gender, race or type of hypodontia. DATA SELECTION: The primary outcome was the relationship between TA and cancer. The secondary outcome was to identify the genetic correlation between TA and cancer. DATA EXTRACTION: Study selection, data extraction and risk of bias assessment were performed independently and induplicate by two reviewers, with disputes resolved by a third reviewer. RESULTS: Eight studies with a moderate-high risk of bias were included in the final review, with a total of 5821 participants. Due to the heterogeneity among the included studies, the data were presented narratively. Limited studies reported a high prevalence of EOC (19.2%-20%) and CRC (82%-100%) in individuals with TA (depending on the study) compared to those without TA (3% for EOC and 0% for CRC). While others reported a weak correlation between EOC and CRC and TA (P > 0.05). Weak evidence suggested a strong correlation between breast, cervical uterine and prostate cancers and TA (P < 0.05). CONCLUSIONS: Though low-quality evidence suggests a link between TA and cancer, it was not possible to verify that TA can hold a predictive value as a marker for cancers. Further research is needed to confirm the association. REGISTRATION: PROSPERO (CRD42020139751).

Does Mini Screw Assisted Rapid Palatal Expansion (MARPE) have an influence on airway and breathing in middle-aged children and adolescents? A systematic review.

OBJECTIVE: This systematic review assessed the effects of tooth-borne (TB), tooth-bone-borne (TBB) and bone-borne (BB) micro-implant assisted rapid maxillary expansion (RPE) on airway dimensions and function in young children and adolescents (10- to 17-years-old). MATERIALS AND METHODS: Unrestricted search in 5 electronic databases until June 6th, 2020 was undertaken. This was supplemented with search in 6 additional resources for published, unpublished and ongoing trials up. Randomized (RCT) and non-randomized (Non-RCT) prospective studies that assessed the influence of the mini-screw-assisted rapid palatal expansion (MARPE) approach on airway and breathing in young children and adolescents were included. Two reviewers performed the study selection and data extraction blindly and in duplicate by two authors while disagreements. A random-effects model with a 95% confidence interval (CI), I2 and Chi2 tests were done. ROBINS-I, Cochrane Risk of Bias and GRADE tools were used. Reporting of this review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. RESULTS: Overall, 518 articles were retrieved; only 3 studies (2 RCT and one non-RCT) met the inclusion criteria. Both TB RPE and BB RPE improved on a short-term basis the dimensions of the airway, though the difference was not significant (P>0.05). TBB RPE significantly improved nasal airflow [(Mean difference (MD) 52.7 cm3/s, 95% confidence interval (95% CI) 9.0-96.4), P=0.020)], reduced nasal resistance (MD -0.20Pa/cm3, 95% (-0.38)-(-0.02), P=0.028), and changed respiratory muscle strength variables (P>0.05). No correlation was found between the anatomical dimensions of the airway and the functional airway parameters (P>0.05). CONCLUSIONS: The short-term airway volumetric changes secondary to MARPE were not significant. The influence of MARPE appliances on breathing is still not clear. Registration PROSPERO database (CRD42020183340).

Phone-based audience response system as an adjunct in orthodontic teaching of undergraduate dental students: a cross-over randomised controlled trial.

BACKGROUND: The advent of electronic teaching facilities improves tutor-student communication. This study aims to explore the effectiveness of Phone-Based Audience Response System (PB-ARS), as an adjunctive pedagogy tool to enhance the retention of orthodontic information by dental students; and to explore the students' perception of PB-ARS. METHODS: This cross-over clustered randomised control trial included 34 males who were in the final year of their undergraduate dental training. Participants were allocated to one of two event groups (G1 and G2) using computer-generated randomisation. Both groups simultaneously attended two different traditional lectures (L 1 and L2) a week apart. During L1, PB-ARS was used as an adjunct to conventional presentation to teach G1 participants, (PB-ARS group) while G2's participants acted as a control group (CG), and were taught using a traditional presentation. In the second week (L2), the interventions were crossed-over. Participants from both groups completed pre- and post-lecture multiple-choice questionnaires (MCQ) to assess their short-term retention of information. Their performance in the final MCQ exam (10 weeks following L2) was tracked to assess the long-term retention of the information. Participants also completed post-lecture questionnaires to evaluate their perceptions. RESULTS: Twenty-nine and 31 participants from the CG and PB-ARS group completed this trial, respectively. Although 87.5% of students in the PB-ARS group showed an improvement in their immediate post-lecture scores compared with 79.3% for the CG, it was statistically insignificant (p = 0.465). Similarly, the intervention showed an insignificant effect on the long-term retention of the knowledge (p = 0.560). There was a mildly but favourable attitude of students towards the use of PB-ARS. However, the difference in the overall level of satisfaction between both groups was statistically insignificant (p = 0.183). CONCLUSION: PB-ARS has a minimal and insignificant effect on the short- and long-term retention of orthodontic knowledge by male undergraduate dental students. PB-ARS was the preferred adjunct tool to conventional classroom teaching. Due to the limitations of this trial, a long-term randomised controlled trial with a larger sample size is recommended.

3D effects of a bone-anchored intra-oral protraction in treating class III growing patient: a pilot study.

OBJECTIVES: The aim of this prospective case series study is to assess the three-dimensional (3D) skeletal and soft tissue effects of the alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol in conjunction with a miniscrew-supported class III elastic wear in class III growing patients. MATERIALS AND METHODS: Fourteen consecutive participants (mean age 12.05 ± 1.09 years), who displayed class III malocclusions with retrognathic maxillae, were recruited. A cone beam computed tomography (CBCT) scan was acquired before commencing treatment (T1). All participants were treated with a tooth-bone-borne rapid maxillary expansion (hybrid MARME) appliance that was activated by the Alt-RAMEC protocol for 9 weeks. This was followed by full-time class III elastics, delivering 400 g/side, to protract the maxilla. When a positive overjet was achieved, protraction was ceased and a post-treatment CBCT scan (T2) was taken. The 3D analysis of pre- and post-treatment CBCT scans was blinded. The scans were registered on the anterior cranial base. The Euclidean distance between the two extracted surface models of the pre- and post-treatment scans was displayed as a color surface map. RESULTS: All participants completed the intervention successfully. The majority of the participants showed protraction of the anterior maxillary region (71.4%) and in the zygomatic processes (64.2%). The maxilla significantly protracted (SNA 1.87° ± 1.06°; Vert.T-A 3.29 ± 1.54 mm), while the mandibular base significantly redirected posteriorly (SNB - 2.03° ± 0.85°, Vert.T-B - 3.43 ± 4.47 mm) and that was reflected on the ANB and Wits measurements. No adverse effects were observed. CONCLUSION: Class III elastics combined with the Alt-RAMEC activation protocol of the hybrid MARME appliance is an effective treatment method for mild/moderate class III malocclusions. A long-term follow-up and comparisons with other treatment modalities are required.

The quality of reporting RCT abstracts in four major orthodontics journals for the period 2012-2017.

INTRODUCTION: Clear reporting of the abstracts of randomised controlled trials (RCTs) facilitates the assessment and identification of such trials. AIM: To assess whether authors in the orthodontic field of research currently report RCT abstracts adequately, as defined by the Consolidated Standards of Reporting Trials (CONSORT) statement. DESIGN: An observational retrospective study. METHODS: Electronic searches with supplementary hand searching were undertaken to identify RCTs published in (1) American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), (2) Angle Orthodontist (AO), (3) European Journal of Orthodontics (EJO) and (4) Journal of Orthodontics (JO) for the period from January 2012 to December 2017. The completeness of the abstract reporting was evaluated using a modified CONSORT for abstract statement checklist. RESULTS: A total of 3678 articles were retrieved, but only 224 RCT abstracts were identified and assessed. A high volume of RCTs were published with either the AO (39%) or AJO-DO (32%); the majority of the RCT abstracts (93.6%) were structured. The mean overall abstract reporting quality score was 69.1% (95% confidence interval = 67.5-70.7). In relation to individual quality items, the majority of the RCT abstracts (range = 96-100%) demonstrated clear reporting of the author/contact details, trial design, participants, interventions, objectives, outcomes, number of participants randomised to each group, recruitment, results and conclusions. However, reporting of the title, trial registration, funding and number of analysed participants were only moderately adequate and reporting of the assessment of blinding and adverse events were the least-reported items in the identified abstracts. CONCLUSIONS: As several CONSORT reporting items were poorly reported, it is the responsibility of authors, referees and editors alike to ensure that the CONSORT guidelines are followed.

Correction to: Three-dimensional quantitative assessment of palatal bone height for insertion of orthodontic implants - a retrospective CBCT study.

Following publication of the original article [1], the authors reported that the information regarding ethics approval was accidentally entered under trial registration. A trial registration was not required for this study.

Big toenail and hair samples as biomarkers for fluoride exposure - a pilot study.

BACKGROUND: Biomarkers can aid in detecting and preventing clinical disease through the recognition of change in biological samples. The objective of this case-control study was to further the knowledge on the use of big toenail and hair samples as biomarkers for fluoride exposure. METHODS: A total of 48 participants from an endemic (IC) and a non-endemic (SC) fluorosis region were included. Big toenail and hair samples were collected from each participant and the fluoride concentration was determined. The results of 42 participants were reported: 21 participants (11 males and 10 females, mean age 15.66 + 2.61 years) from IC and 21 participants (11 males and 10 females, mean age 15.06 + 0.79 years) from SC. RESULTS: The mean fluoride concentration of big toenail (2.34 ± 0.26 mg/kg) and hair (0.24 ± 0.04 mg/kg) in the endemic region was significantly higher than the mean fluoride concentration of big toenail (0.98 ± 0.08 mg/kg) and hair (0.14 ± 0.02 mg/kg) in the non-endemic region (p < 0.001 and p = 0.004, respectively). The Receiver Operating Characteristic (ROC) analysis showed that the Area Under the Curve (AUC) value was 0.889 for big toenail (p < 0.001) and 0.762 for hair (p = 0.004) samples. The fluoride assay for big toenails exhibits greater observed accuracy than does the fluoride assay for hair. CONCLUSION: Nail and hair samples can serve as biomarkers to detect biological fluoride exposure according to the data of this pilot study. Nevertheless, hair is less sensitive and specific as a biomarker when AUC values of big toenail and hair samples were compared.

Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review.

BACKGROUND: Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances. Pain experience can vary depending on the appliance, debonding technique, as well as adjunctive measures used. OBJECTIVES: The primary objective of this systematic review was to assess the effectiveness of different debonding techniques and adjunctive methods on pain/discomfort perception during debonding procedure (PDP) of fixed orthodontic appliances. The secondary objective was to assess the effects of anatomic location and gender on PDP of fixed orthodontic appliances. SEARCH METHODS: Multiple electronic databases were searched from inception to August 2018. Reference lists of the included articles were manually screened. SELECTION CRITERIA: Randomized clinical trials (RCTs) and controlled clinical trials were included. DATA COLLECTION AND ANALYSIS: Study selection, data extraction, and risk of bias assessment were performed independently by two reviewers according to Cochrane guidelines, with disputes resolved by a third reviewer. Clinical heterogeneity in study design and methodology prevented quantitative synthesis of the data. RESULTS: The search yielded 198 articles after the removal of duplicates. Seven studies were included in the final review with a total of 307 participants aged 12-60 years. Of the four studies comparing different debonding instruments of labial fixed appliances, two studies showed that the lift-off debonding instrument (LODI) produced lower PDP levels than ligature cutting pliers. Three studies compared adjunctive measures to reduce PDP of labial fixed appliances. Finger pressure and bite wafers significantly reduced PDP levels. Analgesics administration (ibuprofen + paracetamol tablets) 1 hour prior to debonding also reduced PDP. PDP was significantly higher in anterior segments and in females. LIMITATIONS: The authors acknowledge that there was clinical heterogeneity among the included studies and that the potential effect of diurnal variation on pain during debonding was not considered in any of the included trials. CONCLUSIONS AND IMPLICATIONS: There is weak evidence indicating that using the LODI may reduce PDP of labial fixed appliances. Adjunctive measures such as an intrusive force with finger pressure, bite wafers, and preoperative analgesia may further aid PDP control. Further well-designed parallel-group RCTs taking into consideration the diurnal variation in pain are required. REGISTRATION: PROSPERO (CRD42017084474). FUNDING: None. CONFLICT OF INTEREST: The authors declare that there is no conflict of interest.

Three-dimensional quantitative assessment of palatal bone height for insertion of orthodontic implants - a retrospective CBCT study.

BACKGROUND: Orthodontic implants have found widespread use as means of maximum skeletal anchorage in fixed orthodontic treatment, their optimal insertion location in the hard palate, however, is still controversial. The aim of this study was therefore to assess mean bone height across the hard palate and possible age- and sex related differences to identify the most favourable location according to maximum bone height, optimizing primary stability and survival of inserted orthodontic implants. METHODS: In this retrospective cross-sectional study, maxillary pretreatment CBCT scans of 180 healthy orthodontic patients (95♀, 85♂, age 8-40 years) were analysed with regard to vertical palatal bone height in the midpalatal area at 88 validated points distanced 2 mm from each other forming a grid of 0-14 mm posterior to the incisive foramen and 10 mm lateral of the midpalatal suture. Differences in bone height regarding sex and topographical location were assessed by three-way ANOVA. RESULTS: In general, the midpalatal suture as well as the anterior-lateral palatal region showed distinctly higher mean palatal bone height with its maximum 4 mm posterior of the incisive foramen, whereas bone height was limited at the posterior region of the midpalatal suture. Women generally had significantly decreased palatal bone height compared to men at all measurement points. Higher age was associated with a decrease of bone height in the anterior and posterior lateral palatal region and the median palatal raphe with significant age differences. CONCLUSIONS: The midpalatal suture as well as the anterior lateral palate seem to be most suitable for the insertion of orthodontic implants. Palatal bone height, however, was found to be sex- and age-specific, thus sex- and age-related differences should be taken into account, particularly regarding implant length. The ideal insertion site in the palate with sufficient bone height for orthodontic implants is 0-8 mm (men) or 0-6 mm (women) posterior to the incisive foramen and 10 mm lateral to the midpalatal suture. TRIAL REGISTRAION: This study has been registered and approved by the Ethics Committee of the University of Witten/Herdecke, Germany (12/2016).