[Quality of life and 24 hour blood pressure profile in patients with hypertension].

122 patients aged 26 to 70 years (middle ages--54,1 +/- 2,8 years) who had history of arterial hypertension (AH) II stage have been observed. All patients conducted day's monitoring blood pressure (BP) and was determined their quality of life (QL) using the questionnaire of "SF-36 Health Status Survey". The results were conducted in accordance with instruction of the company of "Evidens are Clinico-pharmacological researches". Obtained results are represented in marks using 8 scales, more high mark specifies better QL. All observed patients with II stage hypertension have QL decreased. Decreased degree of night lowering of BP is associated with worsening of psychical status and more expressed limitation of physical activity in patients with hypertension than in those patients with hypertension who have normal day's type of BP.

[Comparative estimation of efficiency and safety of racemic amlodipine and its S-enantiomer in hypertensive patients].

The authors conducted comparative estimation of efficiency and safety of racemic (R+S-) AMLODIPINE and sinistrorotatory isomer--S(-)AMLODIPINE besylate in 63 hypertensive patients from which 32 patients were administered (R+S-) amlodipine and 31--S(-)amlodipine besylate. It was established identity of antihypertensive effect according daily monitoring of blood pressure and monitoring of blood pressure in the office. However, daily dose of S(-)enantiomer was two times less than the dose of (R+S-) amlodipine. Adverse effects (headache, excessive heartbeat, peripheral edema) were less in patients who have received S(-)AMLODIPINE besylate that contributed to more expressed positive clinical dynamic of the state of patients of this group.