Whole and ground sorghum replacing corn on the performance of carcass parts and relative weight of 28-day-old turkey offal / Sorgo integral e moído em substituição ao milho no desempenho, de partes da carcaça e peso relativo de vísceras de perus de 28 dias

The study evaluated the effects of replacing corn with whole and ground sorghum on the zootechnical performance of turkeys fed from one to 28 days of age. A total of 3,960 male Nicholas turkeys were used, divided into six treatments: A) Whole sorghum (100%Sw); B) Ground corn (100%Cg); C) 75% Ground Corn + 25% Ground Sorghum (75%Cg/25%Sg); D) 50% Ground Corn + 50% Ground Sorghum (50%Cg/50%Sg); E) 25% Ground Corn + 75% Ground Sorghum (25%Cg/75%SG) and F) Ground Sorghum (100%Sg). At seven days, live weight was the same between treatments (164 g per bird). At 28 days, the percentage of breast, thigh-drumstick, and wings remained constant in the corn-based diet or partial and total replacements by ground or whole sorghum grain. The length of the small intestine was shorter in treatments B and C. The digestibility of the lipid fraction of the diet (DEE) was significantly higher in the diet with ground sorghum. The treatment based on ground sorghum grain showed the same result for ground corn in the dry matter (DM) and mineral matter (MM DM%) composition of the turkey carcass at 28 days. Ground sorghum influenced the lipid portion of the carcasses (EE DM%). Thus, it is concluded that whole sorghum grain presented the same results as ground sorghum and ground corn for zootechnical performance, carcass muscle mass, and viscera morphometry in turkeys at 28 days of age.

Objetivou-se avaliar os efeitos da substituição do milho pelo sorgo inteiro e moído sobre o desempenho zootécnico de perus fornecido no período de um a 28 dias de idade. Foram utilizados 3.960 perus machos da linhagem Nicholas, divididos em seis tratamentos: A) Sorgo inteiro (100%Si); B) Milho moído (100%M); C) 75% Milho moído + 25% Sorgo moído (75%M25%S); D) 50% Milho moído + 50% Sorgo moído (50%MS); E) 25% Milho moído + 75% Sorgo moído (25%M/75%S) e F) Sorgo moído (100%Sm). Aos sete dias de idade o peso vivo foi igual entre os tratamentos (média de 164 g por ave). Aos 28 dias a percentagem de peito, coxa-sobrecoxa e asas mantiveram-se constantes na dieta a base de milho, ou substituições parciais e totais pelo sorgo grão moído ou inteiro. O comprimento do intestino delgado foi menor no tratamento B e C. A digestibilidade da fração lipídica da ração (DEE) foi significativamente maior na ração com o sorgo moído. O tratamento base sorgo grão moído mostrou o mesmo resultado para milho moído na composição de matéria seca (MS) e de matéria mineral (MM MS) da carcaça dos perus aos 28 dias. O sorgo grão moído influenciou a parcela lipídica das carcaças (EE MS). Desta forma, conclui-se que o grão de sorgo inteiro apresentou os mesmos resultados do que sorgo moído e milho moído para desempenho zootécnico, massa muscular da carcaça e morfometria das vísceras em peruzinhos do alojamento a 28 dias de idade.

Conservative Management of Spondylodiscitis after Laparoscopic Sacral Colpopexy: A Case Report and Review of Literature.

Sacral colpopexy is one of the standard procedures to treat apical pelvic organ prolapse. In most cases, a synthetic mesh is used to facilitate the colposuspension. Spondylodiscitis is a rare but potentially serious complication that must be promptly diagnosed and treated, despite the lack of consensus in the management of this complication. We report one case of spondylodiscitis after a laparoscopic supracervical hysterectomy and sacral colpopexy treated conservatively. We also present a literature review regarding this rare complication. A conservative approach without mesh removal may be possible in selected patients (stable, with no vaginal lesions, mesh exposure or severe neurologic compromise). Hemocultures and culture of image-guided biopsies should be performed to direct antibiotic therapy. Conservative versus surgical treatment should be regularly weighted depending on clinical and analytical progression. A multidisciplinary team is of paramount importance in the follow-up of these patients.

A colpopexia sacral é um dos procedimentos padrão para tratar o prolapso de órgãos pélvicos apical. Na maioria dos casos, uma tela sintética é usada para facilitar a colposuspensão. A espondilodiscite é uma complicação rara, mas potencialmente grave, que deve ser prontamente diagnosticada e tratada, apesar da falta de consenso no manejo dessa complicação. Relatamos um caso de espondilodiscite após histerectomia supracervical laparoscópica e colpopexia sacral tratada conservadoramente. Também apresentamos uma revisão da literatura sobre essa complicação rara. Uma abordagem conservadora sem remoção da tela pode ser possível em pacientes selecionadas (estáveis, sem lesões vaginais, exposição da tela ou comprometimento neurológico grave). Hemoculturas e cultura de biópsias guiadas por imagem devem ser realizadas para direcionar a antibioticoterapia. O tratamento conservador versus o cirúrgico deve ser avaliado regularmente, dependendo da progressão clínica e analítica. Uma equipe multidisciplinar é de suma importância no acompanhamento desses pacientes.

Conservative Management of Spondylodiscitis after Laparoscopic Sacral Colpopexy: A Case Report and Review of Literature / Manejo conservador da espondilodiscite após colpopexia sacral laparoscópica: Relato de caso e revisão da literatura

Abstract Sacral colpopexy is one of the standard procedures to treat apical pelvic organ prolapse. In most cases, a synthetic mesh is used to facilitate the colposuspension. Spondylodiscitis is a rare but potentially serious complication that must be promptly diagnosed and treated, despite the lack of consensus in the management of this complication.We report one case of spondylodiscitis after a laparoscopic supracervical hysterectomy and sacral colpopexy treated conservatively. We also present a literature review regarding this rare complication. A conservative approach without mesh removal may be possible in selected patients (stable, with no vaginal lesions, mesh exposure or severe neurologic compromise). Hemocultures and culture of imageguided biopsies should be performed to direct antibiotic therapy. Conservative versus surgical treatment should be regularly weighted depending on clinical and analytical progression. A multidisciplinary team is of paramount importance in the follow-up of these patients.

Resumo A colpopexia sacral é um dos procedimentos padrão para tratar o prolapso de órgãos pélvicos apical. Na maioria dos casos, uma tela sintética é usada para facilitar a colposuspensão. A espondilodiscite é uma complicação rara, mas potencialmente grave, que deve ser prontamente diagnosticada e tratada, apesar da falta de consenso no manejo dessa complicação. Relatamos um caso de espondilodiscite após histerectomia supracervical laparoscópica e colpopexia sacral tratada conservadoramente. Também apresentamos uma revisão da literatura sobre essa complicação rara. Uma abordagem conservadora sem remoção da tela pode ser possível em pacientes selecionadas (estáveis, sem lesões vaginais, exposição da tela ou comprometimento neurológico grave). Hemoculturas e cultura de biópsias guiadas por imagem devemser realizadas para direcionar a antibioticoterapia. O tratamento conservador versus o cirúrgico deve ser avaliado regularmente, dependendo da progressão clínica e analítica. Uma equipe multidisciplinar é de suma importância no acompanhamento desses pacientes.

Brazilian consensus on the diagnosis and treatment of extremities soft tissue sarcomas.

INTRODUCTION: Soft tissue sarcomas (STSs) are rare tumors and constitute only 1% of all tumors in adults. Indeed, due to their rarity, most cases in Brazil are not treated according to primary international guidelines. METHODS: This consensus addresses the treatment of STSs in the extremities. It was made by workgroups from Brazilian Societies of Surgical Oncology, Orthopaedics, Clinical Oncology, Pathology, Radiology and Diagnostic Imaging, and Radiation Oncology. The workgroups based their arguments on the best level of evidence in the literature and recommendations were made according to diagnosis, staging, and treatment of STSs. A meeting was held with all the invited experts and the topics were presented individually with the definition of the degree of recommendation, based on the levels of evidence in the literature. RESULTS: Risk factors and epidemiology were described as well as the pathological aspects and imaging. All recommendations are described with the degree of recommendation and levels of evidence. CONCLUSION: Recommendations based on the best literature regional aspects were made to guide professionals who treat STS. Separate consensus on specific treatments for retroperitoneal, visceral, trunk, head and neck sarcomas, and gastrointestinal stromal tumor, are not contemplated into this consensus.

Partial breast irradiation: when less could be more.

Breast cancer is the most commonly diagnosed cancer in Brazilian women and the leading causing of cancer death among them. Breast-conserving surgery (BCS) followed by whole breast radiotherapy has become the standard care for early breast cancer. Although the omission of adjuvant breast radiotherapy has been associated with worse oncological outcomes, distance from treatment centers directly affects the employment of adjuvant breast irradiation. In addition to distance, patients from low- and middle-incoming countries suffers from a paucity of radiotherapy centres. It was estimated that 46.6% of the oncological patients requiring radiation therapy for a new primary cancer in 2016 did not received this treatment in the Brazilian public health system. Accelerated partial breast irradiation significantly reduces the treatment time and have the potential to overcome the logistics and social barriers related to adjuvant breast irradiation. During the lasts 30 years, 8 randomized phase III clinical trials showed that partial breast irradiation is a safe, effective, and convenient treatment for selected early breast cancer patients. At AC Camargo Cancer Center experience, for selected patients, partial breast irradiation achieved a 10 years local control of 95.6%. At Angelina Caron Hospital, a regional reference for cancer treatment in the state of Paraná, the median traveled distance from patients home to the radiotherapy department is 24 Km (11-287 Km). The implementation of partial breast irradiation, specially the intraoperative technique, could save patients a median of 1,440 traveled distance.

Parents' perception of dental caries in intellectually disabled children.

The aim of this study was to evaluate the parents' perception of dental caries in children with intellectual disability. This cross-sectional study was conducted with 6 to 14 years old schoolchildren: Group 1 (50 children diagnosed with intellectual disabilities) and Group 2 (50 children without it). The dental caries was assessed by the World Health Organization (WHO) criteria for primary and permanent teeth. Parents' psychosocial perception was assessed by Early Childhood Oral Health Impact Scale (ECOHIS). Similar prevalence of caries free children was found between groups in both dentitions. In primary dentition the caries index was higher in Group 2, and the opposite occurred in permanent teeth. Group 1 presented higher impact (p < .05) in the dimension drinking, eating and pronunciation, whereas in Group 2 there was higher impact (p = .01) on pain, sleep, irritation, the smile and family finances. Findings showed significant impact of dental caries on parents' perception of the oral health related quality of life of children with intellectual disabilities.

Paracoccidioidomicose (doença de Lutz-Splendore-Almeida): manifestações clínicas / Paracoccidioidomycosis disease (Lutz-Splendore-Almeida): clinical manifestations

A paracoccidioidomicose possui clínica polimórfica, com manifestações localizadas em pele e mucosas até comprometimento de vários órgãos e sistemas, potencialmente capaz de provocar sequelas graves e morte. Deve ser incluída no diagnóstico diferencial das doenças granulomatosas, em áreas endêmicas, como ocorre no Brasil, para que seja reconhecida com precocidade, tratada convenientemente e evitada sua evolução para sequelas e morte prematura.

Paracoccidioidomycosis has polymorphic clinical features with lesions located in the skin and mucous membranes, as well as involvement of various organs and systems, as is potentially capable of causing death and serious sequelae. It should be included in the differential diagnosis of granulomatous diseases in endemic areas, including Brazil, so that it is recognized early, for more convenient treatment as to prevent progression with sequelae or premature death.

Paracoccidioidomicose (doença de Lutz-SPLENDORE-almeida): tratamento, duração do tratamento, recidiva, reação paradoxal, prognóstico, profilaxia / Paracoccidioidomycosis (Lutz-Splendore-Almeida disease): treatment, duration of treatment, recurrence, paradoxical reaction, prognosis, prophylaxis

A paracoccidioidomicose, apesar de ser a micose profunda mais importante da América Latina, ainda possui muitas lacunas quanto à sua abordagem, especialmente em relação à duração de seu tratamento, controle de cura e profilaxia. Na dependência da sua gravidade podem ser usadas em seu tratamento: sulfas, azólicos (itraconazol e o cetoconazol)e anfotericina. O prognóstico depende da sua gravidade, do tempo para estabelecer o diagnóstico e da terapêutica instituída. Nas formas leves é bom; e nas formas moderadas e graves, em que há risco do desenvolvimento de sequelas e de morte, é reservado.

Paracoccidioidomycosis, despite being the most important deep mycosis in Latin America, still has many blindspots in terms of its approach, especially in relation to duration of treatment, cure control and prophylaxis. Depending on severity, the following can be used in the treatment: sulfonamides, azoles (itraconazole and ketoconazole), and amphotericin. The prognosis depends on severity, time between onset and diagnosis, and therapy instituted. In mild forms, prognosis is good; in moderate and severe forms, for which there is risk of developing sequelae and death, it is guarded.

Paracoccidioidomicose (doença de Lutz-Splendore-Almeida): propedêutica complementar, diagnóstico diferencial, controle de cura / Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

O diagnóstico da paracoccidioidomicose requer a presença de dados epidemiológicos e de algumas manifestações clínicas mais típicas, entretanto, depende da propedêutica complementar que ainda requer métodos intervencionistas, o diagnóstico diferencial com patologias de grande relevância como tuberculose e linfomas, e o controle de cura.Nesta atualização são discutidos os avanços nessas várias áreas que inclui a propedêutica complementar, o diagnóstico diferencial e o controle de cura, apontando para as perspectivas de desenvolvimento que poderão ajudar a definir melhor a sua abordagem.

The diagnosis of paracoccidioidomycosis requires epidemiological data to be available and for the presence of some more typical clinical manifestations.It requires complementary investigation with interventional methods, differential diagnosis of pathologies of great importance such as tuberculosis and lymphomas, and cure control. This update discussesthe advances in these various areas, which include complementary investigation, differential diagnosis and cure control, pointing to development prospects that may help better define the best approach to this disease.

Colecistite alitiásica aguda: revisão de literatura / Acute acalculous cholecystitis: literature review

A colecistite alitiásica aguda (CAA) trata-se de uma inflamação da vesícula biliar sem a evidência de cálculos biliares. É estimado que ocorra em 2-15% de todos os casos de colecistite aguda e geralmente se associa a condições de saúde críticas, como pós-operatório, trauma recente grave e queimaduras. A etiologia da CAA é multifatorial e sua patofisiologia ainda permanece pouco compreendida. Os principais mecanismos de doença propostos incluem lesão por isquemia-reperfusão, resposta inflamatória sistêmica e estase biliar. O diagnóstico, que costuma ser difícil, é baseado em dados clínicos, laboratoriais, radiológicos e peroperatórios. As manifestações costumam ser inespecíficas, tais como dor em quadrante superior direito, febre, náusea, vômitos, icterícia, leucocitose e função hepática alterada. Os achados de imagem na ultrassonografia (US) e tomografia computadorizada (TC) incluem aumento da espessura da parede e do volume da vesícula biliar, barro biliar, fluido pericolecístico e presença de gás intramural. A combinação de pelo menos três desses achados é necessária para o diagnóstico de CAA. A sensibilidade e especificidade dos métodos de imagem são variáveis, entretanto, considera-se que a TC é superior à US. O tratamento de escolha é colecistectomia, com crescente preferência para utilização da via percutânea. O tratamento clínico associado inclui melhora dos parâmetros hemodinâmicos com drogas vasoativas e medicamentos antimicrobianos. A taxa de mortalidade costuma ser alta (10-67%), independentemente do tratamento instituído. Tal fato é atribuído às condições mórbidas pré-existentes que costumam acompanhar o quadro e contribuem para a rápida progressão da doença para gangrena e perfuração. (AU)

Acalculous cholecystitis (AC) is an acute infiamatory disease of the gallbladder without the evidence of biliary stones. It accounts for 2-15% of all cases of acute cholecystitis and is generally associated with critically ill patients, post-operatory, recente trauma and burns. AC etiology is multifactorial and still obscure. The main mechanisms include ischemia/ reperfusion lesions, systemic infiamatory reaction and biliary stasis. The diagnosis may be difficult, being based on clinical, labaratorial, radiographic and peroperatory features. Clinical manifestations, although inespefics, are right hypochondrial pain, fever, nausea, vomit, jaundice, leukocytosis and high liver enzymes. Ultrasound and tomography aspects are thickening of the gallbladder wall with pericholecystic fluid, biliary sludge and emphysematous cholecystitis. The combination of three or more of those aspects is necessary to confirm the diagnosis of AC. The sensibility and specificity of the radiological exams are insconstant, but the tomography is considered superior to ultrasound. The definitive therapy is cholecystectomy. Associated clinical approach include the use of vasoactive drugs and antibiotics. Mortality is high (10-67%), mainly because of the comobidity diseases. (AU)