RESUMEN
The data presented here are related to the research paper entitled "Norbisabolane and bisabolane sesquiterpenoids from the seeds of Angelica keiskei" [1]. In this data article, we provide 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization mass spectrometry (ESIMS) data of three undescribed norbisabolane- and bisabolene-type sesquiterpenoids, ashitabaol B-D isolated from the seeds of Angelica keiskei.
RESUMEN
A new brominated C(17) acetylenic acid (1) designated as bromotheoynic acid has been isolated from the marine sponge Theonella swinhoei, collected off the coast of Tanegashima, Kagoshima Prefecture, Japan. The structure was determined on the basis of the analysis of its extensive 2D NMR spectroscopic data as well as HRMS. Bromotheoynic acid (1) inhibited maturation of starfish oocytes and cell division of fertilised starfish eggs. Bromotheoynic acid (1) also inhibited proliferation of human leukaemia U937 and HL60 cells, human lung cancer A549 and H1299 cells, and human embryonic kidney 293 (HEK293) cells.
Asunto(s)
Alquinos/análisis , Alquinos/farmacología , Ácidos Grasos Insaturados/análisis , Ácidos Grasos Insaturados/farmacología , Hidrocarburos Bromados/análisis , Hidrocarburos Bromados/farmacología , Theonella/química , Alquinos/aislamiento & purificación , Animales , División Celular/efectos de los fármacos , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Ácidos Grasos Insaturados/aislamiento & purificación , Células HEK293 , Humanos , Hidrocarburos Bromados/aislamiento & purificación , Japón , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Estructura Molecular , Oocitos/efectos de los fármacos , Estrellas de Mar/citología , Estrellas de Mar/efectos de los fármacosRESUMEN
Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC(50) values of 35-100 microM.
Asunto(s)
Citotoxinas/farmacología , Diterpenos/farmacología , Euphorbia/química , Extractos Vegetales/farmacología , Línea Celular , Citotoxinas/química , Diterpenos/aislamiento & purificación , Diterpenos/uso terapéutico , Humanos , Concentración 50 Inhibidora , Estructura Molecular , Componentes Aéreos de las Plantas , Extractos Vegetales/químicaRESUMEN
An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures of 1-3 were determined on the basis of the analysis of their spectroscopic data. Compounds 1-4 exhibited potent superoxide-scavenging activity.
