RESUMEN
This paper presents the synthesis of some tetrazolium salts and metal complexes combinations, which are derived from aromatic and heterocyclic formazans. Elemental quantitative analyses and spectral data confirmed the structure of the new synthesized compounds. The new synthesized compounds were submitted to microbiological tests.
Asunto(s)
Antiinfecciosos/síntesis química , Formazáns/síntesis química , Sales de Tetrazolio/síntesis química , Antibacterianos , Antiinfecciosos/química , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Fenómenos Químicos , Química Física , Formazáns/química , Formazáns/farmacología , Pruebas de Sensibilidad Microbiana/estadística & datos numéricos , Sales de Tetrazolio/química , Sales de Tetrazolio/farmacologíaRESUMEN
The paper presents a synthesis of six new Mannich bases, five hydrazones derived from 1-piperidino-methyl-5-R-isatin and three copper complex compounds of 3-(3'-R-phenyl-pyridazinil-hydrazone)-indoline-2-ones (R=H, CH3, OCH3). The structure of the new compounds was confirmed by the results of the elementary and spectral analysis. Pharmacodynamic studies indicated that copper complex compounds present effective biological properties. Thus, it can be seen that the experimental carrageenan-induced inflammatory oedema was 58.3% inhibited by the complex V (R=CH3) after oral administration. Antimicrobial tests revealed that only compound V (R=OCH3) shows a moderate antimicrobial activity against the gram-positive and gram-negative bacteria, used in the test.
Asunto(s)
Hidrazonas/farmacología , Isatina/análogos & derivados , Bases de Mannich/farmacología , Animales , Antibacterianos , Antiinfecciosos/farmacología , Antiinflamatorios/uso terapéutico , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Carragenina , Evaluación Preclínica de Medicamentos , Hidrazonas/uso terapéutico , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Isatina/farmacología , Isatina/uso terapéutico , Bases de Mannich/uso terapéutico , Ratones , Pruebas de Sensibilidad Microbiana , Relación Estructura-ActividadRESUMEN
This paper presents a synthesis about some hydrazones, formazans and copper's complexes combinations. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR spectral analysis. The antimicrobial and antiinflammatory activities were investigated.