[Changes in the kallikrein-kinin system and lipid peroxidation in patients with diffuse peritonitis, complicated by adult respiratory distress syndrome]. / Izmeneniia kallikrein-kininovoi sistemy i protsessov peroksidatsii lipidov u bol'nykh s razlitym peritonitom, oslozhnennym respiratornym distress-sindromom vzroslykh.

The authors present results of their investigation of the state of kallikrein-kinin system (KKS) and lipid peroxidation (LP) in blood of 22 patients operated upon for acute diffuse peritonitis as a complication of different surgical diseases. In 8 patients who later died the respiratory distress-syndrome of adults (RDSA) developed at the early postoperative period. Activation of KKS and LP were observed in all the patients both in the venous and arterial blood, but it was more intensive in patients with RDSA. In the same group of patients the level of the metabolites under study was higher in the arterial than in the venous blood, which suggests a disturbances of the metabolic function of the lung. The results of the investigation allow a conclusion that antiprotease drugs should be included in the complex treatment of RDSA.

[Energy metabolism in the brain during experimental hemorrhagic shock]. / Sostoianie énergeticheskogo obmena mozga pri éksperimental'nom gemorragicheskom shoke.

State of energy metabolism was studied in brain of rats at agonal steps caused by bleeding during severe and long-term hypotension (30 mmHg, up to 30 hrs). Fast loss of high energy-containing phosphates, cell energy potential of adenine nucleotides and an increase in the lactate/pyruvate ratio were found in non-resistant rats. At the same time, in the most resistant rats normal content of creatine phosphate, ATP was maintained; energy potential was unaltered and anaerobic glycolysis was not activated. Content of glucose and glycogen did not alter considerably in all the animals studied.

[Effectiveness of the elimination of lipid peroxidation products in various methods of detoxication therapy of patients with traumatic shock]. / Effektivnost' éliminatsii produktov perekisnogo okisleniia lipidov pri razlichnykh metodakh detoksikatsionnoi terapii postradavshikh s shokogennoi travmoi.

The shockogenous trauma is followed by a considerable accumulation of lipid peroxidation products in the patient's organism. The most effective of all the measures used for the detoxication was found to be extracorporal use of the donor spleen which resulted in lower content of lipid peroxidation products in blood plasma immediately after the procedure. The maximum effect was observed 1 hour later and persisted during one day after treatment.

[Energy metabolism in skeletal muscles in experimental traumatic shock]. / Energeticheskii obmen v skeletnoi myshtse pri éksperimental'nom travmaticheskom shoke.

Content of ATP and adenylate nucleotides was not markedly altered in rats during a traumatic shock induced by Cannon's procedure involving an impairment of skeletal muscles. Energy potential and content of creatine phosphate were only slightly decreased in these tissues, while the level of lactate and the lactate/pyruvate ratio were increased at the terminal phase.

[The state of energy metabolism in the rat liver after a single acute hemorrhage]. / Sostoianie énergeticheskogo obmena v pecheni krys pri ostroi odnokratnoi krovopotere.

A system of adenine nucleotides and redox state of liver cells as well as activities of dehydrogenases of the tricarbonic acid cycle and of cytochrome oxidase in liver cell homogenates were not altered after an acute single hemorrhage in rats even though the process run into the step of circulation decompensation (AP 40 mm Hg).