[New molecular criteria for assessing the toxic action of hydrazine derivatives. Active forms of oxygen as the key agents in the mechanism of toxicity]. / Novye molekuliarnye kriterii otsenki toksicheskogo deistviia proizvodnykh gidrazina. Aktivnye formy kisloroda kak kliuchevye agenty v mekhanizme toksichnosti.

The data on metabolism of different derivatives of hydrazine are considered. The generalized conception of the toxic effect of the derivatives is suggested. It is accepted that the toxic effect is connected with an elevation of the level of superoxide radicals occurring during oxidative metabolism of hydrazines.

[Effect of hydrazine derivatives, plant growth regulators, on the cytochrome oxidase reaction]. / Vliianie reguliatorov rosta rastenii--proizvodnykh gidrazina na tsitokhromoksidaznuiu reaktsiiu.

Gidrel, digidrel, and sodium salt of maleic hydrazide were shown to exert no influence on oxygen consumption by cytochrome oxidase in concentrations up to 10(-1) M. Similar concentrations of N,N-dimethylamino-succinic acid hydrazide inhibited cytochrome oxidase but did not influence the optical spectrum of cytochrome oxidase.

[Effect of plant growth regulators, hydrazine derivatives, on the state of the microsomal systems of the liver]. / Vliianie reguliatorov rosta rastenii--proizvodnykh gidrazina--na sostoianie mikrosomnykh sistem pecheni.

Hydrazine derivatives (Gidrel, Digidrel and DMMH) at a dose of 1/10 (LD50) inhibit microsomal oxidation, decrease superoxide dismutase activity and activate lipid peroxidation in the rat hepatic microsomes. At the same dose level maleic hydrazide has no effect on the indices studied. The role of superoxide-superoxide dismutase system in the mechanism of microsomal oxidation inhibition by hydrazine derivatives is discussed.