[Incident of CMD in patients with non typical headache]. / Elegchos dysleitourgias tou stomatognathikou systematos se astheneis me dysdiagnosto ponokephalo. (Klinike ereuna se 35 astheneis).

Headache is a very common symptom related to the craniomandibular disorders. In the last 25 years a remarkable number of research studies have proved the close relation between headache and dysfunction of the stomatognathic system. There has been many classifications of the types of headache but none of them has been accepted by the plurality of clinicians and researchers working on the subject. The commonest headache is the one named "tension/headache". Its frequency and its close relation to the craniomandibular disorders have been the reason for the systemic research of this subject with the cooperation of the neurologic clinic of the NIMTS. The material consisted of 35 patients who had headache as a main disturbance. There has been evaluation of their dysfunction as well as their neurologic condition. The results of the study have proved that a considerable number of these patients had headaches due to craniomandibular dysfunction. We also found out that many people suffer from craniomandibular disorders without knowing it. The results of the present research are according with those of similar studies of the international literature.

A preliminary study of brain gliomas with H17E2 monoclonal antibody: immunoscintigraphy and pharmacokinetics.

Ten patients with relapsing high grade brain gliomas and one patient with low grade glioma were studied with a monoclonal antibody (H17E2) against placental alkaline phosphatase. In addition 2 patients with relapsing high grade glioma were studied with a non specific antibody (4D513/2118). 1 mCi of Iodine-131-labelled H17E2 was administered intracarotidly (i.c.) in two, and intravenously (i.v.) in 9 patients. Immunoscintigrams were taken at 0, 2, 24, 48 and 72 hours. Radioactivity was monitored in blood and urine. Tumour/non-tumour ratios were estimated (max. 2.45). All high grade gliomas receiving specific antibody irrespective of the route of administration, gave a positive immunoscintigraphic pattern, increasing in intensity with time. Disappearance of radioactivity in blood was biexpontential with a long component over 30 hours. Urinary excretion of radioactivity ranged from 3.7-21.7% of administered dose/day. The patient with low grade glioma and the patients receiving non specific monoclonal antibody showed a negative pattern, a fast blood clearance and a high urinary excretion. We conclude that a) Iodine-131 labelled H17E2 proved to be stable in vivo and produced satisfactory tumour localisation and b) i.v. route was as good as i.c.

[TMJ dysfunction as first symptom of arteritis temporalis (a case report)]. / E dysleitourgia tou stomatognathikou systematos san proto symptoma tes krotaphikes arteritidas. (Anaphora se mia periptose).

We describe a case of patient 62 year old who suffers from temporal arteritis. It's started atypicalls and because the first symptoms of the disease are often stiffness of the masticatory system and impaired mobility of the lower jaw, the first person to examine the patient may well be a dentist. Other common symptoms are headache, tiredness, slight fever and other general symptoms. Temporal arteritis often raises diagnostic problems, especially with mandibular dysfunction. Correct and early diagnosis is therefore of great importance. The clinical features, electromyographic and histopathological findings and therapy are described and differential diagnostic problems are discussed.

Total and lipid-bound sialic acid in the cerebrospinal fluid of patients with brain tumors.

Total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined in the cerebrospinal fluid (CSF) from 63 patients with various neurological diseases. Of these, 27 had brain tumors: 20 had glioma, and 7 pituitary adenoma. TSA levels were significantly increased in the CSF of 18 of the 20 glioma patients (p less than 0.001), while in the adenoma patients were indistinguishable from the controls; with a 90 and 0% test sensitivity respectively. Conversely, the LSA concentrations were significantly elevated, both, in the glioma and pituitary adenoma patients (p less than 0.001), with a 68 and 100% test sensitivity respectively. These preliminary data suggest that measurement of TSA and LSA in the CSF should prove useful for the diagnosis of brain tumors and, perhaps, in the follow-up of patients undergoing treatment for brain tumors.