RESUMEN
Inflammatory bowel diseases are associated with a state of hypercoagulability secondary to several mechanisms, protein S deficiency being one of these. It can be revealed by spontaneous skin necrosis in children. This condition is rare in adults with Crohn's disease. We are reporting a case of a 35-year-old woman with active Crohn's disease who presented a protein S deficiency responsible for an extensive spontaneous skin necrosis. The evolution was favourable after vascular filling, curative anticoagulation, antibiotic therapy, as well as a high-dose of corticosteroid therapy. We are reporting this case in order to emphasize the importance of considering skin necrosis as a possible cutaneous manifestation of inflammatory bowel diseases.
Asunto(s)
Enfermedad de Crohn/complicaciones , Deficiencia de Proteína S/complicaciones , Enfermedades de la Piel/etiología , Piel/patología , Corticoesteroides/administración & dosificación , Adulto , Antibacterianos/administración & dosificación , Anticoagulantes/administración & dosificación , Enfermedad de Crohn/diagnóstico , Enfermedad de Crohn/tratamiento farmacológico , Femenino , Humanos , Necrosis , Deficiencia de Proteína S/diagnóstico , Deficiencia de Proteína S/tratamiento farmacológico , Piel/efectos de los fármacos , Enfermedades de la Piel/tratamiento farmacológico , Enfermedades de la Piel/patología , Resultado del TratamientoRESUMEN
Meningioma rarely gives rise to metastases outside the brain and meninges. We report here a case of a patient who was treated for anaplastic brain meningioma with surgery and fractionated radiation therapy without any recurrence until 5 years after the operation, when she developed vertebral metastases.
