RESUMEN
PURPOSE: Drug side effects often lead to serious outcomes. Administration of second-generation antipsychotics has resulted in diabetic ketoacidosis and diabetic coma leading to death. Therefore, pharmacists are required to collect information on clinical test values, determine the appropriate test timing, and coordinate with doctors for further clinical laboratory orders, all of which are labor-intensive and time-intensive tasks. In this study, we developed a side effect-monitoring tool and aimed to clarify the influence and efficiency of monitoring side effects by using the tool in patients taking atypical antipsychotics in whom it is necessary to check clinical test values such as blood sugar levels. METHODS: We extracted clinical test values for patients treated with second-generation antipsychotics from electronic medical records. The test values are automatically displayed in the side effect grade classification specified by CTCAE ver. 4.0. A database was constructed using scripts to provide alerts for the timing of clinical testing. The pharmacist used this tool to confirm clinical test values for patients taking medication and requested the physician to inspect orders based on the appropriate test timings. RESULTS: The management tool reduced the pharmacists' effort in collecting information on patients' prescription status and test values. It enabled patients to undergo tests at the appropriate time according to the progression of glucose metabolism and allowed for easy monitoring of side effects. CONCLUSIONS: The results suggested that regardless of pharmacists' experience or skill, the introduction of this tool enables centralization of side effect monitoring and can contribute to proper drug use.
Asunto(s)
Antipsicóticos/efectos adversos , Coma Diabético/epidemiología , Cetoacidosis Diabética/epidemiología , Monitoreo de Drogas/métodos , Farmacéuticos , Anciano , Glucemia/análisis , Glucemia/efectos de los fármacos , Bases de Datos Factuales/estadística & datos numéricos , Coma Diabético/sangre , Coma Diabético/inducido químicamente , Cetoacidosis Diabética/sangre , Cetoacidosis Diabética/inducido químicamente , Hemoglobina Glucada/análisis , Hemoglobina Glucada/efectos de los fármacos , Humanos , Farmacovigilancia , Rol ProfesionalAsunto(s)
Médicos Mujeres , Selección de Profesión , Femenino , Humanos , Japón , Masculino , Sociedades Médicas , Encuestas y CuestionariosAsunto(s)
Grupo de Atención al Paciente , Síndromes de la Apnea del Sueño , Animales , Cardiología , Cardiomiopatías/etiología , Presión de las Vías Aéreas Positiva Contínua , Odontología , Modelos Animales de Enfermedad , Electrocardiografía , Humanos , Medicina Interna , Ratones , Protectores Bucales , Otolaringología , Polisomnografía , Índice de Severidad de la Enfermedad , Síndromes de la Apnea del Sueño/diagnóstico , Síndromes de la Apnea del Sueño/epidemiología , Síndromes de la Apnea del Sueño/fisiopatología , Síndromes de la Apnea del Sueño/terapiaRESUMEN
The possibility that a pairing boson might act as the 'glue' to bind electrons into a Cooper pair in superconductors with a high critical temperature (T(c)) is being actively pursued in condensed-matter physics. Gweon et al. claim that there is a large and unusual oxygen-isotope effect on the electronic structure, indicating that phonons have a special importance in high-temperature superconductors. However, we are unable to detect this unusual oxygen-isotope effect in new data collected under almost identical material and experimental conditions. Our findings point towards a more conventional influence of phonons in these materials.