[Whole-body PET/CT scan with 18F-FDG glucose for a clinical assessment of renal parenchyma viability].

AIM: to perform a comparative analysis of the results of morphofunctional and morphoanatomical studies for the clinical assessment of the viability of the renal parenchyma. MATERIALS AND METHODS: Based on a random sampling method, the results of whole-body PET/CT scan with 18F-FDG glucose in 134 patients with various non-urological disorders were analyzed. However, 13.3% of the participants had concomitant chronic kidney diseases without exacerbation. At the same time, the morphological and anatomical manifestations of chronic kidney disease were studied in 32 patients of the same age and sex in order to evaluate the severity of structural changes in nephron. RESULTS: It was found that among individuals undergone to whole-body PET/CT scan with 18F-FDG glucose for various diseases without a urological history and patients with chronic kidney disease, the parenchyma tropism to energy-intensive labeled glucose molecules had certain differences that correlated with morphoanatomical manifestations of structural changes in the nephron in chronic kidney disease. CONCLUSIONS: The modern morphofunctional PET/CT study of the whole-body viability with 18F-FDG glucose, including the kidneys, is an advanced diagnostic tool that may supplement the results of morphoanatomical studies and monitor the efficiency of treatment.

[Computed tomography and positron emission tomography with 18F-FDG can help in the differential diagnosis of kidney hypoplasia and scarring].

AIM: PET/CT evaluation of the energy metabolism of 18F-FDG in the normal kidney parenchyma, as well as in patients with a newly diagnosed renal hypoplasia or scarring was performed. MATERIALS AND METHODS: Among 30 patients who volunteered to undergo a whole-body PET/CT, in 2 (6.7%) cases an asymptomatic decrease in the kidney size was found. RESULTS: In the framework of this work, an attempt was made to determine a standard approach to visual and mathematical PET/CT assessment of the energy metabolism of 18F-FDG in the normal renal parenchyma and patients with a newly diagnosed renal hypoplasia or scarring. CONCLUSION: The obtained visual and digital data can be used to decide on the feasibility and mapping of a renal biopsy.

Functional and metabolic changes in the brain in neuropathic pain syndrome against the background of chronic epidural electrostimulation of the spinal cord.

Changes in functional and metabolic activities of the brain were evaluated by EEG and positron-emission/computer tomography with 18F-fluorodeoxyglucose in patients with neuropathic pain syndrome previous to and 3 months after implantation of a system for chronic epidural spinal cord stimulation. In most cases, the use of a nerve stimulator was followed by alleviation of neuropathic pain and partial normalization of functional and metabolic activities of brain structures responsible for pain perception, emotiogenic, behavioral, and autonomic responses.