The Yield of Fever, Inflammatory Markers and Ultrasound in the Diagnosis of Acute Cholecystitis: A Validation of the 2013 Tokyo Guidelines.

BACKGROUND: Each year, 1-4 % of people with known gallstones become symptomatic, either presenting with biliary colic or as acute cholecystitis. The distinction between both diagnoses remains challenging. To aid the proper diagnosis, the revised 2013 Tokyo Guidelines (TG 2013) were proposed with a self-acclaimed diagnostic accuracy of over 90 %. However, this accuracy has not been verified by others so far. OBJECTIVE: To determine the accuracy of the TG 2013 guidelines in the diagnosis of acute cholecystitis both in its single components of fever, inflammatory markers and US features and of the combined application of the TG 2013 guidelines as a whole. METHODS: A 5-year retrospective analysis equal to the TG 2013 validation process of all emergency cholecystectomies for acute cholecystitis or persistent biliary pain with an ultrasound performed during the same admission. Acute cholecystitis at histology was the golden standard. RESULTS: Inclusion criteria were met by 169 patients with a prevalence of acute cholecystitis of 52.7 %. The individual features of fever, gallbladder wall thickening and probe tenderness were not significant in univariate analysis. In multivariate analysis only, neutrophil count was an independent predictor. The combined application of the TG 2013 guidelines led to a better sensitivity of 83.1 % at the cost a reduced specificity of 37.5 % compared to neutrophil count alone. The accuracy was therefore only 60.3 %, which was well below the TG 2013 report. CONCLUSION: The 2013 Tokyo Guidelines were slightly better in predicting acute cholecystitis but over diagnosed two-thirds of normal gallbladders compared to neutrophil count alone.

Staging laparoscopy in patients scheduled for pancreaticoduodenectomy minimizes hospitalization in the remaining life time when metastatic carcinoma is found.

OBJECTIVE: To compare the burden of total hospitalization as a ratio of survival of staging laparoscopy versus prophylactic bypass surgery in patients with unresectable periampullary adenocarcinoma. BACKGROUND: Periampullary adenocarcinoma is an aggressive cancer with up to 35% of the patients at surgery found to be unresectable. Palliative prophylactic surgical bypass versus endoscopic stenting has been addressed by randomized controlled trials, but none reported on the burden of hospitalization. METHODS: From a prospective database all patients with periampullary adenocarcinomas with a preoperative patent biliary stent and absent gastric outlet obstruction, but found unresectable during surgery, were analysed. They underwent a staging laparoscopy only versus prophylactic palliative bypass surgery. In-hospital days of the initial admission as well as all consecutive admission days during the remaining life span were compared both in absolute numbers and as relative impact. RESULTS: The inclusion criteria were met by 205 patients. Of these 131 patients underwent a staging laparoscopy detecting metastases in 21 patients. In 184 laparotomies 54 patients underwent prophylactic palliative bypass surgery for unresectable disease. Median total in-hospital-stay in the Laparoscopy Group was 3 days versus 11 days in the Palliative Bypass Group (p = 0.0003). Patients with metastatic disease found during laparoscopy stayed 3.5% of the remaining life time in hospital vs. 10.0% (p = 0.029) in patients with metastatic disease who underwent bypass surgery. CONCLUSIONS: Staging laparoscopy and early discharge in patients with metastatic peri-ampullary carcinoma resulted in reduced hospitalization, both in absolute number of days and as a rate of survival time.

Patients blue on patent blue: an adverse reaction during four sentinel node procedures.

Patent blue V is a well-known dye for visualisation of the lymph nodes in a sentinel lymph node biopsy in breast carcinoma. We present four cases of an adverse reaction to patent blue V, one of which was an anaphylactic shock. The adverse reactions to patent blue and isosulphan blue as found in the literature are discussed and an alternative is suggested.

[Determinants of hospital mortality in surgical patients aged 80 years and over]. / Determinanten van ziekenhuissterfte bij hoogbejaarde chirurgische patiënten.

OBJECTIVE: To determine prognostic factors associated with mortality in patients aged 80 years and over who were treated at the Department of Surgery within a one-year period. DESIGN: Prospective. METHOD: The following items from the complications register were investigated: degree of mobility prior to the operation and the housing circumstances, presence of comorbidity in the case history (heart disease, lung disease, diabetes mellitus, dementia, urgency of admission and operation (elective, urgent, acute)), and the surgical subspecialism (gastroenterology, traumatology, vascular surgery and general surgery). The number of postoperative complications was also examined. Statistical analyses were performed using the chi 2 test and multiple logistic regression analysis. RESULTS: A total of 179 patients were included: 53 men and 126 women, with an average age of 85 years and 86 years respectively. The overall mortality was 11%: 39% in acutely presented patients and 8% in subacute patients. None of the electively operated patients died. The following factors were significantly associated with mortality: subacute presentation (odds ratio 8.5; 95%-CI: 2.8-27), acute presentation (odds ratio 72; 95%-CI: 8-737), cardiological evaluation without further measures was associated with less mortality (odds ratio 0.13; 95%-CI: 0.02-0.85). CONCLUSION: The risk of mortality increased with the urgency of presentation. A cardiological evaluation in which the patient, without the need for further additional measures, was found to be in an optimal condition was associated with a relatively low risk of mortality.