RESUMEN
Young rats were treated by gastric intubation with aluminum lactate (0, 100, and 200 mg Al/kg/day) from postnatal days 5 to 14 to determine the treatment's influence on brain choline acetyltransferase activity and learning abilities. The results indicated that aluminum concentrations in the cerebral areas increased in parallel to plasma aluminum at the dose of 200 mg. In the same case, choline acetyltransferase activity was reduced. At postnatal days 50 and 100, the treated rats did not show alterations in their learning abilities in the 2 tests which are based on different motivations (avoidance of an aversive light or alimentary motivation) and different ways of achievement (pressing on a lever or running in a maze). A low reduction in the general activity, particularly in the radial maze test, was only observed in rats treated with 200 mg Al/kg/day.
Asunto(s)
Animales Recién Nacidos/metabolismo , Colina O-Acetiltransferasa/efectos de los fármacos , Lactatos/farmacología , Aprendizaje/efectos de los fármacos , Animales , Animales Recién Nacidos/psicología , Condicionamiento Operante/efectos de los fármacos , Femenino , Intubación Gastrointestinal , Ácido Láctico , Masculino , Ratas , Ratas Endogámicas , Conducta EspacialRESUMEN
Pregnant rats were treated orally with aluminum lactate (400 mg Al/kg/day) during three periods of gestation to determine the treatment's influence on mortality, weight gain, neuromotor maturation, and learning abilities of their pups. No effect of treatment on litter size, mortality rate, and weight gain of pups was detected. In the negative geotaxis test, the scores of pups from females treated during the second and third weeks of gestation were diminished. In the locomotor coordination and the operant conditioning tests, significant differences in the comparison of controls vs. the three treated groups were found, indicating long-term effects of early intoxication upon the central nervous system.
Asunto(s)
Condicionamiento Operante/efectos de los fármacos , Feto/efectos de los fármacos , Lactatos/envenenamiento , Actividad Motora/efectos de los fármacos , Animales , Condicionamiento Operante/fisiología , Femenino , Ácido Láctico , Tamaño de la Camada/efectos de los fármacos , Intercambio Materno-Fetal , Mortalidad , Embarazo , Ratas , Ratas Endogámicas , Aumento de Peso/efectos de los fármacosRESUMEN
The oral treatment of pregnant rats by aluminum chloride or lactate at various doses was applied from day 1 to day 21 of gestation to determine its influence on mortality, weight evolution, and neuromotor maturation of their pups. No effect of treatment on litter size was detected, but an increased mortality appeared during the first week: treatment by aluminum lactate was less active than was an equivalent treatment by aluminum chloride. Weight was transitorily delayed, but the reversal of this effect could be attributed to the decrease of litter size. The neuromotor maturation of surviving pups treated with the two aluminum salts showed an important impairment during the first 2 weeks of postnatal life.
Asunto(s)
Compuestos de Aluminio , Aluminio/toxicidad , Cloruros/toxicidad , Desarrollo Embrionario y Fetal/efectos de los fármacos , Lactatos/toxicidad , Intercambio Materno-Fetal , Administración Oral , Cloruro de Aluminio , Animales , Peso al Nacer/efectos de los fármacos , Femenino , Muerte Fetal/inducido químicamente , Tamaño de la Camada/efectos de los fármacos , Embarazo , Ratas , Reflejo/efectos de los fármacosAsunto(s)
Lactatos/toxicidad , Neuronas Motoras/fisiología , Sistema Nervioso/crecimiento & desarrollo , Animales , Peso Corporal/efectos de los fármacos , Femenino , Crecimiento/efectos de los fármacos , Ácido Láctico , Neuronas Motoras/efectos de los fármacos , Embarazo , Desempeño Psicomotor/efectos de los fármacos , Ratas , Ratas EndogámicasRESUMEN
The oral treatment of pregnant rats with AlCl3 was realized from 8th day of gestation to parturition to determine its influence on the neuromotor development of the young rats with a bank of assessment tests. As the quality of the maternal care has an influence on young rat development, the maternal behavior had also been quantified with different parameters. The results indicated that aluminum, at the two doses (160 and 200 mg/kg), had no effect on food intake, the weight of females and their maternal behavior. On the other hand, pre-weaning mortality was significantly increased in the treated dams' young. Surviving pups showed a delay in their neuromotor development as well as a weight delay during the first postnatal week. Different explicative hypotheses have been considered.