RESUMEN
To evaluate the health impact of spraying organophosphorus insecticides (OPs), 34 male sprayers in the mango belt of Malihabad, a small town located 27 km from Lucknow in North India was selected. Plasma butyryl cholinesterase (PBChE) and complete blood count were assessed among sprayers after spraying pesticides and the findings obtained were compared with those determined in a reference group (n = 18). The most common symptoms observed were burning sensation in the eyes (8.82%), itching/skin irritation (23.52%) and chest symptoms (32.35%) in the exposed workers. Plasma butyrylcholinesterase (PBChE) was significantly decreased in workers. The results indicated significant decrease in the mean value of hemoglobin, hematocrit and platelets count; however, significantly higher count of leukocytes was also observed in the exposed group (sprayers) compared to that observed in the control group (P < 0.05). Monitoring of PBChE in pesticide sprayers could be useful to predict and prevent health hazards of OPs.
RESUMEN
The study was conducted to assess the magnitude of oxidative stress and lung function abnormalities in 34 male pesticide sprayers on exposure to pesticides in mango plantations. Biochemical studies on blood antioxidant enzymes revealed an unchanged glutathione level and increased level of malondialdehyde (P < 0.001), which indicates that pesticide sprayers may have suffered from oxidative stress. Decreased acetyl-cholinesterase levels (P < 0.001) in sprayers compared to the controls suggest inhibition of cholinesterase activity. The present study shows that pesticide toxicity might lead to oxidative stress and airway narrowing resulting in decreased peak expiratory flow rate.
Asunto(s)
Obstrucción de las Vías Aéreas/fisiopatología , Exposición Profesional/efectos adversos , Estrés Oxidativo , Plaguicidas/envenenamiento , Adolescente , Adulto , Obstrucción de las Vías Aéreas/sangre , Obstrucción de las Vías Aéreas/etiología , Antioxidantes/metabolismo , Colinesterasas/sangre , Estudios Transversales , Glutatión/sangre , Humanos , Masculino , Malondialdehído/sangre , Residuos de Plaguicidas/sangreRESUMEN
59 workers exposed to different chemicals during the manufacture of quinalphos, an organophosphate pesticide (OP) and 17 control subjects were studied. Despite similar blood acetylcholinestarase (AChE) levels in both the exposed and control subjects, a significant number of exposed subjects had altered plantar and ankle reflexes. Higher nervous functions such as memory, learning and vigilance were also found to be affected in these subjects. These findings were attributed to chronic low dose combined exposure to different chemicals used/formed in the manufacture of quinalphos. The study raises the doubt that monitoring of AChE alone among subjects engaged in the manufacture of OP pesticides may not be an adequate safeguard as regards to their health.
Asunto(s)
Insecticidas/efectos adversos , Discapacidades para el Aprendizaje/inducido químicamente , Trastornos de la Memoria/inducido químicamente , Exposición Profesional , Compuestos Organotiofosforados/efectos adversos , Reflejo Anormal , Acetilcolinesterasa/sangre , Adulto , Tobillo , Atención/efectos de los fármacos , Biomarcadores/análisis , Industria Química , Pie , Humanos , Masculino , Sensibilidad y EspecificidadRESUMEN
A cross-sectional survey of 489 male subjects in the age group 15 to 65 years engaged directly or indirectly in mango cultivation along with 208 control subjects was carried out to find their socio-economic, environmental and health conditions. The conditions like high illiteracy rate (49.5%), poverty (PCI less than Rs 100 per month, 52.2%), poor housing (mud houses, 66.7%) unsafe water supply (78.6%) were prevailing in the surveyed population. The high respiratory morbidity may be attributed to high prevalence of smoking and prolonged inhalation of organic dusts during farming operation associated with illiteracy and poor socio-economic status. Gastrointestinal disorders were related to poor hygienic conditions, smoking and consumption of contaminated water. The symptoms pertaining to CNS, skin and eyes were found to be associated with exposure to pesticides.
Asunto(s)
Enfermedades de los Trabajadores Agrícolas/etiología , Salud Ambiental , Frutas , Salud Laboral , Plaguicidas/envenenamiento , Adolescente , Adulto , Anciano , Enfermedades de los Trabajadores Agrícolas/epidemiología , Estudios Transversales , Demografía , Estado de Salud , Humanos , India/epidemiología , Masculino , Persona de Mediana Edad , Prevalencia , Ropa de Protección , Factores SocioeconómicosRESUMEN
Twenty-six farm workers handling about 4 kg of commercial grade hexachlorocyclohexane (HCH)/y for 2-5 y and 21 control subjects were studied for chronic effects in clinical, hematological and cardiac variables. No clinically apparent morbidity was detected, but changes in hemoglobin and electrocardiograms were early effects of HCH exposure.
Asunto(s)
Electrocardiografía/efectos de los fármacos , Hemoglobinas/efectos de los fármacos , Hexaclorociclohexano/efectos adversos , Insecticidas/efectos adversos , Exposición Profesional , Recuento de Células Sanguíneas/efectos de los fármacos , Presión Sanguínea/efectos de los fármacos , Femenino , Hemoglobinas/metabolismo , Hexaclorociclohexano/sangre , Humanos , Insecticidas/sangre , Estilo de Vida , Masculino , Pulso Arterial/efectos de los fármacos , Factores Socioeconómicos , EstereoisomerismoRESUMEN
We examined the serum levels of thyroxine and thyroid stimulating hormone in 103 rural subjects with respect to blood levels of organochlorine pesticide and occupation. We found that 24.3% of study subjects had depleted thyroxine levels in association with significantly lower organochlorine pesticide residues in blood. Sex, nutritional status, thyromegaly, or handling of pesticides in the course of work were not found to be factors contributing to depleted thyroxine levels.
Asunto(s)
Hidrocarburos Clorados , Insecticidas/efectos adversos , Exposición Profesional/efectos adversos , Enfermedades de la Tiroides/inducido químicamente , Glándula Tiroides/efectos de los fármacos , Tirotropina/sangre , Tiroxina/sangre , Adulto , Femenino , Humanos , India , Insecticidas/sangre , Masculino , Salud Rural , Enfermedades de la Tiroides/sangre , Pruebas de Función de la Tiroides , Glándula Tiroides/patologíaRESUMEN
To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status of the national population, as well as compared with their counterparts in the unorganized sectors. Respiratory symptoms and impairment rates were significantly higher in workers exposed to soldering fumes. The high prevalence of congested or inflamed throat was also related to chemical exposure specially among solderers and workers exposed to metal oxides. The ocular symptoms and signs were also related to chemical exposure. Musculoskeletal disorders were related to erratic ergonomic postures.
Asunto(s)
Electrónica , Estado de Salud , Enfermedades Profesionales/epidemiología , Adulto , Femenino , Humanos , India/epidemiología , Masculino , Prevalencia , Fumar , Factores SocioeconómicosAsunto(s)
Insecticidas/farmacocinética , Exposición Profesional , Adulto , Contaminantes Ocupacionales del Aire/análisis , Hexaclorociclohexano/sangre , Hexaclorociclohexano/farmacocinética , Hexaclorociclohexano/orina , Humanos , Insecticidas/sangre , Insecticidas/orina , Masculino , Persona de Mediana Edad , Distribución Tisular , Clima TropicalRESUMEN
Thirty subjects engaged in maintenance and repair of moulds used for producing watermarks on paper were studied, along with 27 control subjects from the same paper mill. The workers were simultaneously exposed to copper, chromium, zinc, xylol, and fumes of sulphuric acid in the course of their work. The study subjects were investigated for clinical, occupational, radiological haematological and psychological details. The aforementioned combined exposure was found to be responsible for a high prevalence of symptoms pertaining to the respiratory system and higher nervous functions. Breathlessness (26.7%), expectoration (10.0%) and emphysema (10.0%) were significantly higher among the exposed subjects. The exposed subjects also showed lowered visuomotor coordination and delayed reaction to light and sound stimuli.
Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Cromo/efectos adversos , Cobre/efectos adversos , Enfermedades del Sistema Nervioso/inducido químicamente , Exposición Profesional/análisis , Papel , Enfermedades Respiratorias/inducido químicamente , Ácidos Sulfúricos/efectos adversos , Xilenos/efectos adversos , Zinc/efectos adversos , Adulto , Contaminantes Ocupacionales del Aire/análisis , Cromo/análisis , Cromo/sangre , Cobre/análisis , Cobre/sangre , Humanos , Masculino , Persona de Mediana Edad , Ácidos Sulfúricos/análisis , Xilenos/análisis , Zinc/análisis , Zinc/sangreRESUMEN
Clinical, haematological and biochemical studies of 34 subjects, occupationally exposed to different types of pesticides, were conducted. The findings have been compared with those observed in 14 control subjects. Inhibition of cholinesterase activity was observed in the exposed group. Serum alkaline phosphatase was also found to be raised. Radiological examination revealed pneumonitic patches in the chest skiagrams of three exposed subjects. Paraesthesia with hyporeflexia was also found in 8.8% of exposed subjects. The findings suggest that exposure to multiple pesticides over many years affects the normal functioning of different organ systems and may produce characteristic clinical effects.
Asunto(s)
Enfermedades de los Trabajadores Agrícolas/etiología , Plaguicidas/envenenamiento , Acetilcolinesterasa/sangre , Adulto , Enfermedades de los Trabajadores Agrícolas/sangre , Enfermedades de los Trabajadores Agrícolas/epidemiología , Fosfatasa Alcalina/sangre , Exposición a Riesgos Ambientales , Humanos , India , Plaguicidas/administración & dosificación , Examen Físico , Intoxicación/epidemiologíaRESUMEN
Ninety-four male pump workers, employed in 41 petrol filling stations in Kanpur (formerly Cawnpore) and Lucknow--both in the Ganges plain of north India--were clinically examined. Headache, redness in eyes, lacrimation and signs like coated and/or furred tongue, throat and/or conjunctival congestion and carious teeth were significantly higher (P less than 0.05) in workers exposed to petrol fumes than in controls, as also was the level of phenol in urine (P less than 0.01). Environmental measurements revealed higher concentrations of benzene, sulphur dioxide and photoionizable dust in the air at petrol stations, and most of the symptoms and signs could be attributed to petrol fumes and other environmental pollution.