RESUMEN
Rates of in vitro resistance to antituberculous drugs were examined for all patients hospitalized with active tuberculosis between January 1969 and December 1972, and between March 1975 and September 1976. During the former period, in 31.5 per cent of patients, tuberculosis was resistant to one or more drugs, and in 12.3 per cent of patients was resistant to 2 or more drugs. During the latter period, 35.5 per cent of patients had tuberculosis that was resistant to one or more drugs, and 19.6 per cent had tuberculosis resistant to 2 or more drugs. Resistance to isoniazid and ethambutol increased significantly, whereas resistance to para-aminosalicytic acid decreased. Age, national origin, and length of residence in the United States were not good predictors for the presence of in vitro resistance.
Asunto(s)
Antituberculosos/farmacología , Farmacorresistencia Microbiana , Mycobacterium tuberculosis/efectos de los fármacos , Tuberculosis/microbiología , Ácido Aminosalicílico/farmacología , California , Etambutol/farmacología , Humanos , Isoniazida/farmacología , México/etnología , Factores de Tiempo , Tuberculosis/tratamiento farmacológicoRESUMEN
The changes that occurred in the histological appearances of iliac crest biopsies after haemodialysis for chronic renal failure in 16 patients are described. In the majority there is loss of bone and an increase in resorptive activity that resembles that seen in "disues" osteoporosis. The amount of osteoid present increases in most of the patients and other defects of calcification also make their appearance during the period of dialysis. None of the changes is peculiar to patients treated in this way. The findings are discussed in the light of hypotheses advanced on the condition of "dialysis bone disease".(AU)