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1.
Viruses ; 13(6)2021 05 27.
Artículo en Inglés | MEDLINE | ID: mdl-34072112

RESUMEN

Hantavirus pulmonary syndrome (HPS) is an often-fatal disease caused by New World hantaviruses, such as Sin Nombre orthohantavirus (SNV). In the US, >800 cases of HPS have been confirmed since it was first discovered in 1993, of which 43 were reported from the state of Montana. The primary cause of HPS in the US is SNV, which is primarily found in the reservoir host Peromyscus maniculatus (deer mouse). The reservoir host covers most of the US, including Montana, where multiple studies found SNV in local deer mouse populations. This study aimed to check the prevalence of SNV in the deer mice at popular recreation sites throughout the Bitterroot Valley in Western Montana as compared to previous studies in western Montana. We found high prevalence (up to 20%) of deer mice positive for SNV RNA in the lungs. We were unable to obtain a SNV tissue culture isolate from the lungs but could passage SNV from lung tissue into naïve deer mice. Our findings demonstrate continuing circulation of SNV in western Montana.


Asunto(s)
Reservorios de Enfermedades/virología , Síndrome Pulmonar por Hantavirus/epidemiología , Peromyscus/virología , Enfermedades de los Roedores/epidemiología , Enfermedades de los Roedores/virología , Animales , Anticuerpos Antivirales/sangre , Pulmón/virología , Montana/epidemiología , ARN Viral/análisis , ARN Viral/genética
2.
Am J Trop Med Hyg ; 101(6): 1272-1275, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31674298

RESUMEN

African multimammate rats, Mastomys natalensis, are widely distributed in sub-Saharan Africa and live in close association with humans. In West Africa, numerous field studies have shown these animals may be naturally infected with the relapsing fever spirochete Borrelia crocidurae, the primary cause of tick-borne relapsing fever in this region of the continent. However, naturally infected individual rats have never been examined over time; therefore, the true host competency of these rats for this spirochete is unknown. Therefore, using animals from an established laboratory colony of M. natalensis, rats were experimentally infected with B. crocidurae and their blood examined to 28 days postinoculation. These animals were highly susceptible to infection and displayed prolonged and cyclic spirochetemias. Our results demonstrate these peridomestic rodents are likely competent hosts for infecting argasid tick vectors and play a primary role in the enzootic cycle for B. crocidurae in West Africa.


Asunto(s)
Borrelia/fisiología , Interacciones Microbiota-Huesped , Murinae/microbiología , Fiebre Recurrente/sangre , África Occidental , Animales , Femenino , Masculino , Fiebre Recurrente/microbiología
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