RESUMEN
Varos tibial é um desvio angular decorrente do fechamento precoce parcial da linha fisária de crescimento do osso, levando a um desalinhamento articular com apoio e sobrecarga anormais, causando, secundariamente, osteoartrite, claudicação, luxação de patela, dor e problemas articulares. Neste relato, uma cadela da raça dachshund foi diagnosticada com tal afecção bilateralmente. Foi observado um desvio de ambos os membros posteriores aos 6 meses de idade. A confirmação da deformidade varo foi feita por meio do exame radiográfico e, posteriormente, foi realizada a tomografia e estereolitografia para o planejamento da cirurgia para correção do desvio angular, utilizando a metodologia de correção para desvio angular, denominada de técnica do centro de rotação da angulação (CORA) fechada, removendo uma cunha do osso para a correção da deformidade. A cirurgia foi bem-sucedida, apresentando bons resultados conformacionais, evoluindo sem complicações.(AU)
Tibial pes varus is an angular deviation resulting from the early partial closure of the physeal line of bone growth, leading to joint misalignment with abnormal support and overload, secondarily causing osteoarthritis, claudication, patellar dislocation, pain, among other joint problems. In this report, a female Dachshund canine was diagnosed with this condition bilaterally in the tibias. It was observed a deviation of both hind limbs at 6 months of age. Confirmation of the varus deformity was made through radiographic examination, and later computed tomography and stereolithography were performed to plan the surgery to correct bilateral angular deviation of the tibia, using the angular deviation technique (CORA) closed, removing a wedge from the bone to correct the deviation angular. The surgery was successful, and the angular deviation was correctly corrected, presenting good results to the animal, without complications.(AU)
Asunto(s)
Animales , Femenino , Pie Zambo/diagnóstico , Fijación Interna de Fracturas/veterinaria , PerrosRESUMEN
PURPOSE:: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. METHODS:: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. RESULTS:: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. CONCLUSION:: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.
Asunto(s)
Pulpa Dental/citología , Enfermedades de los Perros/terapia , Traumatismos de la Médula Espinal/veterinaria , Trasplante de Células Madre/veterinaria , Animales , Enfermedad Crónica , Perros , Humanos , Imagen por Resonancia Magnética , Recuperación de la Función , Traumatismos de la Médula Espinal/terapia , Trasplante de Células Madre/métodos , Resultado del TratamientoRESUMEN
Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.(AU)
Asunto(s)
Humanos , Animales , Trasplante de Células Madre/tendencias , Trasplante de Células Madre , Médula Espinal/anomalías , Heridas y LesionesRESUMEN
Abstract Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.
Asunto(s)
Humanos , Animales , Perros , Traumatismos de la Médula Espinal/veterinaria , Trasplante de Células Madre/veterinaria , Pulpa Dental/citología , Enfermedades de los Perros/terapia , Traumatismos de la Médula Espinal/terapia , Imagen por Resonancia Magnética , Enfermedad Crónica , Resultado del Tratamiento , Recuperación de la Función , Trasplante de Células Madre/métodosRESUMEN
BACKGROUND: Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury. RESULT: All dogs improved locomotor and sensory function when examined 90 days after surgery, and showed increased movement of the hind limbs, and were able to stand upright, as well as to take small steps. Tail tone was observed in seven dogs, pain reflexes and defecation return were observed in five dogs. CONCLUSION: The transplantation of bone marrow stem may be a promising, reliable and safe treatment for chronic spinal cord injury.