RESUMEN
Hematology and serum chemistry measurements were performed on blood specimens from 12 male Dunkin-Hartley hairless guinea pigs Crl:IAF(HA)BR and 10 haired Dunkin-Hartley male guinea pigs Crl:(HA)BR. Significantly higher activities of alanine aminotransferase, aspartate aminotransferase, amylase, and creatine kinase were observed in the hairless guinea pigs as compared to the haired strain. Alkaline phosphatase activity was found to be lower in the hairless guinea pig. The hairless guinea pigs were found to have serum urea concentrations approximately 46% higher than the normal guinea pig strain. The erythrocytic mean cell volume of the hairless strain was found to be smaller, with a greater hemoglobin content. Hairless guinea pigs were found to have approximately 40% fewer leukocytes with a reversed lymphocyte:neutrophil ratio compared to the haired guinea pigs which had much higher lymphocyte counts.
RESUMEN
Osmotic fragility of red blood cells exposed to garlic extract was greatly elevated and the hemoglobin spectrum was changed, giving rise to peaks at 505, 536, 576 and 630 nm instead of peaks at 542 and 572 nm of the native hemoglobin. The factor responsible for these changes was heat stable and undialyzable in its native form. Following its boiling, the substance was lost during dialysis.
