[B Streptococcus and other pathogenic bacteria colonization in hospitals in the Gdansk Metro Area]. / Kolonizacja bakteryjna noworodków ze szczególnym uwzglednieniem paciorkowców grupy B.

A survey of group B Streptococcus and other pathogenic bacteria colonization was carried out on 658 neonates in 8 neonatal wards of hospitals in the Gdansk Metro Area and the district of Gdansk. Out of pathogenic bacteria Haemophilus and enteric bacteria the most frequently were isolated. The percentage of Staphylococcus aureus was relatively low (19.4). The group B Streptococcus frequency in throat was established as 3.8% and ranging from 1.7 to 8.8% in particular wards. In two cases group B streptococcus were not isolated. In probes taken from anus of newborn tested typical enteric flora dominated and E coli and Klebsiella sp were the most frequently encountered. Profile and frequency of bacterial colonization indicated that epidemiological situation in majority of particular wards in similar.

[Evaluation of gonadal hormone function in adolescent girls after antineoplastic therapy]. / Ocena funkcji hormonalnej gonad u dziewczat po przebytym leczeniu przeciwnowotworowym.

In 17 girls after the complex anti-neoplasm therapy we estimated the state of genital organs and the course of menorrhagia cycle together with plasma levels of beta-estradiol, progesterone and prolactin assessed by RIA. We found the secondary lack of menorrhagia together with lowered progesterone and beta-estradiol levels in 3 girls, in whom the abdominal cavity was irradiated. In other 3 girls the transient lack of menorrhagia was stated in the course of chemotherapy.

[Psychophysical examinations of adolescent girls with neoplastic diseases during puberty after multidrug chemotherapy]. / Badania psychofizyczne dziewczat z choroba nowotworowa w okresie pokwitania, po zakonczeniu chemioterapii wielolekowej.

We estimated the psychosomatic development of 25 girls aged 13-19 years after antineoplastic therapy. Normal parameters of physical development were stated in all cases. No injury of central nervous system in all cases was seen. Psychological examination revealed strong suppression reactions and evident anxiety signs in majority of girls.

Evaluation of the efficacy of natural human interferon alpha lozenges on the clinical course of childhood neoplasia and in chronic hepatitis B virus infection in patients who were successfully treated for pediatric malignancies.

The immunostimulating and anti-cancer action of interferons (IFNs) has been known for many years. However, IFNs have not been introduced widely into the schemes of oncological treatment because of serious side effects potentiating untoward effects of chemotherapy. In addition using high doses of IFNs by parental routes the cost of such therapy is prohibitively high. Natural human interferon alpha lozenges produced from lymphoblastoid cell line by the Hayashibara Biochemical Lab. Okayama Japan (nHuIFN-alpha, HBL) is used in small doses delivered on oral mucosa. Thus, it might be expected not to cause severe side effects, and is less expensive. Children given antineoplastic and immunostimulatory treatment for cancer were also given nHuIFN-alpha--HBL lozenges containing 50-200 units of IFN per lozenge. Children treated age varied from 3-14 years. The average time of observation was 188 days. In 6 patients nHuIFN-alpha therapy was introduced at the time of the intensive oncological treatment during break periods. Those children had advanced malignant solid tumors. For the other children the IFN therapy was used after the successfully completed oncological treatment. The reason of using nHuIFN-alpha in this group was a long lasting hepatitis B virus antigenemia. The drug was well tolerated by children from both groups and a positive immunostimulating effect was observed. One prominent effect of the nHuIFN-alpha--HBL in children was a reduction of frequency of infections, improvement of appetite and psychological feeling of well being. It seems to us that IFN oral therapy may improve the tolerance of chemotherapy and radiotherapy.