[Haptenic agranulocytosis: treatment with hemopoietic growth factors].

The authors present their own observation of a patient suffering from drug-induced agranulocytosis, cured with filgastrim-neupogen, a recombinant colony-stimulating human granulocyte factor.

[Functional interaction between the determinant and other foci of epileptiform activity created in the cortex of both cerebral hemispheres]. / Funktsional'nye vzaimodeistviia mezhdu determinantnym i drugimi ochagami épileptiformnoi aktivnosti, sozdannymi v kore oboikh polusharii golovnogo mozga.

It was shown in experiments on cats under nembutal anesthesia that creation of a hyperactive focus with a high excitation level in the orbital or coronary cortex of one hemisphere and of a number of foci in the neocortex of the contralateral hemisphere led to formation of a functional complex working in a unified regimen determined by the hyperactive focus activity. The latter plays the role of a determinant structure. Suppression of the determinant focus with nembutal was followed by a decay of the epileptic complex. Section of the corpus callossum (its rostral part) led to derangement in synch ronization of the work between the determinant and other epileptic activity foci. The results of investigation confirmed the conception on the role of the determinant structure in the nervous system activity.

[Mechanism of formation of epileptic activity complexes in the cerebral cortex under the influence of a determinant focus]. / K mekhanizmu obrazovaniia kompleksov épilepticheskoi aktivnosti v kore golovnogo mozga pod vliianiem determinantnogo ochaga.

It was shown in the experiments on cats anesthetized by nembutal that by forming a hyperactive focus with a high level of excitation in the temporal cortex and a number of foci with a less higher level of the excitation in other parts of neocortex, it is possible to create a functional complex, working in a single routine, determined by the activity of hyperactive focus. The latter plays a role of a determinant structure. The inhibition of the determinant focus results in the disturbance of the epileptic complex. Focus nature has no sufficient importance in the realization of the following interrelations: both the determinant focus and dependent foci may be created by means of strychnin and penicillin, disturbing different forms of the inhibition. The results of our investigations evidence a common conception on the role of determinant structures in the activity of the nervous system.