RESUMEN
BACKGROUND: Some lesions not included in the Banff classification, such as inflammation in the scarred areas and total inflammation, have been described to have prognostic value in the evaluation of graft biopsies. Our aim was to reassess kidney graft biopsies and study the impact of histopathologic lesions, both those graded in the Banff classification and those related to inflammation, on the graft function and evolution. METHODS: We selected 20 biopsies exhibiting chronic pathology without a specific phenotype, and we reevaluated them with the use of a modified Banff score. RESULTS: We found statistically significant association between the presence of total inflammation (P = .048; P = .038), the presence of inflammation in scared area (P = .037; P = .018), and creatinine at the time of renal biopsy and 1 year after the renal biopsy, respectively. CONCLUSIONS: Our results suggest that the presence of both inflammation in the scarred areas and total inflammation are related to renal function at the time of the biopsy and to renal function 1 year after the biopsy.
Asunto(s)
Trasplante de Riñón , Riñón/patología , Trasplantes/patología , Biopsia , Enfermedad Crónica , Cicatriz/patología , Creatinina/metabolismo , Femenino , Rechazo de Injerto/patología , Humanos , Masculino , Persona de Mediana Edad , Nefrectomía/métodos , Nefritis/patología , Nefritis/fisiopatología , Puntuaciones en la Disfunción de Órganos , Pronóstico , Trasplantes/fisiopatologíaRESUMEN
La rigidez de las grandes arterias es una respuesta fisiológica en el ser humano al envejecimiento, pero ésta puede estar acelerada por diversos procesos patológicos, entre ellos la hipertensión arterial, la diabetes mellitus, la insuficiencia renal, etc. En la práctica clínica diaria los parámetros clínicos que se relacionan con un aumento de la rigidez arterial son la hipertensión sistólica y la presión del pulso, pero desde hace una década los avances tecnológicos han posibilitado el desarrollo de técnicas no cruentas para el análisis de la onda del pulso a través de la velocidad y análisis de la misma (índice de aumento [IAx]) y existen fundadas esperanzas de que puedan servir para estudiar mejor el posible efecto enlentecedor sobre la rigidez arterial, así como dilucidar si existen diferencias entre las terapias utilizadas
Stiffness of the large arteries is a physiological response in the human being to aging. However, it may be accelerated due to different diseases, such as arterial hypertension, diabetes mellitus, renal failure, etc. In the daily clinical practice, clinical parameters related with an increase in arterial stiffness are systolic hypertension and pulse pressure. However, since one decade ago, technological advances have made it possible to develop non-invasive techniques for the analysis of the pulse wave through velocity and analysis of the pulse wave (augmentation index [AIx]). Furthermore, there are well-founded hopes that they may serve to better study the possible slowing effect on arterial stiffness and whether there are differences between the therapies used
Asunto(s)
Humanos , Hipertensión/fisiopatología , Pulso Arterial , Arterias/fisiopatología , Envejecimiento , Sístole/fisiología , Diabetes Mellitus/complicacionesRESUMEN
A retrospective study was undertaken to evaluate the results achieved by treatment of renal tumor in 6 patients with solitary kidney. Two were treated conservatively, three were submitted to radical nephrectomy, and one patient underwent heminephrectomy. The mean follow-up was 28 months, the mortality rate was 33%, and metastasis was observed in another 33% of this patient group during follow-up.
