1.
Bioorg Med Chem Lett
; 10(24): 2759-63, 2000 Dec 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11133085
RESUMEN
A library of 80 analogues of the antibacterial compound mureidomycin was prepared using solid-phase chemistry techniques.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Técnicas Químicas Combinatorias , Pruebas de Sensibilidad Microbiana , Nucleósidos/síntesis química , Nucleósidos/química , Nucleósidos/farmacología , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 9(7): 1023-8, 1999 Apr 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10230632
RESUMEN
A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant Staphylococcus aureus (MRSA).
