RESUMEN
The full-length genomic sequence of the HLA-DRB1*13:129 allele was identified in a donor of Gujarati population.
Asunto(s)
Cadenas HLA-DRB1 , Humanos , Cadenas HLA-DRB1/genética , AlelosRESUMEN
The novel HLA-A allele HLA-A*02:01:209 sequence identified in a solid organ recipient.
Asunto(s)
Antígenos HLA , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Antígenos HLA/genética , Análisis de Secuencia de ADN , Alelos , Prueba de Histocompatibilidad , Genómica , Antígenos HLA-A/genéticaRESUMEN
The novel HLA-C allele HLA-C*12:365 identified in an individual from the Gujarati population.
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Humanos , Alelos , IndiaRESUMEN
Autoimmunity eventuates when the immune system attacks self-molecules as a result of the breakdown in immune tolerance. Targeting autoimmune diseases via immunomodulation has become an essential strategy in today's era. A B7 superfamily member immune checkpoint, the V-set domain containing T-cell activation inhibitor-1 (VTCN1), also known as B7-H4, B7S1, and B7x, is involved in negatively regulating T-cell activation. VTCN1 transcript has been reported in various lymphoid and non-lymphoid tissues, but its protein expression is restricted, indicating its translational regulation. Dysregulation of VTCN1 has resulted in the exacerbation of various autoimmune diseases. Moreover, increased soluble form of VTCN1 in the patient's sera positively correlates with the disease progression and severity. The current review summarizes all the reports till date, unfolding the role of VTCN1 in various autoimmune diseases and its therapeutic potential.
Asunto(s)
Enfermedades Autoinmunes , Inhibidor 1 de la Activación de Células T con Dominio V-Set , Humanos , Enfermedades Autoinmunes/terapia , Enfermedades Autoinmunes/metabolismo , Autoinmunidad , Activación de Linfocitos , Linfocitos T , Inhibidor 1 de la Activación de Células T con Dominio V-Set/metabolismoRESUMEN
The extended genomic sequences of HLA-DRB1*14:04:07 and -DRB1*15:53 alleles were identified in the Gujarati individuals.
Asunto(s)
Genómica , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Cadenas HLA-DRB1/genética , Alelos , Prueba de HistocompatibilidadRESUMEN
The full length sequences of the HLA-DRB1*07:03 and HLA-DRB1*12:69 alleles identified in transplant donors.
Asunto(s)
Genómica , Donantes de Tejidos , Alelos , Cadenas HLA-DRB1/genética , Secuenciación de Nucleótidos de Alto Rendimiento , HumanosRESUMEN
The full length sequence of HLA-B*15:01:02 and HLA-C*08:72:01 are reported.