RESUMEN
Insulin action was assessed by measuring insulin-mediated glucose disposal (KI) in 13 non-ketotic diabetic patients both before treatment and after normalization of plasma glucose by diet (5 patients) or sulfonylurea (glipizide) therapy (8 patients). While the KI of the diet-treated group was unchanged by therapy, that of the glipizide-treated group was significantly increased. The data show that chronic glipizide therapy is associated with a potentiation of insulin action, which may account for the major anti-diabetic effect of this drug.
Asunto(s)
Diabetes Mellitus/terapia , Glipizida/uso terapéutico , Insulina/uso terapéutico , Compuestos de Sulfonilurea/uso terapéutico , Adulto , Anciano , Glucemia/metabolismo , Diabetes Mellitus/dietoterapia , Diabetes Mellitus/tratamiento farmacológico , Sinergismo Farmacológico , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Insulin can evoke local and systemic hypersensitivity responses after injection. Many individuals receiving commercial insulin preparations experience local reactions, usually of short duration. A case of severe, persistent insulin-induced skin allergy and the use of therapy, including hyposensitization, to alleviate symptoms are discussed.