[Adsorption of Vi antigen on human erythrocytes]. / Adsorbtsiia Vi-antigena na eritrotsitakh cheloveka.

The accumulation of Vi-antigen in the human body was studied with the use of such characteristic as the specific adsorption capacity of red blood cells. This parameter was shown to depend on the phenotype in the ABO blood group system. In cases of typhoid fever an increase in the adsorption capacity of red blood cells was observed at the acute period of the disease. These changes were particularly manifest in patients belonging to groups O and A. The authors suggest that the adsorption of the antigen on red blood cells has a definite kinetics related to the dynamics of the infectious process.

[Specific antigens of the causative agents and their antibodies in the circulating immune complexes in acute dysentery]. / Spetsificheskie antigeny vozbuditelei i antitela k nim v sostave tsirkuliruiushchikh immunnykh kompleksov pri ostroi dizenterii.

The level of circulating immune complexes has been determined in 53 patients in the dynamics of the disease. For the first time circulating immune complexes have been found to contain Shigella sonnei K-antigen and Shigella flexneri O-antigen, as well as IgA, IgG and IgM to Shigella. Shigella antigens can be detected from the first week of the disease, and their occurrence does not depend on the level of circulating complexes in patients blood serum.

[Antibody avidity indices of the saliva and serum antibodies in salmonellosis patients]. / Izuchenie pokazatelei avidnosti antitel sliuny i syvorotochnykh antitel u bol'nykh sal'monellezami.

The avidity characteristics of salivary and serum antibodies have been determined in 179 salmonellosis patients by means of the indirect hemagglutination inhibition test. These investigation have shown that, in contrast to serum antibodies, no changes occur in the avidity of salivary antibodies in the course of the disease. This is due to the fact that secretory antibodies belong to IgA which have no tendency to ripening. The regularities thus established reflect the role of secretory and serum antibodies in the pathogenesis of Salmonella infections.

[Metabolic transformation affected by specific Salmonella O antigen in the lymphocytes of salmonellosis patients]. / Metabolicheskaia perestroika pod vozdeistviem spetsificheskogo O-antigena sal'monell v limfotsitakh bol'nykh sal'monellezom.

Metabolic transformation in the lymphocytes of salmonellosis patients, manifested by changes in the proportion of nucleic acids due to the stimulating action of Salmonella specific O antigen, was studied by the method of microspectral luminescent analysis. The level of single-helix nucleic acids in lymphocytes was shown to increase 6-8 hours after the stimulating action of specific O antigen, which was manifested by the increase of the alpha parameter from 0.21 to 0.68 in salmonellosis patients. This made it possible to confirm the diagnosis of salmonellosis in 92-95% of cases even at the early period of the disease when serodiagnosis could not yet be made.

[Comparative evaluation of the dynamics of physico-chemically different serum O- and K-antibodies in typhoid and chronic typhoid carriers]. / Sravnitel'naia otsenka dinamiki syvorotochnykh O- i K-antitel razlichnoi fiziko-khimicheskoi prirody u bol'nykh briushnym tifom i khronicheskikh briushnotifoznykh bakterionositelei.

The character of immune response to different S. typhi antigens in typhoid fever and chronic typhoid carriership was studied. The comparative evaluation of the functional activity of different classes of immunoglobulins was carried out by means of the indirect immunofluorescent method. 34 typhoid patients and 34 chronic carriers were examined. The speed of change-over from the production of IgM to that of IgG was found to be linked-with the nature of antigenic stimulation. In the dynamics of typhoid infection the changeover from the production of IgM to that of IgG specific to S. typhi O-antigen was observed. At a later period of typhoid fever the spectrum of O-antibodies was similar in their physico-chemical characteristics to that in chronic carriers. K-antibodies in chronic carriers were represented by highly active IgG.

[Genetic aspects of the effect of Vi antigen deposition in the human body. II. The relationship of ABO system phenotypic classification to erythrocyte sorption capacity]. / Geneticheskie aspekty éffekta deponirovaniia Vi-antigena v organizme cheloveka. Soobshchenie II. Sviaz' fenotipicheskoi prined-lezhnosti po sisteme ABO s sorbtsionnoi sposobnost'iu éritrotsitov.

The ability of erythrocytes to absorb Vi-antigen at optimal (Sopt) and minimal (Smin) sensitizing doses in 52 patients suffering from enteric fever and 61 healthy individuals was studied. Smin has been found to be independent of ABO phenotype of both ill and healthy individuals. At the same time Sopt is considerably reduced in patients having A blood group as compared to healthy individuals. Relationship between antigen binding rigidity with erythrocyte receptors and individual blood groups has been determined.