Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis.

Trimetozine is used to be indicated for the treatment of mental illnesses, particularly anxiety. The present study provides data on the pharmacological profile of trimetozine derivative morpholine (3,5-di-tert-butyl-4-hydroxyphenyl) methanone (LQFM289) which was designed from molecular hybridization of trimetozine lead compound and 2,6-di-tert-butyl-hydroxytoluene to develop new anxiolytic drugs. Here, we conduct molecular dynamics simulations, docking studies, receptor binding assays, and in silico ADMET profiling of LQFM289 before its behavioral and biochemical assessment in mice within the dose range of 5-20 mg/kg. The docking of LQFM289 showed strong interactions with the benzodiazepine binding sites and matched well with receptor binding data. With the ADMET profile of this trimetozine derivative that predicts a high intestinal absorption and permeability to blood-brain barrier without being inhibited by the permeability glycoprotein, the oral administration of LQFM289 10 mg/kg consistently induced anxiolytic-like behavior of the mice exposed to the open field and light-dark box apparatus without eliciting motor incoordination in the wire, rotarod, and chimney tests. A decrease in the wire and rotarod´s fall latency coupled with an increase in the chimney test´s climbing time and a decrease in the number of crossings in the open field apparatus at the dose of 20 mg/kg of this trimetozine derivative suggest sedative or motor coordination impairment at this highest dose. The attenuation of the anxiolytic-like effects of LQFM289 (10 mg/kg) by flumazenil pretreatment implicates the participation of benzodiazepine binding sites. The lowering of corticosterone and tumor necrosis factor alpha (cytokine) in LQFM289-treated mice at a single oral (acute) dose of 10 mg/kg suggests that the anxiolytic-like effect of this compound also involves the recruitment of non-benzodiazepine binding sites/GABAergic molecular machinery.

O papel do enfermeiro no gerenciamento de resíduos de saúde: revisão da literatura / The role of the nurse in health waste management: literature review

Analisar o papel do enfermeiro no gerenciamento de resíduos de saúde, e na elaboração e implantação do PGRSS. Metodologia: Foi realizado um estudo do tipo revisão bibliográfica. Para levantamento dos artigos foi realizado busca online na Biblioteca Virtual de Saúde (BVS), usando os Descritores de saúde (Decs): Gerenciamento de resíduos; Resíduos hospitalares; Enfermagem. Os critérios de inclusão foram textos em português, disponíveis na íntegra e publicados entre os anos de 2007 e 2015. Os resíduos Hospitalares são produzidos por estabelecimentos de assistências na saúde, instituições de ensino e pesquisa. A composição desse lixo é a mais variada e vem assumindo grande importância. A COFEN nº 303 ampara o enfermeiro a assumir o cargo de Responsável Técnico do PGRSS. Foram encontrados 14 artigos, destes oito foram excluídos por fuga ao tema e incluíram-se seis artigos. Conclui-se que o papel do enfermeiro no gerenciamento de resíduos dos serviços de saúde é planejar e implementar um plano de gerenciamento desses resíduos, a partir de bases científicas e técnicas, normativas e legais.

To analyze the role of nurses in health waste management, and in the design and implementation of the PGRSS. Methodology: A bibliographic review was carried out. To search the articles, an online search was performed at the Virtual Health Library (VHL), using health descriptors (Decs): Waste management; Hospital waste; Nursing. The inclusion criteria were Portuguese texts, available in full and published between the years 2007 and 2015. Hospital waste is produced by health care establishments, educational institutions and research. The composition of this garbage is the most varied and has been assuming great importance. COFEN No. 303 supports the nurse to assume the position of Technical Officer of the PGRSS. A total of 14 articles were found, of which eight were excluded due to flight to the theme and six articles were included. It is concluded that the role of nurses in health services waste management is to plan and implement a waste management plan based on scientific and technical, normative and legal bases.