Asunto(s)
Edema Macular/inducido químicamente , Oclusión de la Vena Retiniana/inducido químicamente , Inhibidores de la Angiogénesis , Anticuerpos Monoclonales Humanizados , Bevacizumab , Humanos , Inyecciones Intravítreas , Ranibizumab , Proteínas Recombinantes de Fusión/uso terapéutico , Resultado del Tratamiento , Factor A de Crecimiento Endotelial Vascular/uso terapéutico , Agudeza VisualAsunto(s)
Inhibidores de la Angiogénesis/uso terapéutico , Anticuerpos Monoclonales Humanizados/uso terapéutico , Edema Macular/tratamiento farmacológico , Pautas de la Práctica en Medicina/estadística & datos numéricos , Receptores de Factores de Crecimiento Endotelial Vascular/uso terapéutico , Proteínas Recombinantes de Fusión/uso terapéutico , Oclusión de la Vena Retiniana/tratamiento farmacológico , Femenino , Humanos , MasculinoRESUMEN
OBJECTIVES: To evaluate prospectively the gonioscopic findings and their changes during a 3-year follow-up period in patients with acute central/hemicentral retinal vein occlusions (C/HRVOs). MATERIAL AND METHODS: A comprehensive ophthalmological examination of both eyes including static and dynamic gonioscopy as well as ocular biometric measurements was performed in 57 patients with acute C/HRVOs. The angle configuration and its changes, the axial length of the globe, the anterior chamber depth and the corneal thickness were assessed. RESULTS: 12 C/HRVO patients presented with narrow drainage angles (< or = 20 degrees) and 45 had normal angles (> 20 degrees). Ocular globes with narrow angles had axial length and anterior chamber depth significantly smaller as well as cornea thickness significantly greater than the eyes with normal angles. Out of the 12 patients with narrow angles, 6 cases had primary angle closure suspect (PACS), 5 cases had primary angle closure (PAC) and one case primary angle closure glaucoma (PACG). 3 of the 6 PACS patients progressed to PAC in the 6th, 10th, and 18th months of the follow-up period. From the 8 PAC cases existing during the whole study interval, one case progressed to PACG during the 24th month of the folow-up interval. CONCLUSIONS: In the context of an ocular globe having its size significantly smaller than the normal eye, narrow angle may represent a local risk factor predisposing to C/HRVO. Intermittent episodes of angle closure may contribute by increasing the intraocular pressure to the occurrence of C/HRVO as well to the progression of the gonioscopic configuration from PACS to PAC and from PAC to PACG.