RESUMEN
We describe a case of a 36-year-old woman with no psychiatric or somatic history who was presented to the emergency department with a profound change in mental status, more precisely a catatonic status and auditory hallucinations. Due to the unclear aetiology and suspicion of underlying psychiatric problems, the patient was admitted to the psychiatric ward. After discharge against medical advice, readmission was necessary due to deterioration and sudden onset of myoclonus. On further examination, acute disseminated encephalomyelitis (ADEM) was diagnosed. This case illustrates that ADEM can present itself as an initial psychiatric problem and emphasizes the importance of extensive medical clearance at presentation and continued attention for possible somatic origin, even when the initial clearance turns out to be negative.
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Catatonia , Encefalomielitis Aguda Diseminada , Femenino , Humanos , Adulto , Encefalomielitis Aguda Diseminada/diagnóstico , Servicio de Urgencia en Hospital , HospitalizaciónRESUMEN
INTRODUCTION: OSAHS is associated with an increased risk of cardiovascular disease and stroke. Arterial hypertension is a key risk factor to consider due to its impact on health. METHOD: Cross-sectional study carried out on Spanish public service workers. The nocturnal apnoea risk using the Epworth and STOP-Bang questionnaires and their influence on the mean values of blood pressure are assessed. RESULTS: The detection of OSAHS using the Epworth test and, particularly with the STOP-Bang shows a significant relationship with the mean values of blood pressure, with differences between both questionnaires. CONCLUSION: The Epworth and STOP-Bang questionnaires are useful for the initial detection of OSAHS and a higher prevalence of high blood pressure. Both can be used in screening procedures in occupational health.
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Presión Sanguínea , Hipertensión/etiología , Medicina del Trabajo/métodos , Apnea Obstructiva del Sueño/fisiopatología , Encuestas y Cuestionarios , Adulto , Anciano , Estudios Transversales , Femenino , Empleados de Gobierno/estadística & datos numéricos , Humanos , Hipertensión/epidemiología , Hipertensión/prevención & control , Masculino , Tamizaje Masivo/métodos , Persona de Mediana Edad , Polisomnografía , Prevalencia , Apnea Obstructiva del Sueño/complicaciones , Apnea Obstructiva del Sueño/diagnóstico , Apnea Obstructiva del Sueño/epidemiología , Fumar/epidemiología , Clase Social , España/epidemiología , Adulto JovenRESUMEN
OBJECTIVES: Although many neurologists are reluctant to use natalizumab in MS (multiple sclerosis) given the increased risk for PML (progressive multifocal leukoencephalopathy), trust was regained with the introduction of JCV antibody titres as a potent disease-modifying therapy. Literature shows that in patients with a negative JCV serology, the risk of PML is virtually non-existent. Unfortunately, seroconversion causes concern amongst many neurologists. Furthermore, when patients seroconvert, it is still unclear what the risk is of passing the important threshold of 1.5. MATERIALS & METHODS: JCV serology data of 161 patients were analysed, upon treatment with natalizumab at the University Hospital in Lille, France, between May 2012 and November 2014. RESULTS: Of the 81 patients who tested negative for JCV antibody at baseline, 23 (28.3%) seroconverted but only seven (8.6%) passed the threshold of 1.5. Of the 80 patients testing positive for JCV antibody at baseline, eight had an initial JCV antibody titre of 0.9 or lower of which only one of eight (12.5%) patients passed the threshold of 1.5 in the following 3 years. Eight of 15 (53.3%) patients passed this threshold if the initial serology was higher than 0.9. CONCLUSIONS: JCV-negative patients and JCV-positive patients with antibody levels below or equal to 0.9 both have a low risk of surpassing the 1.5 threshold.
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Anticuerpos Antivirales/sangre , Factores Inmunológicos/efectos adversos , Virus JC/inmunología , Leucoencefalopatía Multifocal Progresiva/sangre , Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico , Natalizumab/efectos adversos , Adulto , Femenino , Estudios de Seguimiento , Humanos , Leucoencefalopatía Multifocal Progresiva/epidemiología , Leucoencefalopatía Multifocal Progresiva/etiología , Esclerosis Múltiple Recurrente-Remitente/complicaciones , Pruebas SerológicasRESUMEN
We report two cases of primary progressive multiple sclerosis (PPMS) included in the INFORMS cohort, experiencing a relapse related to a single MRI gadolinium-enhancing lesion 3 months after fingolimod withdrawal. These two patients share similarities with relapsing-remitting multiple sclerosis cases described in the same situation, suggesting that the initiating process of the active demyelinating plaques is also present in PPMS, even without relapses, but may be triggered as fingolimod is withdrawn. Although the results of the INFORMS study suggest that fingolimod may not slow down the progression, some PPMS patients might still benefit from a disease-modifying treatment.
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Clorhidrato de Fingolimod/efectos adversos , Inmunosupresores/efectos adversos , Esclerosis Múltiple Crónica Progresiva/tratamiento farmacológico , Síndrome de Abstinencia a Sustancias/etiología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Recurrencia , Síndrome de Abstinencia a Sustancias/diagnóstico por imagenRESUMEN
In vitro studies have demonstrated that ß2-adrenergic receptor activation stimulates glycogen degradation in astrocytes, generating lactate as a potential energy source for neurons. Using in vivo microdialysis in mouse cerebellar white matter we demonstrate continuous axonal lactate uptake and glial-axonal metabolic coupling of glutamate/lactate exchange. However, this physiological lactate production was not influenced by activation (clenbuterol) or blocking (ICI 118551) of ß2-adrenergic receptors. In two-photon imaging experiments on ex vivo mouse corpus callosum subjected to aglycemia, ß2-adrenergic activation rescued axons, whereas inhibition of axonal lactate uptake by α-cyano-4-hydroxycinnamic acid (4-CIN) was associated with severe axonal loss. Our results suggest that axonal protective effects of glial ß2-adrenergic receptor activation are not mediated by enhanced lactate production.
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Axones/metabolismo , Ácido Láctico/metabolismo , Neuroglía/metabolismo , Receptores Adrenérgicos beta 2/metabolismo , Estrés Fisiológico/fisiología , Sustancia Blanca/metabolismo , Agonistas de Receptores Adrenérgicos beta 2/farmacología , Antagonistas de Receptores Adrenérgicos beta 2/farmacología , Animales , Fármacos del Sistema Nervioso Central/farmacología , Cerebelo/efectos de los fármacos , Cerebelo/metabolismo , Clenbuterol/farmacología , Cuerpo Calloso/efectos de los fármacos , Cuerpo Calloso/metabolismo , Ácidos Cumáricos/farmacología , Ácido Glutámico/metabolismo , Masculino , Ratones Endogámicos C57BL , Neuroglía/efectos de los fármacos , Propanolaminas/farmacología , Estrés Fisiológico/efectos de los fármacos , Sustancia Blanca/efectos de los fármacosRESUMEN
BACKGROUND: To assess the relationship between performance on the Paced Auditory Serial Addition Test (PASAT) and both cerebral blood flow (CBF) and axonal metabolic integrity in normal appearing white matter (NAWM) of the centrum semiovale in patients with multiple sclerosis (MS). METHODS: Normal appearing white matter of the centrum semiovale was investigated with magnetic resonance (MR) imaging in 28 non-depressed individuals (18 patients with MS and 10 healthy controls). CBF was assessed with pseudo-continuous arterial spin labeling. N-acetylacetate/creatine (NAA/Cr) ratios (a metabolic axonal marker) were measured using (1) H-MR spectroscopy. CBF was also measured in frontoparietal cortices and cerebellar hemispheres. RESULTS: In subjects with MS, we found a positive correlation between performance on the PASAT and CBF to the left centrum semiovale (P = 0.008), but not with the NAA/Cr ratio. There were no correlations between PASAT scores and CBF to the right centrum semiovale, frontoparietal cortices, and cerebellar hemispheres. There was no correlation between PASAT scores and NAA/Cr ratios. CONCLUSIONS: Our preliminary results suggest that performance on the PASAT in subjects with MS correlates with CBF to the left centrum semiovale, which contains left frontoparietal white matter association tracts involved in information processing speed and working memory.
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Circulación Cerebrovascular/fisiología , Esclerosis Múltiple/líquido cefalorraquídeo , Esclerosis Múltiple/fisiopatología , Adulto , Ácido Aspártico/análogos & derivados , Ácido Aspártico/líquido cefalorraquídeo , Estudios de Casos y Controles , Creatina/líquido cefalorraquídeo , Evaluación de la Discapacidad , Femenino , Humanos , Modelos Lineales , Espectroscopía de Resonancia Magnética , Masculino , Persona de Mediana Edad , Estadísticas no Paramétricas , TritioRESUMEN
BACKGROUND: Voxel-based morphometry studies in migraine patients showed significant grey matter volume reduction in regions involved in the control of saccadic eye movements. We hypothesized that these changes would be reflected in dysfunctional saccadic behaviour. METHODS: Saccades were recorded by infrared oculography using three different paradigms (pro-saccade with gap, pro-saccade overlap and anti-saccade with gap). We compared the results for migraine patients (n = 80) with those for controls (n = 87). RESULTS: No significant differences were found between migraine patients with (n = 46) and without (n = 34) aura. Migraine patients showed a saccadic behaviour that differed from controls in three respects. In migraine patients, the latencies in the pro-saccade with gap paradigm were borderline significantly longer. Moreover, in both the pro-saccade with gap and the pro-saccade overlap paradigm we observed a larger intra-individual variation of the latency in migraine patients. However, the biggest difference was that the patients who received migraine prophylactic therapy made significantly more anti-saccade errors in the anti-saccade with gap paradigm, suggesting that inhibitory saccade control is impaired in migraine patients depending on the severity of the migraine. CONCLUSION: We suggest a deficient inhibitory control, reflecting an executive dysfunction in the dorsolateral prefrontal cortex or a dysfunction in the cingulate cortex, is present in migraine patients.
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Trastornos Migrañosos/fisiopatología , Movimientos Sacádicos/fisiología , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
This research examines the role of friendship contingent self-esteem (FCSE), or self-esteem that is dependent on the quality of one's friendships, in predicting depressive symptoms. In Study 1, the authors developed a measure of FCSE. Both FCSE and others' approval correlated with self-esteem and depressive symptoms, but when entered simultaneously in a regression equation, only FCSE significantly predicted self-esteem and depressive symptoms. Study 2 showed that dependency and close friendship competence predicted depressive symptoms only for those high in FCSE. In Study 3, a diary study, FCSE predicted self-esteem instability. Self-esteem instability, in turn, predicted depressive symptoms. Furthermore, a three-way interaction of rumination, FCSE, and the valence of the event predicted momentary self-esteem. Findings are discussed with regard to the importance of considering FCSE when investigating interpersonal risk for depression.
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Depresión/fisiopatología , Amigos/psicología , Autoimagen , Adolescente , Adulto , Femenino , Predicción , Humanos , Masculino , Encuestas y Cuestionarios , Texas , Adulto JovenRESUMEN
We report a patient with episodic ataxia (presumably of type 2) who developed cerebral oedema secondary to a common infection (presumably viral). Cerebral oedema may be a part of the clinical spectrum of familial episodic ataxia and argues for an overlap with hemiplegic migraine. It is suggested to consider a diagnosis of episodic ataxia or familial hemiplegic migraine in catastrophic reactions to apparent trivial trauma or infection.