Synthesis of functionalised aromatic oligamide rods.

A current goal in synthetic chemistry is the design and synthesis of molecules that adopt well defined conformations-so called foldamers. In this manuscript we describe a modular approach for construction of rod shaped para-oligobenzamide molecules. Our approach permits regiospecific incorporation of side chains through a phenolic ether linkage on the scaffold; a feature that partly restricts the conformation of the rod through intramolecular hydrogen-bonding.

Macrocyclic scaffolds derived from p-aminobenzoic acid.

The regiospecific synthesis of C3 macrocyclic scaffolds possessing multiple different functional groups is described.