Gold nanoparticles decorated carbon nitride nanosheets as a coreactant regulate the conversion of the dual-potential electrochemiluminescence of Ru(bpy)32+ for Hg2+ detection.

Gold nanoparticles (AuNPs) decorated carbon nitride nanosheets (Au-g-C3N4 NSs) could work as an excellent on-electrode cathodic coreactant for Ru(bpy)32+. Based on the regulation effect of AuNPs and mercury (Hg2+) for the dual-potential electrochemiluminescence (ECL) of Ru(bpy)32+, a simple, sensitive and selective ECL system was created for the ratiometric sensing of Hg2+.

An ultratrace assay of arsenite based on the synergistic quenching effect of Ru(bpy)32+ and arsenite on the electrochemiluminescence of Au-g-C3N4 nanosheets.

A novel ratiometric electrochemiluminescence (ECL) indicator has been constructed for ultratrace As(iii) detection based on the synergistic quenching of ECL emission of Au-g-C3N4 NSs using As(iii) and Ru(bpy)32+, meanwhile generating a new ECL signal of Ru(bpy)32+ with an increased intensity. Due to the dual quenching effect of As(iii) and Ru(bpy)32+ coupled with the generation of the second ECL signal of Ru(bpy)32+, the sensitivity and selectivity for detecting As(iii) are vastly enhanced.

Aggregation-induced emission of luminol: a novel strategy for fluorescence ratiometric detection of ALP and As(v) with high sensitivity and selectivity.

A novel dual-emission fluorescence ratiometric probe of luminol-Tb-GMP CPNPs for highly sensitive and selective detection of ALP and As(v) has been constructed based on the stimulus responsivity of luminol. The introduction of luminol as a ligand for Tb3+, combined with GMP, leads to a sensor which is more robust, sensitive, and efficient.

A novel nanosensor composed of aptamer bio-dots and gold nanoparticles for determination of thrombin with multiple signals.

Thrombin is a crucial multifunctional enzyme involved in many physiological and pathological processes. Its detection is of great importance. In this work, a novel bio-dots nanosensor for detection of thrombin with colorimetric, fluorometric and light-scattering signals is developed. This nanosensor is composed of thrombin-binding aptamer bio-dots (TBA-dots) and gold nanoparticles (AuNPs), where TBA-dots serve as fluorometric reporter and AuNPs function as multiple roles as colorimetric reporter, light scattering reporter and fluorescence quencher. TBA-dots retain inherent structures of aptamer to specifically interact with thrombin and simultaneously induce the aggregation of AuNPs. The mechanism of the sensing system is based on distance-dependent aggregation of AuNPs and fluorescence resonance energy transfer (FRET). The nanosensor needs no further surface functionalization required for the as-prepared bio-dots and AuNPs, which provides a sensitive method for the selective detection of thrombin with a detection limit as low as 0.59nM. In addition, it provides a brand new perspective for bio-dots and its potential use in bioanalysis.

[Superficial needle therapy and development of acup-moxibustion sciences].

Superficial needle is a new type of needling tools. Superficial needling therapy is adopted mainly monouse superficial needle as treatment tools, with local disease as basic marker and needling the surroundings of the disease, with the needle tip towards the focus, and the needle body inserted along the superficial fascial layer, making a sweeping motion and then it was retained. The superficial needling therapy has wide indications, particularly, rapid and lasting analgesic effect for injury and pain of soft tissue.