RESUMEN
Indoor sources of air pollution, such as from cooking and cleaning, play a key role in indoor gas-phase chemistry. The focus of the impact of these activities on air quality tends to be indoors, with less attention given to the impact on air quality outside buildings. This study uses the INdoor CHEmical Model in Python (INCHEM-Py) and the Advanced Dispersion Modelling System (ADMS) to quantify the impact cooking and cleaning have on indoor and outdoor air quality for an idealised street of houses. INCHEM-Py has been developed to determine the concentrations of 106 indoor volatile organic compounds at the point they leave a building (defined as near-field concentrations). For a simulated 140 m long street with 10 equi-distant houses undertaking cooking and cleaning activities, the maximum downwind concentration of acetaldehyde increases from a background value of 0.1 ppb to 0.9 ppb post-cooking, whilst the maximum downwind chloroform concentrations increase from 1.2 to 6.2 ppt after cleaning. Although emissions to outdoors are higher when cooking and cleaning happen indoors, the contribution of these activities to total UK emissions of volatile organic compounds is low (less than 1%), and comprise about a quarter of those emitted from traffic across the UK. It is important to quantify these emissions, particularly as continued vehicle technology improvements lead to lower direct emissions outdoors, making indoor emissions relatively more important. Understanding how indoor pollution can affect outdoor environments, will allow better mitigation measures to be designed in the future that can take into account all sources of pollution that contribute to human exposure.
Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire Interior , Culinaria , Monitoreo del Ambiente , Compuestos Orgánicos Volátiles , Contaminación del Aire Interior/análisis , Contaminación del Aire Interior/estadística & datos numéricos , Contaminantes Atmosféricos/análisis , Compuestos Orgánicos Volátiles/análisis , Ciudades , Contaminación del Aire/estadística & datos numéricos , Contaminación del Aire/análisisRESUMEN
Influenza A virus (IAV) is the primary causative agent of influenza, colloquially called the flu. Each year, it infects up to a billion people, resulting in hundreds of thousands of human deaths, and causes devastating avian outbreaks with worldwide losses worth billions of dollars. Always present is the possibility that a highly pathogenic novel subtype capable of direct human-to-human transmission will spill over into humans, causing a pandemic as devastating if not more so than the 1918 influenza pandemic. While antiviral drugs for influenza do exist, they target very few aspects of IAV replication and risk becoming obsolete due to antiviral resistance. Antivirals targeting other areas of IAV replication are needed to overcome this resistance and combat the yearly epidemics, which exact a serious toll worldwide. This review aims to summarise the key steps in the IAV replication cycle, along with highlighting areas of research that need more focus.
Asunto(s)
Virus de la Influenza A , Gripe Humana , Humanos , Gripe Humana/epidemiología , Antivirales/farmacología , Replicación ViralRESUMEN
This study examined whether a group of captive dolphins displayed anticipatory behaviors before shows. In general, anticipation occurs when an event is being predicted. Anticipatory behavior is defined by Spruijt et al. as "responses elicited by rewarding stimuli that lead to and facilitate consummatory behavior (Spruijt et al., 2001, Appl Anim Behav Sci 72: 145-171)." Using behavioral recording techniques, the behaviors, breathing rates, space use, and activity levels of all dolphins was recorded both before and after shows. Analysis compared pre- and post-show data in addition to looking at gradual changes in behavior prior to show sessions. Significant changes were found in the behavior and space use prior to sessions with the dolphins decreasing their activity levels, spending more time at the surface and moving towards the starting point of a session before it took place. There was a significant increase in the vigilant behavior before sessions, indicating that the dolphins were becoming more alert towards their trainers and other activities around the pool. This result mirrors previous research with other captive species; as feeding time was approaching, the animals seemed to "wait" and look for the handlers. Any behavioral change that may be regarded as anticipatory behavior was not evidently abnormal or stereotypic in nature, and breathing rates remained stable indicating that the animals do not perceive the shows as stressful or as an aversive experience. Additionally, behavior and level of activity remained stable following the sessions.
Asunto(s)
Anticipación Psicológica , Conducta Animal/fisiología , Delfín Mular/fisiología , Animales , Femenino , Vivienda para Animales , MasculinoRESUMEN
Behaviour represents a reaction to the environment as fish perceive it and is therefore a key element of fish welfare. This review summarises the main findings on how behavioural changes have been used to assess welfare in farmed fish, using both functional and feeling-based approaches. Changes in foraging behaviour, ventilatory activity, aggression, individual and group swimming behaviour, stereotypic and abnormal behaviour have been linked with acute and chronic stressors in aquaculture and can therefore be regarded as likely indicators of poor welfare. On the contrary, measurements of exploratory behaviour, feed anticipatory activity and reward-related operant behaviour are beginning to be considered as indicators of positive emotions and welfare in fish. Despite the lack of scientific agreement about the existence of sentience in fish, the possibility that they are capable of both positive and negative emotions may contribute to the development of new strategies (e.g. environmental enrichment) to promote good welfare. Numerous studies that use behavioural indicators of welfare show that behavioural changes can be interpreted as either good or poor welfare depending on the fish species. It is therefore essential to understand the species-specific biology before drawing any conclusions in relation to welfare. In addition, different individuals within the same species may exhibit divergent coping strategies towards stressors, and what is tolerated by some individuals may be detrimental to others. Therefore, the assessment of welfare in a few individuals may not represent the average welfare of a group and vice versa. This underlines the need to develop on-farm, operational behavioural welfare indicators that can be easily used to assess not only the individual welfare but also the welfare of the whole group (e.g. spatial distribution). With the ongoing development of video technology and image processing, the on-farm surveillance of behaviour may in the near future represent a low-cost, noninvasive tool to assess the welfare of farmed fish.