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1.
Environ Res ; 260: 119630, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-39019137

RESUMEN

Although many studies have discussed the impact of Europe's air quality, very limited research focused on the detailed phenomenology of ambient trace elements (TEs) in PM10 in urban atmosphere. This study compiled long-term (2013-2022) measurements of speciation of ambient urban PM10 from 55 sites of 7 countries (Switzerland, Spain, France, Greece, Italy, Portugal, UK), aiming to elucidate the phenomenology of 20 TEs in PM10 in urban Europe. The monitoring sites comprised urban background (UB, n = 26), traffic (TR, n = 10), industrial (IN, n = 5), suburban background (SUB, n = 7), and rural background (RB, n = 7) types. The sampling campaigns were conducted using standardized protocols to ensure data comparability. In each country, PM10 samples were collected over a fixed period using high-volume air samplers. The analysis encompassed the spatio-temporal distribution of TEs, and relationships between TEs at each site. Results indicated an annual average for the sum of 20 TEs of 90 ± 65 ng/m3, with TR and IN sites exhibiting the highest concentrations (130 ± 66 and 131 ± 80 ng/m3, respectively). Seasonal variability in TEs concentrations, influenced by emission sources and meteorology, revealed significant differences (p < 0.05) across all monitoring sites. Estimation of TE concentrations highlighted distinct ratios between non-carcinogenic and carcinogenic metals, with Zn (40 ± 49 ng/m3), Ti (21 ± 29 ng/m3), and Cu (23 ± 35 ng/m3) dominating non-carcinogenic TEs, while Cr (5 ± 7 ng/m3), and Ni (2 ± 6 ng/m3) were prominent among carcinogenic ones. Correlations between TEs across diverse locations and seasons varied, in agreement with differences in emission sources and meteorological conditions. This study provides valuable insights into TEs in pan-European urban atmosphere, contributing to a comprehensive dataset for future environmental protection policies.

3.
POCUS J ; 9(1): 11-13, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38681150

RESUMEN

The tissue diagnosis and staging of all types of lung cancer is foundational for prognosis and establishing the optimal treatment plan. In order to appropriately stage lung cancer, the highest stage should be established using the 8th edition TNM criteria, where tumor size (T), nodal involvement (N), and metastasis (M) are all taken into account. Establishing a tissue diagnosis may involve the use of CT guided biopsy, navigational bronchoscopy, endobronchial biopsy, EBUS, percutaneous lymph node biopsy and/or excisional biopsy of supraclavicular nodes. It is recommended to proceed with the method that is considered least invasive and provides the highest staging. We present a case of recurrent lung adenocarcinoma diagnosed with real time ultrasound-guided fine needle aspiration of a neck lymph node.

4.
Sci Total Environ ; 905: 167178, 2023 Dec 20.
Artículo en Inglés | MEDLINE | ID: mdl-37730028

RESUMEN

High-altitude mountain areas are sentinel ecosystems for global environmental changes such as anthropogenic pollution. In this study, we report a source apportionment of particulate material with an aerodynamic diameter smaller than 10 µm (PM10) in a high-altitude site in southern Europe (Sierra Nevada Station; SNS (2500 m a.s.l.)) during summer 2021. The emission sources and atmospheric secondary processes that determine the composition of aerosol particles in Sierra Nevada National Park (Spain) are identified from the concentrations of organic carbon (OC), elemental carbon (EC), 12 major inorganic compounds, 18 trace elements and 44 organic molecular tracer compounds in PM10 filter samples collected during day- and nighttime. The multivariate analysis of the joint dataset resolved five main PM10 sources: 1) Saharan dust, 2) advection from the urbanized valley, 3) local combustion, 4) smoke from a fire-event, and 5) aerosol from regional recirculation with high contribution of particles from secondary inorganic and organic aerosol formation processes. PM sources were clearly associated with synoptic meteorological conditions, and day- and nighttime circulation patterns typical of mountainous areas. Although a local pollution source was identified, the contribution of this source to PM10, OC and EC was small. Our results evidence the strong influence of middle- and long-range transport of aerosols, mainly from anthropogenic origin, on the aerosol chemical composition at this remote site.

5.
J Sci Food Agric ; 2023 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-37406186

RESUMEN

BACKGROUND: The consumption of foods such as sweet potato and cassava with high levels of carotenoids is a possible solution to reduce vitamin A deficiency. In this study, we evaluated the kinetics of thermal degradation of carotenoids. The content of carotenoids was quantified by high-performance liquid chromatography, first in fresh material, then in flour and finally in bakery products using mixtures of wheat, sweet potato and cassava. The degree of acceptance of the bakery products by children was also assessed through a sensory acceptance test. RESULTS: The study found that the degradation of carotenoid compounds in sweet potato followed first-order kinetics and fitted the Arrhenius equation with correlations of R2 > 0.9. The retention rates of all-trans-ß-carotene were 77%, 56% and 48% at cooking temperatures of 75, 85 and 95 °C respectively, during a cooking time of 20 min. The concentrations of all-trans-ß-carotene, after baking, for bread, cookies and cake were 15, 19 and 14 µg g-1 db, respectively. In a sensory acceptance test carried out in a school, 47.6% of the boys and 79.2% of the girls rated the cookies made from a mixture of cassava, sweet potato and wheat flour with the indicator I like it a lot. CONCLUSION: The content of carotenoid compounds was reduced by exposure to high temperatures and long cooking times. The combinations of cooking time and temperature which minimized degradation of all-trans-ß-carotene occurred at 75 °C-20 min and 95 °C-10 min. All-trans-ß-carotene retentions for bread, cookies and cake were 25%, 15% and 11% respectively. The mixture of wheat, sweet potato and cassava flour can be considered in the development of cookies with positive contributions of all-trans-ß-carotenes and with a good acceptance by children between 9 and 13 years old. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

6.
Fed Pract ; 38(Suppl 2): S30-S34, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-34177239

RESUMEN

OBJECTIVES: Stereotactic ablative radiotherapy (SABR) has become the standard of care for inoperable early-stage non-small cell lung cancer (NSCLC). Many patients cannot safely undergo a biopsy because of poor pulmonary function and are empirically treated with radiotherapy. This study aimed to evaluate factors associated with radiation toxicity in patients receiving empiric SABR. METHODS: We performed a retrospective review of 69 patients. Patients and tumor characteristics, radiation doses, pulmonary function tests, and toxicity (acute ≤ 90 days and late > 90 days) were analyzed to find associations with overall survival on Kaplan-Meier curves and differences in patient populations with χ2 and Mann-Whitney U tests. RESULTS: Median age was 71 years. Tumors were classified as peripheral in 62 patients (89.9%). After a median follow-up of 18 months, 39 patients (56.5%) were alive with 4 local recurrences (5.7%), 10 regional failures (14.3%), and 15 distant metastases (21.4%). Nineteen of 67 (26.3%) patients had acute toxicity of which 9 had acute grade ≥ 2 toxicity. There were differences in overall survival based on operability status (P = .031) and acute toxicity (P < .001). Pretreatment oxygen dependence (P = .003), central location (P < .001), and new oxygen requirement (P = .02) were significantly associated with acute grade ≥ 2 toxicity. No association was found with performance on pulmonary function tests. CONCLUSION: Empiric SABR in presumed early-stage NSCLC appears to be safe and may increase overall survival. Acute grade ≥ 2 toxicity was significantly associated with pretreatment oxygen dependence, central location, and new oxygen requirement. No association was found with poor pulmonary function.

7.
Curr Res Food Sci ; 4: 279-286, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33997794

RESUMEN

High kernel-zinc maize varieties are available to consumers in several countries in Latin America to contribute to increase the zinc intake of their populations. Minerals, phytic acid and amino acids retention were measured after processing six maize varieties including three high kernel-zinc, one quality protein maize and two conventional maize. Grain for each variety was processed into tortillas, arepas and mazamorra, common maize dishes in the region. To evaluate the effect of processing kernel-zinc maize varieties on zinc retention, varieties were grouped in zinc biofortified maize (ZBM) and non-ZBM. Iron, zinc, phytic acid, tryptophan and lysine concentrations in non-processed maize were 17.1-19.1 â€‹µg/g DW, 23.9-33.0 â€‹µg/g DW, 9.9-10.0 â€‹mg/g DW, 0.06-0.08% and 0.27-0.37%, respectively. In tortillas, the iron, zinc, phytic acid and lysine content did not change (p â€‹< â€‹0.05) compared to raw grain, while tryptophan decreased by 32%. True retention of iron in arepas and mazamorra was 43.9 and 60.0%, for zinc 36.8 and 41.3%, and for phytic acid 19.3 and 25.1%. Tortillas had higher zinc retention than arepas and mazamorra due to use of whole grain in the nixtamalization process. Therefore, to contribute to higher zinc intake, nixtamalized tortilla prepared with biofortified zinc maize is recommended. Additionally, promotion of whole grain flour to prepare arepas should be explored to enhance the intake of minerals that are usually confined to aleurone layers and germ.

8.
Rev Esp Cardiol (Engl Ed) ; 74(5): 438-448, 2021 May.
Artículo en Inglés, Español | MEDLINE | ID: mdl-33712348

RESUMEN

Both cancer treatment and survival have significantly improved, but these advances have highlighted the deleterious effects of vascular complications associated with anticancer therapy. This consensus document aims to provide a coordinated, multidisciplinary and practical approach to the stratification, monitoring and treatment of cardiovascular risk in cancer patients. The document is promoted by the Working Group on Cardio Oncology of the Spanish Society of Cardiology (SEC) and was drafted in collaboration with experts from distinct areas of expertise of the SEC and the Spanish Society of Hematology and Hemotherapy (SEHH), the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Radiation Oncology (SEOR), the Spanish Society of General and Family Physicians (SEMG), the Spanish Association of Specialists in Occupational Medicine (AEEMT), the Spanish Association of Cardiovascular Nursing (AEEC), the Spanish Heart Foundation (FEC), and the Spanish Cancer Association (AECC).


Asunto(s)
Cardiología , Enfermedades Cardiovasculares , Hematología , Neoplasias , Oncología por Radiación , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , Enfermedades Cardiovasculares/terapia , Consenso , Factores de Riesgo de Enfermedad Cardiaca , Humanos , Oncología Médica , Neoplasias/complicaciones , Neoplasias/epidemiología , Neoplasias/terapia , Factores de Riesgo
10.
Sci Total Environ ; 762: 143100, 2021 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-33121775

RESUMEN

Understanding the activation properties of aerosol particles as cloud condensation nuclei (CCN) is important for the climate and hydrological cycle, but their properties are not fully understood. In this study, the CCN activation properties of aerosols are investigated at two different sites in southern Spain: an urban background station in Granada and a high altitude mountain station in the Sierra Nevada National Park, with a horizontal separation of 21 km and vertical separation of 1820 m. CCN activity at the urban environment is driven by primary sources, mainly road traffic. Maximum CCN concentrations occurred during traffic rush hours, although this is also when the activation fraction is lowest. This is due to the characteristics of the rush hour aerosol consisting of ultrafine and less hygroscopic particles. In contrast, the mountain site exhibited larger and more hygroscopic particles, with CCN activity driven by the joint effect of new particle formation (NPF) and vertical transport of anthropogenic particles from Granada urban area by orographic buoyant upward flow. This led to the maximum concentrations of CCN and aerosol particles occurring at midday at the mountain site. Clear differences in the diurnal evolution of CCN between NPF events and non-event days were observed at the Sierra Nevada station, demonstrating the large contribution of NPF to CCN concentrations, especially at high supersaturations. The isolated contribution of NPF to CCN concentration has been estimated to be 175% higher at SS = 0.5% relative to what it would be without NPF. We conclude that NPF could be the major source of CCN at this mountain site. Finally, two empirical models were used to parameterize CCN concentration in terms of aerosol optical or physical parameters. The models can explain measurements satisfactorily at the urban station. At the mountain site both models cannot reproduce satisfactorily the observations at low SS.

11.
PLoS One ; 15(11): e0242202, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33175890

RESUMEN

Zinc deficiency is a major public health problem in vulnerable populations of Latin America and the Caribbean. Biofortification of rice (Oryza sativa L.) with zinc has the potential to alleviate zinc deficiencies. However, as plant breeding processes can alter grain culinary quality and favorable sensory attributes, grain quality and consumer acceptability need to be assessed prior to releasing a variety to the public. A grain quality characterization and a sensory acceptability analysis were carried out with two varieties of zinc biofortified rice and a local control both in Bolivia and Colombia. The aim of this study was to evaluate the physicochemical parameters that are significant in consumer acceptance and to determine the acceptability of zinc biofortified rice by consumers. Results of physicochemical parameters were analyzed using ANOVA. The sensory acceptability was evaluated in 243 adults utilizing a 7-point hedonic scale and a Wilcoxon's signed rank test was used to determine the overall acceptability of the varieties. Biofortified rice variety T2-11 and MAC-18 -control 1- were equally accepted by consumers in Bolivia with no significant differences (p<0.05). The grain quality analysis reported that both presented long and slender rice grains (L>7.5 mm and L/B>3), an intermediate to high amylose content (>25%) and a similar level of chalkiness. In Colombia, the biofortified variety 035 presented a higher score in overall acceptance in comparison to biofortified variety 021 and the local variety CICA4 -control 2-. However, no significant differences were observed (p<0.05). Conversely to the other two varieties, the biofortified variety 035 presented the largest size grain (L/B = 2.97), a lower chalkiness and an amylose content above 25%. This study shows that the grain quality properties of rice have an influence on acceptability and that zinc biofortified rice varieties are accepted by consumers.


Asunto(s)
Biofortificación , Comportamiento del Consumidor , Grano Comestible/normas , Oryza/química , Percepción del Gusto , Zinc/análisis , Adolescente , Adulto , Actitud , Bolivia , Colombia , Grano Comestible/química , Femenino , Alimentos Fortificados/normas , Humanos , Masculino , Persona de Mediana Edad
12.
Sci Total Environ ; 744: 140745, 2020 Nov 20.
Artículo en Inglés | MEDLINE | ID: mdl-32727660

RESUMEN

This article presents the results of atmospheric deposition from a 15-sites network which cover remote, agricultural, urban and industrial areas in the Iberian Peninsula and the Balearic Islands, with the aim of exploring geographical, climatic and natural vs anthropogenic gradients. Annual average fluxes of global deposition, discriminating insoluble (3,5-20,7 g m-2 year-1) and soluble-inorganic (7,1-45,5 g m-2 year-1) aerosols are discussed, seasonal patterns are regarded, and an attempt to estimate the impact of the main sources is presented. The wide range of atmospheric deposition fluxes (DF) regarding soluble (DFSOL) and insoluble (DFINS) has been investigated taking into consideration the contribution from nearby to long-distance sources, such as African dust, or regional-to-nearby ones, which include agricultural dust in the Ebro Valley, industrial emissions at different parts, urban dust at all cities, or saline dust resuspension from a dissicated lake bed. DFSOL is made up of marine aerosols, prevailing in coastal areas, with few exceptions in the Ebro Valley; nitrogen-species, homogeneously distributed across the network, with few exceptions due to agricultural sources; mineral dust, enhanced in the Ebro Valley owing to regional and agricultural emissions; and phospathe, displaying comparable values to other studies in general, but three hotspots at regional background environments have been identified. DFINS particles followed the aridity pattern, especially where anthropogenic emissions take place. Our estimates indicate that the regional dust to DFINS in the Ebro Valley represented 23-30%, overpassing 50% at intensive agricultural areas. Similarly, urban-metropolitan contributions accounted for 37-45% at the four cities, and 55% at the industrial one. African dust deposition was enhanced in the Central Pyrenees (75-80%) as a result of the magnification of atmospheric washout processes, and in south-eastern Iberia (69%) owing to the higher frequency of dust outbreaks.

13.
Cureus ; 12(4): e7875, 2020 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-32489729

RESUMEN

Background Interstitial lung disease (ILD) is a common pathologic consequence of the idiopathic inflammatory myopathies, and it may be the initial presentation of autoimmune disease in many cases. There are no well-established guidelines to direct the evaluation of this disease in these cases. This study looked at the utility of four common serologic tests to screen for a myositis-associated ILD. Methods This is a single institution retrospective analysis of four common serologic tests (antinuclear antibody [ANA], creatine kinase [CK], aldolase, and anti-Sjögren's syndrome A [anti-SSA]) to detect a positive antibody on an extended myositis antibody panel. Results The serum aldolase was the most sensitive test to detect the presence of a positive antibody on an extended myositis antibody panel with a sensitivity of 54.5%. The anti-SSA was the least sensitive at 21.4%. A positive result for anti-SSA antibodies was associated with a 100% positive predictive value when all other screening tests (ANA, aldolase, and CK) were also positive.  Conclusion No single screening test was sufficient for the evaluation of a myositis-associated ILD. A positive serum aldolase had higher sensitivity, and a positive SSA had a high positive predictive value when other screening markers were also elevated, but clinicians still need to maintain a high index of suspicion for myositis-associated ILD.

14.
Cureus ; 12(2): e7078, 2020 Feb 22.
Artículo en Inglés | MEDLINE | ID: mdl-32226679

RESUMEN

Active learning improves self-reported engagement and satisfaction in medical education. Audience response systems are one mechanism of encouraging participation, especially in a setting in which learners in varying educational levels are present. Three fellowships participated in this educational quality improvement project where Poll Everywhere® was incorporated into didactics. Attendees were invited to complete a 4-question retrospective pre-post satisfaction survey. Incorporation of the Poll Everywhere® audience response system resulted in a shift in more favorable satisfaction scores and self-perceived attentiveness compared to the pre-intervention responses.

15.
Rev. esp. cardiol. (Ed. impr.) ; 72(9): 749-759, sept. 2019. tab, graf
Artículo en Español | IBECS | ID: ibc-189134

RESUMEN

La mejora en la supervivencia de los pacientes con cáncer ha puesto de manifiesto el impacto clínico que la cardiotoxicidad tiene en el pronóstico tanto cardiovascular como onco-hematológico, sobre todo cuando motiva la interrupción de terapias antitumorales altamente eficaces. La fibrilación auricular es una complicación frecuente en pacientes con cáncer activo y su tratamiento supone un gran reto. Estos pacientes tienen mayores riesgos tromboembólico y hemorrágico y, sin embargo, no se dispone de escalas específicas para guiar la atención clínica. El objetivo de este documento promovido por los grupos de Cardio-Onco-Hematología y Trombosis de la Sociedad Española de Cardiología y elaborado de manera conjunta con las diferentes áreas de conocimiento de la Sociedad Española de Cardiología y con expertos de la Sociedad Española de Oncología Médica, la Sociedad Española de Oncología Radioterápica y la Sociedad Española de Hematología y Hemoterapia, es proporcionar un enfoque multidisciplinario y práctico para la prevención y el tratamiento de la fibrilación auricular de pacientes con cáncer activo y basado en el consenso de expertos


Improvements in survival among cancer patients have revealed the clinical impact of cardiotoxicity on both cardiovascular and hematological and oncological outcomes, especially when it leads to the interruption of highly effective antitumor therapies. Atrial fibrillation is a common complication in patients with active cancer and its treatment poses a major challenge. These patients have an increased thromboembolic and hemorrhagic risk but standard stroke prediction scores have not been validated in this population. The aim of this expert consensus-based document is to provide a multidisciplinary and practical approach to the prevention and treatment of atrial fibrillation in patients with active cancer. This is a position paper of the Spanish Cardio-Oncology working group and the Spanish Thrombosis working group, drafted in collaboration with experts from the Spanish Society of Cardiology, the Spanish Society of Medical Oncology, the Spanish Society of Radiation Oncology, and the Spanish Society of Hematology


Asunto(s)
Humanos , Fibrilación Atrial/tratamiento farmacológico , Anticoagulantes/uso terapéutico , Neoplasias/complicaciones , Tromboembolia/prevención & control , Fibrilación Atrial/complicaciones , Antineoplásicos/uso terapéutico , Consenso , Pautas de la Práctica en Medicina
16.
Rev Esp Cardiol (Engl Ed) ; 72(9): 749-759, 2019 Sep.
Artículo en Inglés, Español | MEDLINE | ID: mdl-31405794

RESUMEN

Improvements in survival among cancer patients have revealed the clinical impact of cardiotoxicity on both cardiovascular and hematological and oncological outcomes, especially when it leads to the interruption of highly effective antitumor therapies. Atrial fibrillation is a common complication in patients with active cancer and its treatment poses a major challenge. These patients have an increased thromboembolic and hemorrhagic risk but standard stroke prediction scores have not been validated in this population. The aim of this expert consensus-based document is to provide a multidisciplinary and practical approach to the prevention and treatment of atrial fibrillation in patients with active cancer. This is a position paper of the Spanish Cardio-Oncology working group and the Spanish Thrombosis working group, drafted in collaboration with experts from the Spanish Society of Cardiology, the Spanish Society of Medical Oncology, the Spanish Society of Radiation Oncology, and the Spanish Society of Hematology.


Asunto(s)
Fibrilación Atrial/complicaciones , Cardiología , Consenso , Oncología Médica , Neoplasias/complicaciones , Sociedades Médicas , Tromboembolia/prevención & control , Anticoagulantes/uso terapéutico , Humanos , Factores de Riesgo , España , Tromboembolia/etiología
17.
Rev. esp. quimioter ; 32(3): 263-267, jun. 2019. tab
Artículo en Inglés | IBECS | ID: ibc-188520

RESUMEN

OBJECTIVES: No data on resistance to HIV integrase strand transfer inhibitors (InSTIs) in Argentina are available as access to these drugs and to integrase genotypic resistance test is limited. We aimed to evaluate the clinical profile of patients who underwent an integrase genotypic resistance test, prevalence of InSTI resistance mutations and predicted efficacy of raltegravir, elvitegravir and dolutegravir in our country. PATIENTS AND METHODS: Retrospective multicentric pilot survey from January 2011 to November 2017 of InSTI-failing patients assisted at two private and one public healthcare institutions located in Buenos Aires city, Argentina. RESULTS: Sixty seven patients were included. Patients had a median of 5 (4-7) prior treatments. All patients had InSTI-containing regimens (median exposure of 22.5 months); 94% were under raltegravir therapy and 71.9% had InSTI-resistance mutations. Predominant major mutations were N155H (35.1%), Q148H/R (15.8%) and G140A/S (14%). Considering Stanford HIVdb program, extremely low and identical activity of raltegravir and elvitegravir was described while dolutegravir remained either partially or fully active in 97.7% of patients. CONCLUSIONS: Integrase resistance test was prescribed almost exclusively in heavily pretrated raltegravir-exposed patients. The three main mutational pathways were described, with a predominance of N155H. Despite almost null susceptibility and extensive cross resistance was shown among raltegravir and elvitegravir, dolutegravir remains active in the majority of patients


OBJETIVOS: No hay datos disponibles sobre resistencia a inhibidores de la integrasa (INIs) en Argentina, ya que el acceso a estas drogas y al estudio de resistencia genotípica es limitado. Nuestro objetivo fue evaluar el perfil clínico de los pacientes a los que se les indicó un estudio de resistencia genotípico de integrasa, la prevalencia de mutaciones de resistencia INIs y la predicción de eficacia para raltegravir, elvitegravir y dolutegravir en nuestro país. PACIENTES Y MÉTODOS: Encuesta piloto retrospectiva multicéntrica, enero de 2011 a noviembre de 2017, de pacientes con fallo virológico a INIs asistidos en dos instituciones de salud privadas y una pública en Buenos Aires, Argentina. RESULTADOS: Se incluyeron 67 pacientes, con una mediana de 5 (4-7) tratamientos previos. Todos tenían regímenes con INIs (exposición media de 22,5 meses); el 94% estaba recibiendo raltegravir y el 71,9% tenía mutaciones de resistencia a INIs. Las mutaciones primarias predominantes fueron N155H (35,1%), Q148H/R (15,8%) y G140A/S (14%). Considerando el programa de HIVdb de la Universidad de Stanford, se describió una actividad extremadamente baja e idéntica para raltegravir y elvitegravir, mientras que dolutegravir se mantuvo parcial o totalmente activo en el 97,7% de los pacientes. CONCLUSIONES: La prueba de resistencia a la integrasa se indicó casi exclusivamente en pacientes experimentados en tratamiento antirretroviral y expuestos a raltegravir. Se describieron las vías mutacionales principales, con predominio de N155H. Pese a la susceptibilidad casi nula y extensa resistencias cruzada entre raltegravir y elvitegravir, dolutegravir permaneció activo en la mayoría de los pacientes


Asunto(s)
Humanos , Masculino , Femenino , Adulto Joven , Adulto , Persona de Mediana Edad , Farmacorresistencia Viral , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/virología , Inhibidores de Integrasa VIH/farmacología , Compuestos Heterocíclicos con 3 Anillos/uso terapéutico , Proyectos Piloto , Prevalencia , Quinolonas/farmacología , Quinolonas/uso terapéutico , Estudios Retrospectivos , Encuestas y Cuestionarios , Población Urbana , Carga Viral , Argentina/epidemiología , VIH/efectos de los fármacos , VIH/genética , Infecciones por VIH/epidemiología , Inhibidores de Integrasa VIH/uso terapéutico , Compuestos Heterocíclicos con 3 Anillos/farmacología
18.
Rev. port. enferm. saúde mental ; (20): 19-26, dez. 2018. tab
Artículo en Español | LILACS-Express | BDENF - Enfermería | ID: biblio-1099214

RESUMEN

CONTEXTO: La cultura cada vez más coercitiva en la atención a la salud mental se pone de manifiesto en multitud de intervenciones. Es preciso tomar en consideración las aportaciones de los profesionales de salud mental como procedimiento de evaluación y determinación de factores estratégicos en la facilitación hacia un cambio de paradigma. OBJETIVO: Analizar el discurso grupal en base a las opiniones, experiencias y percepciones de las enfermeras sobre la coerción y sus límites con los valores profesionales en el ámbito de los cuidados en salud mental. MÉTODO: Estudio descriptivo de enfoque cualitativo, donde participaron once enfermeras involucradas en el proceso formativo/docente de la especialidad de enfermería de salud mental. La recolección de datos se produjo a través de la técnica de grupo focal y el contenido textual ha sido sometido al análisis temático. RESULTADOS: Las categorías temáticas identificadas son: “Coerción: contexto de descubrimiento y contexto de justificación”, “Cuidado humano, vulnerabilidad y coerción en salud mental” y “Fortalezas y debilidades del cuidado profesional”. CONCLUSIÓN: Los valores y actitudes emergentes de las enfermeras especialistas en salud mental se articulan en la relación de ayuda, siendo la propia identidad enfermera el resultado de esa práctica y teniendo como principal característica la gestión integral del cuidado. Los cuidados enfermeros contribuyen a la consecución práctica de los derechos humanos. El cuidado contractual supone la negación de hacerse partícipe de prácticas obligatorias o coercitivas, tratándose de incorporar en una lógica de derecho la complejidad del cuidado.


CONTEXTO: A cultura cada vez mais coercitiva da atenção em saúde mental é evidente em diversas intervenções. É preciso ter em consideração as contribuições dos profissionais da saúde mental como procedimento de avaliação e determinação de fatores estratégicos na facilitação da mudança de paradigma. OBJETIVO: Analisar o discurso grupal com base nas opiniões, experiências e percepções das enfermeiras sobre a coerção e os seus limites com os valores profissionais no âmbito dos cuidados em saúde mental. MÉTODOS: Estudo descritivo com uma abordagem qualitativa, onde participaram onze enfermeiras envolvidas no processo de formação e a docência da especialidade de enfermagem de saúde mental. A colheita de dados foi realizada através da técnica de grupo focal e o conteúdo textual foi submetido à análise temática. RESULTADOS: As categorias temáticas identificadas são: “Coerção: contexto de descoberta e contexto de justificação”, “Do cuidado humano, vulnerabilidade e coerção em saúde mental” e “Fortalezas e debilidades do cuidado profissional”. CONCLUSÃO: Os valores e atitudes emergentes das enfermeiras especialistas em saúde mental dependem da relação de ajuda, sendo a própria identidade da enfermeira o resultado dessa prática e tendo como principal característica a gestão integral do cuidado. Os cuidados de enfermagem contribuem à consecução prática dos direitos humanos. O cuidado contratual supõe a negação de fazer-se participante de práticas obrigatórias ou coercitivas, tratando-se de incorporar em uma lógica de direito a complexidade do cuidado.


BACKGROUND: Increasingly coercive culture in mental health care clearly comes out in a multitude of interventions. It is necessary to take into consideration the contributions of mental health professionals to evaluate and determine strategic factors to facilitate a paradigm shift. AIM: Analysis of group discourse based on the opinions, experiences and perceptions of nurses about coercion and its limits, with professional values in the field of mental health care. METHODS: Descriptive study from a qualitative approach with the participation of eleven nurses involved in the teaching- learning process about specialises in mental health. Data collection was done through the focus group technique and textual content has been subjected to thematic analysis. RESULTS: The thematic categories identified are: "Coercion: context of discovery and context of justification", "Human care, vulnerability and coercion in mental health" and "Strengths and weaknesses of professional care". CONCLUSION: Values and emerging attitudes of nurses specialized in mental health are based on aid relationships. The own nurse identity is the result of this practice and the integral management of care is the main feature. Nursing care contributes to the practical achievement of human rights. Contractual care implies the refusal to participate in compulsory or coercive practices, trying to understand the complexity of care under a logic of law.

19.
Food Sci Nutr ; 6(4): 1138-1145, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29983978

RESUMEN

Iron and zinc deficiencies are global health problems, affecting mostly pregnant women and young children. In 2016, biofortified iron and zinc beans were introduced in Colombia. The incorporation of biofortified beans into the national school-feeding program could facilitate adoption and potentially improve the nutritional status of large populations. However, biofortified beans have to be accepted in order to be consumed by populations. We therefore studied the sensory acceptability of two biofortified beans, BIO-101 and BIO-107, and local beans at schools with free feeding services in two departments of southwest Colombia. Measured on a five-point Likert scale, the mean overall scores were 3.88 ± 0.64, 3.79 ± 0.74, and 3.81 ± 0.76, for BIO-101, BIO-107, and the local bean varieties, respectively, without significant differences. The children in Piendamó (Cauca) slightly preferred BIO-107 over the local bean (p < .05) based on color, smell, and taste. The children in Caicedonia (Valle del Cauca) slightly favored the local bean over BIO-107 (p < .05), regarding size, smell, and taste. Overall acceptability in schoolchildren was good for all beans without significant differences. This study advocates incorporation of accepted biofortified beans in the school-feeding program, in order to reach large groups of schoolchildren and potentially improve their nutritional statuses.

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