RESUMEN
Rasmussen's encephalitis (RE) stands as a rare neurological disorder marked by progressive cerebral hemiatrophy and epilepsy resistant to medical treatment. Despite extensive study, the primary cause of RE remains elusive, while its histopathological features encompass cortical inflammation, neuronal degeneration, and gliosis. The underlying molecular mechanisms driving disease progression remain largely unexplored. In this case study, we present a patient with RE who underwent hemispherotomy and has remained seizure-free for over six months, experiencing gradual motor improvement. Furthermore, we conducted molecular analysis on the excised brain tissue, unveiling a decrease in the expression of cell-cycle-associated genes coupled with elevated levels of BDNF and TNF-α proteins. These findings suggest the potential involvement of cell cycle regulators in the progression of RE.
Asunto(s)
Encefalitis , Humanos , Encefalitis/genética , Encefalitis/patología , Encefalitis/metabolismo , Masculino , Proteínas de Ciclo Celular/genética , Proteínas de Ciclo Celular/metabolismo , Encéfalo/patología , Encéfalo/metabolismo , Factor Neurotrófico Derivado del Encéfalo/genética , Factor Neurotrófico Derivado del Encéfalo/metabolismo , Corteza Cerebral/patología , Corteza Cerebral/metabolismo , Femenino , Factor de Necrosis Tumoral alfa/metabolismo , Factor de Necrosis Tumoral alfa/genética , Ciclo Celular/genéticaRESUMEN
A síndrome do túnel do carpo (STC) é a neuropatia periférica mais comum resultante da compressão do nervo mediano no punho, acometendo principalmente o sexo feminino entre a terceira e sexta década de vida. A sua manifestação clinica se manifesta por dor, parestesias e formigamento nas extremidades superiores, sendo uma causa cada vez mais reconhecida de incapacidade para o trabalho. O exame físico do paciente com STC possui sinais clássicos, como o sinal de Tinel,de Phalen e de Durkan (compressão do nervo mediano). O diagnóstico da STC é baseado no exame clínico e exame de eletroneuromiografia (padrão ouro) ou exames de imagem (com limitações) As formas de tratamento variam entre tratamento conservador e cirúrgico. No trabalho, os autores relatam breve revisão da patologia e suas formas de diagnóstico e tratamento.
The carpal tunnel syndrome (CTS) is the most common peripheralneuropathy resulting from compression of the mediannerve at the wrist, affecting mainly the female sex, between the third and sixth decade of life. Its clinical manifestations are pain, numbness and tingling in upper extremities, and anincreasingly recognized cause of incapacity for work. Physical examination of patients with CTS has classic signs such as Tinels , Phalens and Durkan signs (median nerve compression).The diagnosis of CTS is based on clinical examination and electromyography (gold standard) or imaging (with limitations).Treatment options range from conservative and surgical treatment. We report a brief review of this syndrome and its forms of diagnosis and treatment.