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1.
Cell Tissue Res ; 256(1): 191-7, 1989 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-2469539

RESUMEN

The intramural distribution of vasoactive intestinal polypeptide (VIP), substance P, somatostatin and mammalian bombesin was studied in the oesophago-gastro-pyloric region of the human gut. At each of 21 sampling sites encompassing this entire area, the gut wall was separated into mucosa, submucosa and muscularis externa, and extracted for radioimmunoassay. VIP levels in the mucosa were very high in the proximal oesophagus (1231 +/- 174 pmol/g, mean +/- SEM) and showed varied, but generally decreasing concentrations towards the stomach, followed by a clear-cut increase across the pyloric canal (distal antrum: 73 +/- 16 pmol/g, proximal duodenum: 366 +/- 62 pmol/g); consistent levels were found in submucosa and muscle (200-400 pmol/g) at most sites, the stomach again showing lower concentrations. By contrast, substance P was present in small amounts as far as the proximal stomach, but sharply increased across the pyloric canal, especially in mucosa and submucosa (distal antrum: 20 +/- 6.5 and 5.5 +/- 1.3 pmol/g; proximal duodenum: 62 +/- 8.5 and 34 +/- 11 pmol/g, respectively). Somatostatin concentrations were very low in the mucosa of the oesophagus and stepwise increased in the cardiac, mid-gastric and pyloric mucosa (cardia: 224 +/- 72 pmol/g; distal antrum: 513 +/- 152 pmol/g; proximal duodenum: 1013 +/- 113 pmol/g); concentrations in the submucosa and muscularis were generally low, with the exception of antrum and duodenum. Mammalian bombesin was comparatively well represented throughout the oesophageal muscularis (5-8 pmol/g), but most abundant in the stomach in all layers (oxyntic mucosa: 24 +/- 2.7 pmol/g; submucosa: 20 +/- 5.7 pmol/g; muscle: 28 +/- 5.0 pmol/g).(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Bombesina/metabolismo , Unión Esofagogástrica/inervación , Píloro/inervación , Somatostatina/metabolismo , Sustancia P/metabolismo , Péptido Intestinal Vasoactivo/metabolismo , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fibras Nerviosas/metabolismo
2.
Appl Pathol ; 4(1-2): 98-103, 1986.
Artículo en Inglés | MEDLINE | ID: mdl-3580197

RESUMEN

A quantitative study of white pulp arterial vessels has been carried out in congestive splenomegaly with hypersplenism. Arteries and arterioles with periarterial lymphatic sheath (PALS) in abnormal spleens show an absolute volume and total length higher than in controls. Moreover, they present a luminal diameter significantly lower than normal. These findings demonstrate an increase of the white pulp arterial bed in congestive splenomegaly. Thus, the arteries with PALS participate in the complex vascular rearrangement which supports the blood hyperflow in congestive splenomegaly.


Asunto(s)
Hiperesplenismo/patología , Bazo/irrigación sanguínea , Esplenomegalia/patología , Hepatitis Crónica/patología , Humanos , Hipertensión Portal/patología , Cirrosis Hepática/patología
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