[Studies regarding the chronicization potential of viral hepatitis in children]. / Cercetari privind potentialul de cronicizare a hepatitei virale la copii.

Out of 205 children, former patients with viral hepatitis, investigated after the end of the follow-up period by clinical and laboratory examinations, 9 (4.4%) presented mild or moderate pathological alterations. At the second control, carried out after an another interval de 1-1½ years, the pathological alterations were refound only in 2 of the former patients, suggesting that all the others presented lasting forms of acute viral hepatitis evolving towards healing. The presence of AgHBs and the alteration of proteinogramme in the acute phase of VH can serve as criteria of unfavourable prognosis of the disease evolution and impose a preferential follow-up of this category of patients.

[Effectiveness of repeated antibiotic or chemotherapeutic treatments on Shigella carrier states]. / Consideratii privind eficienta repetarii tratamentului cu antibiotice sau chimioterapice asupra portajului de shigella

A group of 39 former dysentery patients, who continued to excrete Shigella bacteria after a first cure of antibiotics when full clinical recovery was obtained, were treated differentially under bacteriological control. The carrier state was still extent in 7% of the cases after three antibiotic or chemotherapeutical cures. No direct relation was found between the sensitivity of Shigella to chemotherapeutics and the level of the carrier state. Although treated already in the acute stage with adequate antibiotics, resistance to a second therapeutical attempt was recorded in a proportion of 33%. It is considered useless to repeat the antibiotic or chemotherapeutical cures in the treatment of convalescent carriers because of the low efficiency and the biological and economical disadvantages.