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1.
Neurochirurgie ; 56(5): 401-3, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20591451

RESUMEN

Extradural meningiomas account for approximately 7% of all spinal meningiomas and are most commonly located in the thoracic spine. Although rare, they should be included in the differential diagnosis of an extradural contrast-enhancing mass. Prognosis depends greatly on the extent of surgical resection. If considered safe, complete resection should be attempted to decrease the risk of recurrence. We report a case of spinal epidural meningioma diagnosed in an elderly woman complaining of right cervicobrachial pain of several years duration, associated with diffuse paresthesia and permanent numbness of her right index finger. The surgical removal of the tumor was incomplete because of the deep lateral extension of the lesion.


Asunto(s)
Neoplasias Epidurales , Meningioma , Anciano , Vértebras Cervicales , Neoplasias Epidurales/diagnóstico , Neoplasias Epidurales/cirugía , Femenino , Humanos , Meningioma/diagnóstico , Meningioma/cirugía , Vértebras Torácicas
3.
Acta Neurochir (Wien) ; 150(6): 589-93, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18431530

RESUMEN

We report on a young woman operated for a ganglioglioma involving the right auditory cortex (AC), presenting with auditory seizures. Despite a normal pre-operative examination, a specific post-operative disorder affecting the perception of a human voice occurred. The patient was unable to recognise the tone of familiar voices while she recognised the expressed content. A temporal lobectomy for recurrence was performed two years later. The patient recovered from the voice perception deficit. This report shows that (1) a discrete site within the AC is specifically involved in the perception of tone of the human voice (2) functional compensation is possible.


Asunto(s)
Corteza Auditiva/cirugía , Trastornos de la Percepción Auditiva/etiología , Neoplasias Encefálicas/cirugía , Dominancia Cerebral/fisiología , Ganglioglioma/cirugía , Complicaciones Posoperatorias/etiología , Acústica del Lenguaje , Calidad de la Voz , Lobectomía Temporal Anterior , Corteza Auditiva/fisiopatología , Trastornos de la Percepción Auditiva/diagnóstico , Trastornos de la Percepción Auditiva/fisiopatología , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/fisiopatología , Estudios de Seguimiento , Ganglioglioma/diagnóstico , Ganglioglioma/fisiopatología , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Recurrencia Local de Neoplasia/diagnóstico , Recurrencia Local de Neoplasia/fisiopatología , Recurrencia Local de Neoplasia/cirugía , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/fisiopatología , Recuperación de la Función/fisiología , Reoperación
4.
Nucleic Acids Res ; 29(11): 2314-26, 2001 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-11376150

RESUMEN

Methylation of CpG motifs in DNA is involved in the control of gene expression and in several other epigenic effects. It suppresses also the immuno-stimulation properties of bacterial or viral DNAs that contain CPGS: However, effects of methylation on the DNA structure and dynamics are not clear. Here we carried out a 10 ns MD simulation, confronted to an NMR analysis, of a hexadecanucleotide with the cAMP responsive element (CRE) DNA methylated at its center: d(GAGATGAmCGTCATCTC)(2) (CREmet). Methylation does not introduce significant structure modification but reduces the dynamics. Molecular mechanics and generalized Born solvation energy calculations showed that the stiffness of CREmet arises from both a restriction of the conformational space by the bulky methyl groups and a folding of DNA around the hydrophobic methyls. The latter effect is favored when the GpA steps belonging to the TGA binding half-sites adopt the BII conformation. The inability of the methylated DNAs to interact with their protein partners-either transcription factors for gene regulation or a Toll-like receptor for immunostimulation-could result from both the obstacle created by methyls, preventing crucial interactions, and the loss of DNA flexibility, reducing its adaptability. Results are discussed in the light of NMR and crystallographic data.


Asunto(s)
Islas de CpG/genética , AMP Cíclico/metabolismo , Metilación de ADN , ADN/química , Elementos de Respuesta/genética , Secuencia de Bases , Proteína de Unión a Elemento de Respuesta al AMP Cíclico/química , Proteína de Unión a Elemento de Respuesta al AMP Cíclico/genética , Proteína de Unión a Elemento de Respuesta al AMP Cíclico/metabolismo , ADN/metabolismo , Espectroscopía de Resonancia Magnética , Estructura Molecular , Conformación de Ácido Nucleico , Oligonucleótidos/química , Oligonucleótidos/metabolismo , Solubilidad , Termodinámica
6.
Eur J Biochem ; 259(3): 877-86, 1999 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10092877

RESUMEN

The cAMP-responsive element (CRE, 5'-TGACGTCA-3') is essential to the transcriptional function of numerous gene promoters in eukaryotic cells. We carried out NMR restrained molecular mechanics studies using two different force fields (Flex and "AMBER94") on a hexadecanucleotide d(GAGATGACGTCATCTC) containing CRE. Results indicated that free CRE is a B-DNA that is intrinsically curved towards the minor groove. To our knowledge, NMR restraints have not previously been useful in accounting for a global DNA curvature. In order to validate the bend in CRE, we applied a new strategy in which DNA structures displaying different curvatures were generated and then compared with NMR data. Conformations of CRE curved towards the minor groove provided the best agreement with NMR data. Our results contrast with previous results obtained from NMR restrained modelling and gel methods; these suggested conformations that were straight or curved towards the major groove, respectively. The curve in free CRE is spread along the DNA helix: several kinks are repeated in phase within the helical turn, although they are centred mainly on CpG in between the TGA half-sites, thus slightly increasing their spacing within the major groove. Comparison with the crystal structure of CRE complexed to general control protein 4 showed that the curve orientation is reversed from the minor to the major groove upon protein binding, due to a helix distortion concentrated mainly on CpG.


Asunto(s)
AMP Cíclico/genética , Conformación de Ácido Nucleico , Oligodesoxirribonucleótidos/química , Secuencias Reguladoras de Ácidos Nucleicos/genética , Proteínas de Saccharomyces cerevisiae , Proteínas de Unión al ADN/química , Proteínas Fúngicas/química , Espectroscopía de Resonancia Magnética , Modelos Moleculares , Conformación Molecular , Proteínas Quinasas/química , Programas Informáticos
7.
J Radiol ; 78(1): 61-4, 1997 Jan.
Artículo en Francés | MEDLINE | ID: mdl-9091623

RESUMEN

We report a case of traumatic duodenal hematoma. The patient's age (2.5 y.) and the absence of evidence of trauma when the symptoms began led to perform plain films of the abdomen, upper GI series, US, CT, and MR. This excess of imaging modalities emphasize the diagnostic value of plain X Rays of the abdomen and opacification of the duodenum.


Asunto(s)
Traumatismos Abdominales/complicaciones , Enfermedades Duodenales/etiología , Hematoma/etiología , Factores de Edad , Preescolar , Enfermedades Duodenales/diagnóstico , Enfermedades Duodenales/diagnóstico por imagen , Hematoma/diagnóstico , Hematoma/diagnóstico por imagen , Humanos , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada por Rayos X , Heridas no Penetrantes/complicaciones
8.
Behav Genet ; 21(4): 421-9, 1991 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-1953603

RESUMEN

Screening for handedness was performed in 11 inbred strains of mice. Direction and degree of handedness were measured for both males and females in each strain. The data show that there are almost as many right- as left-handed subjects and no strain could be classified as right- or left-handed. Females, however, tend to be more strongly lateralized than males. The range of variation for degree of handedness is pronounced between strains. These results thus suggest that degree of handedness would be the relevant variable in a genetic analysis of handedness in mice. They are in agreement with Collins' previous results showing a response to selection for degree, but not for direction, of handedness.


Asunto(s)
Lateralidad Funcional/genética , Ratones Endogámicos/genética , Animales , Femenino , Masculino , Ratones , Desempeño Psicomotor , Caracteres Sexuales , Especificidad de la Especie
9.
Physiol Behav ; 49(4): 701-4, 1991 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-1881972

RESUMEN

Mice from a pool of inbred strains (384 males and 329 females) were tested for handedness according to Collins' protocol in order to assess the reliability of this measurement. As previously reported by Collins these data revealed that a) approximately half of the mice were right-handed and half left-handed, b) most of the mice were strongly lateralized and c) females were more lateralized than males. The study of the psychometric characteristics of the test suggested that this measurement of behavioral asymmetry is both stable and observer independent. The test of paw preference also appeared to measure preexisting lateralization and was not a function of training during the test.


Asunto(s)
Dominancia Cerebral/genética , Ratones Endogámicos/genética , Animales , Conducta Apetitiva/fisiología , Corteza Cerebral/fisiología , Dominancia Cerebral/fisiología , Femenino , Masculino , Ratones , Ratones Endogámicos/fisiología , Desempeño Psicomotor/fisiología , Caracteres Sexuales , Especificidad de la Especie
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