Influence of chemoradiotherapy on nutritional status, functional capacity, quality of life and toxicity of treatment for patients with cervical cancer.

AIM: Assess the influence of chemoradiotherapy on the nutritional status, functional capacity and quality of life (QoL), associating these indicators at baseline with toxicity and interruption of oncologic treatment in women with cervical cancer. METHODS: Prospective cohort study performed on 49 women diagnosed with cervical cancer, who underwent treatment between August 2015 and January 2016. For data collection, two appointments were conducted by the lead researcher: the first occurred the day before the first chemotherapy session (T0) and the other at the end of chemotherapy session (T1). Nutritional status was measured by anthropometry (weight, height, mid-upper arm circumference and triceps skinfold thickness) and computed tomography (skeletal muscle index-SMI), functional capacity by handgrip strength (HGS) and Karnofsky Performance Status (KPS), and application of QoL questionnaire (EORTC QLQ-C30). RESULTS: The average age was 45 ± 13.8 years and 81.6% of the women were diagnosed in stages II and III. There was significant reduction in HGS, KPS and QoL between T0 and T1, in addition to a significant QoL reduction according to worsening nutritional status. The interruption of chemotherapy was significantly associated with the variables of nutritional status assessed at baseline. Women who interrupted treatment due to acute toxicity also had a significant lower median SMI than those who concluded the treatment and 83% of these patients presented cachexia. CONCLUSIONS: Chemoradiotherapy treatment in patients with cervical cancer had changed negative nutritional parameters, function capacity and QoL, and poor nutritional status at baseline was associated with chemotherapy interruption.

Vitamin A liver store: a case-control study.

The present study aims to assess the vitamin A liver store in individuals who died of several causes and to compare them with those who died of violent causes. A case-control study was performed with 60 individuals, where 30 died of violent causes (control) and 30 of other causes (cardiovascular diseases, infections, other chronic degenerative diseases, several causes). According to the cause of death, the mean retinol from liver stores was 281.5 +/- 63.50 mg/g for individuals who died of violent causes--a significantly higher amount (P < 0.05) than those observed in the other group (105.4 +/- 87.54 mg/g by cardiovascular diseases, 88.1 +/-78.03 mg/g by infections, 162.4 +/- 119.19 mg/g by other chronic degenerative diseases and 205.5 + 126.63 mg/g by several causes). The highest prevalence of low vitamin A was observed in individuals who died of infections and cardiovascular diseases, which emphasizes the role of vitamin A in these pathological processes.