[Using method of DNA microelectrophoresis for the assessment of genotoxic effects of mutagens in cultured human hemopoietic cells]. / Primenenie metoda mikroélektroforeza DNK dlia otsenki genotoksicheskikh éffektov mutagenov v kul'ture gemopoéticheskikh kletok cheloveka.

Formation of single- and double strand breaks in DNA which may be discovered by microelectrophoresis in agarose gel is one of the criterion of genetical lesions in cells as a result of apoptosis or of genotoxic agent action. Genotoxic action of nickel chloride at the level of DNA of the individual cells in the initial culture of human embryonic haemopoietic cells was studied. It has been shown that about 2% cells in the studied in vitro populations were in the apoptosis state. Nickel chloride induced increasing of the frequency of formation of electrophoretic tracks of "comet" type with destroyed DNA.

[Pathogenetic characteristics of trigger mechanisms of preterm birth]. / Patohenetychna obumovlenist' puskovykh mekhanizmiv nedonoshuvannia vahitnosti.

A study was made into the immune factors capability to induce labour in physiologic delivery and in threat of preterm birth. The immune response reactivity was proved to be the case immediately before the physiological labour and in premature delivery. The studies made showed that a rise in the level of lymphocytes and in the subpopulations ratios is a matter of principle in the diagnosis and prognosis of the contractile activity of the uterus. Preclinical diagnosis of pregnancy suspension permit performing a rational drug correction to secure a positive effect on indices for perinatal pathology.