RESUMEN
The thermal condensation of diethyl 3,4-methylenedioxyphenylmalonate with 3,5-dimethoxyphenol (di-O-methylphloroglucinol) leads to the corresponding 3-(3,4-méthylenedioxyphenyl)-4-hydroxy-5,7-dimethoxycoumarine which is methylated further into derrusnine.
Asunto(s)
4-Hidroxicumarinas/síntesis química , Indicadores y Reactivos , Espectroscopía de Resonancia Magnética , Espectrofotometría InfrarrojaRESUMEN
The study of the relative binding affinity to steroïd hormonal receptors and of the antiproliferative action on MCF-7 cells of 3-arylcoumarines, 3-aryl-4-hydroxycoumarines, isoflavanones, isoflavan-4-ols and isoflavones, indicates a weak activity in the case of some representatives of coumarines.
Asunto(s)
Cumarinas/farmacología , Isoflavonas/farmacología , Receptores de Progesterona/metabolismo , Receptores de Esteroides/metabolismo , Adrenalectomía , Animales , Neoplasias de la Mama , División Celular/efectos de los fármacos , Cumarinas/farmacocinética , Femenino , Humanos , Isoflavonas/farmacocinética , Riñón/metabolismo , Masculino , Ratas , Receptores de Estrógenos/metabolismo , Receptores de Glucocorticoides/metabolismo , Receptores de Mineralocorticoides/metabolismo , Proteínas Recombinantes/metabolismo , Relación Estructura-Actividad , Timo/metabolismo , Células Tumorales CultivadasRESUMEN
The study of the relationships between the structure and the free radical scavenging activity of substituted 4-hydroxycoumarine derivatives, indicates the favorable effect of electron donating substituents.