RESUMEN
Stereoselective synthesis of squalamine dessulfates analogues, 7 alpha and 7 beta-N-[3N-(4-aminobutyl) aminopropyl]aminocholesterol are reported, using 7 alpha and 7 beta-aminocholesterol as a key intermediate. It's the first example in which the position of spermidine is modified at the steroid ring. These molecules showed a comparable antibacteria and fungi activities to squalamine. Then, they have a cytotoxic activity on a human non-small cell bronchopulmonary carcinoma line (NSCLC-N6).
Asunto(s)
Colestanoles/síntesis química , Antibacterianos/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Antifúngicos/síntesis química , Antifúngicos/química , Antifúngicos/farmacología , Neoplasias de los Bronquios/patología , Carcinoma de Pulmón de Células no Pequeñas/patología , Línea Celular Tumoral , Colestanoles/química , Colestanoles/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Neoplasias Pulmonares/patologíaRESUMEN
Homoallylamines, beta-amino esters, and beta-amino nitriles were obtained in a one-pot synthesis directly from an aldehyde and a secondary amine such as dibenzylamine or diallylamine. Their condensation with titanium(IV) isopropoxide generates an intermediate aminoalkoxy titanium complex. Further reaction in THF with nucleophilic organometallic species, generated in situ from indium or zinc and a reactive halide (allyl bromide, alkyl bromo- or iodoacetate, iodoacetonitrile), furnished the corresponding amines.
RESUMEN
Rural underserved areas can benefit from private and non governmental organizations in improving health delivery. Many such organizations operate in the underserved Bekaa area in Lebanon. This study aimed to assess the nature, scope, utilization and satisfaction with health services available to the population living in the vicinity of the American University of Beirut Agricultural Research and Education Center in Bekaa. A random sample from the residents of the area (475 individuals) and all physicians and representatives of health delivery institutions serving this population were interviewed. Individuals interviewed reported 3.7 health related visits/person/year, 65% vaccination rate and 34.1% labeled available services as poor. Interviewed physicians and health institution administrators identified the study area priority needs as nurses, emergency transport units and primary care centers. Systematic evaluation and priority setting of the health needs of this population are necessary and the establishment of health centers should be strongly considered.
