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1.
J Control Release ; 363: 180-200, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37739014

RESUMEN

Wound healing is a crucial process that restores the integrity and function of the skin and other tissues after injury. However, external factors, such as infection and inflammation, can impair wound healing and cause severe tissue damage. Therefore, developing new drugs or methods to promote wound healing is of great significance. Photothermal therapy (PTT) is a promising technique that uses photothermal agents (PTAs) to convert near-infrared radiation into heat, which can eliminate bacteria and stimulate tissue regeneration. PTT has the advantages of high efficiency, controllability, and low drug resistance. Hence, nanomaterial-based PTT and its related strategies have been widely explored for wound healing applications. However, a comprehensive review of PTT-related strategies for wound healing is still lacking. In this review, we introduce the physiological mechanisms and influencing factors of wound healing, and summarize the types of PTAs commonly used for wound healing. Then, we discuss the strategies for designing nanocomposites for multimodal combination treatment of wounds. Moreover, we review methods to improve the therapeutic efficacy of PTT for wound healing, such as selecting the appropriate wound dressing form, controlling drug release, and changing the infrared irradiation window. Finally, we address the challenges of PTT in wound healing and suggest future directions.


Asunto(s)
Nanocompuestos , Fototerapia , Fototerapia/métodos , Cicatrización de Heridas , Calor , Antibacterianos/farmacología , Antibacterianos/uso terapéutico
2.
Opt Express ; 27(26): 37180-37195, 2019 Dec 23.
Artículo en Inglés | MEDLINE | ID: mdl-31878503

RESUMEN

Zernike circular polynomials (ZCP) are widely used in optical testing, fabrication and adaptive optics. However, their ability to characterize information on spherical cap is often limited by aperture angle, with highly curved surface being particularly challenging. In this study, we propose a simple and systematic process to derive Zernike like functions that are applicable to all types of spherical cap. The analytical expressions of three function sets are calculated using Gram-Schmidt algorithm. They are hemispherical harmonics (HSH), Zernike spherical function (ZSF) and longitudinal spherical function (LSF). HSH satisfies Laplacian equation and composes a subset of spherical harmonics (SH). ZSF and LSF can be applied to arbitrary spherical cap and their orthogonality is invariant to aperture. The achieved functions, with their complete and orthogonal performance, can serve as essential tools for surface characterization required for a wide range of applications like large-angle lenses description in illumination design, aberration analysis in high aperture systems, human cornea measurement fitting, geomagnetic field modelling, etc. Moreover, they are important for graphics rendering in virtual reality and games by solving the reflectance equation efficiently.

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