RESUMEN
We analyzed HIV viral load (VL) and CD4 count changes, and antibody responses following MMR vaccination of individuals in the U.S. Military HIV Natural History Study cohort. Cases receiving at least one dose of MMR vaccine after HIV diagnosis were matched 1:2 to HIV-positive controls not receiving the vaccine. Baseline was defined as time of vaccination for cases and indexed and matched to the time post-HIV diagnosis for controls. Changes in CD4 count and VL at 6, 12, 18 and 24 months were compared between cases and controls using a general linear model. Available sera from cases were tested for MMR seropositivity at baseline and post-vaccination at 6, 12, 18, and 24 months. Overall mean CD4 count change from baseline through 24 months was 20 (±23) cells/µL greater for cases than controls (p=0.39). Similar non-significant changes in CD4 cell count were seen in the subset of those not on HAART at baseline. VL changes were small and similar between groups (mean differential change -0.04 (±0.18) log(10) copies/mL; p=0.84). Of 21 vaccinated participants with baseline serologic testing, 14 (67%) were reactive to measles, 19 (91%) to mumps, and 20 (95%) to rubella. Three (43%) of 7 participants nonreactive to measles developed measles IgG; for mumps, 1 (50%) of 2 developed mumps IgG; for rubella, 1 (100%) developed rubella IgG. MMR vaccination did not result in detrimental immunologic or virologic changes through 24 months post-vaccination.
Asunto(s)
Formación de Anticuerpos , Infecciones por VIH/inmunología , Vacuna contra el Sarampión-Parotiditis-Rubéola/administración & dosificación , Sarampión/prevención & control , Paperas/prevención & control , Rubéola (Sarampión Alemán)/prevención & control , Adulto , Análisis de Varianza , Anticuerpos Antivirales/sangre , Recuento de Linfocito CD4 , Estudios de Casos y Controles , Femenino , VIH-1/inmunología , Humanos , Masculino , Personal Militar , Estudios Retrospectivos , Estudios Seroepidemiológicos , Estados Unidos , Carga Viral , Adulto JovenRESUMEN
Hansen's disease (HD) continues to have worldwide impact despite efforts to eradicate the disease. Although a definitive transmission mode has not been identified, data supports an association between HD and contact with the nine-banded armadillo. We conducted a case-control study of 28 HD patients to determine if there is an association between armadillo exposure and HD. There was no association between HD and place of birth or having hunted, consumed, or had direct or indirect contact with deer, birds, or squirrels. Univariate analysis showed that residence in Mexico (P = 0.001), hunting rabbits (P = 0.04), cleaning rabbits (P < 0.001), and armadillo exposure from hunting (P = 0.005), cleaning (P = 0.004), consuming (P = 0.002) them, or having direct armadillo contact (P = 0.017) were associated with HD. Multivariate analysis showed that eating armadillos (P = 0.039, odds ratio [OR] = 3.65, 95% confidence interval [CI] = 1.07-12.4), cleaning rabbits (P = 0.018, OR = 4.08, 95% CI = 1.27-13.1), and having lived in Mexico (P = 0.006, OR = 24.9, 95% CI = 2.52-245) were associated with HD.
Asunto(s)
Armadillos/microbiología , Lepra/transmisión , Zoonosis , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Animales , Estudios de Casos y Controles , Femenino , Humanos , Lepra/epidemiología , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios , Estados Unidos/epidemiologíaRESUMEN
Drug-induced acute febrile neutrophilic dermatosis, or Sweet's syndrome, is rare and, to our knowledge, has not previously been associated with clindamycin therapy. We describe a 47-year-old woman with type 2 diabetes mellitus and end-stage renal disease requiring hemodialysis who developed Sweet's syndrome after receiving oral and intravenous clindamycin for a tooth infection. After the clindamycin was discontinued, the patient's clinical symptoms resolved over several days. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship between the patient's development of Sweet's syndrome and clindamycin therapy. Clinicians should be aware that Sweet's syndrome can occur with clindamycin treatment. Early recognition of this condition in conjunction with cessation of drug exposure, with or without antiinflammatory therapy, can produce complete recovery.
Asunto(s)
Antibacterianos/efectos adversos , Clindamicina/efectos adversos , Síndrome de Sweet/inducido químicamente , Administración Oral , Antibacterianos/administración & dosificación , Clindamicina/administración & dosificación , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Humanos , Inyecciones Intravenosas , Fallo Renal Crónico/complicaciones , Persona de Mediana Edad , Absceso Periapical/tratamiento farmacológico , Diálisis Renal , Extracción DentalAsunto(s)
Neurocisticercosis/diagnóstico , Estado Epiléptico/parasitología , Adulto , Antihelmínticos/uso terapéutico , Anticonvulsivantes/uso terapéutico , Edema Encefálico/tratamiento farmacológico , Edema Encefálico/parasitología , Edema Encefálico/patología , Femenino , Lóbulo Frontal/parasitología , Lóbulo Frontal/patología , Humanos , Imagen por Resonancia Magnética , Neurocisticercosis/tratamiento farmacológico , Lóbulo Parietal/parasitología , Lóbulo Parietal/patología , Estado Epiléptico/tratamiento farmacológico , Tomografía Computarizada por Rayos XRESUMEN
Serum sickness is a type III hypersensitivity reaction mediated by immune complex deposition with subsequent complement activation, small-vessel vasculitis, and tissue inflammation. Although the overall incidence of serum sickness is declining because of decreased use of heterologous sera and improved vaccinations, rare sporadic cases of serum sickness from nonprotein drugs such as penicillins continue to occur. Drug-induced serum sickness is usually self-limited, with symptoms lasting only 1-2 weeks before resolving. We report an unusual case of a severe and prolonged serum sickness reaction that occurred after exposure to an intramuscular penicillin depot injection (probable relationship by Naranjo score) and discuss how pharmacokinetics may have played a role. Clinicians should be familiar with serum sickness reactions particularly as they relate to long-acting penicillin preparations. Accurate diagnosis in conjunction with cessation of drug exposure and prompt initiation of antiinflammatory treatment with corticosteroids can produce complete recovery
Asunto(s)
Penicilinas/efectos adversos , Enfermedad del Suero/terapia , Administración Oral , Adulto , Femenino , Humanos , Inyecciones Intramusculares , Recuento de Leucocitos , Penicilina V/administración & dosificación , Penicilina V/efectos adversos , Penicilinas/administración & dosificación , Enfermedad del Suero/sangre , Enfermedad del Suero/fisiopatología , Tomografía Computarizada por Rayos XRESUMEN
Anabolic-androgenic steroids are synthetic derivatives of testosterone that some athletes have used to enhance muscle mass and improve their athletic performance. Ephedrine is a potent sympathomimetic agent that can lead to cardiomyopathy similar to that seen with catecholamine excess. Adverse cardiovascular events attributed to anabolic steroid and ephedra use, such as arrhythmias, myocardial infarction, cardiomyopathy, and sudden death, are rarely reported. Bodybuilders have used gamma-hydroxybutyrate, a potent secretagogue of growth hormone, to promote muscle development. Although dilated cardiomyopathy is a known complication of excess growth hormone levels, it has not been associated with use of gamma-hydroxybutyrate. A healthy 40-year-old man was admitted to our hospital for new-onset congestive heart failure and severe acute hepatitis that developed several months after he began using anabolic-androgenic steroids, ephedra, and gamma-hydroxybutyrate supplements. Analysis with an objective causality assessment scale revealed a probable adverse drug reaction between the patient's use of anabolic steroids, ephedra, and gamma-hydroxybutyrate and the development of his cardiomyopathy and acute liver injury.