1.
Ann Biol Clin (Paris)
; 42(1): 15-9, 1984.
Artículo
en Francés
| MEDLINE
| ID: mdl-6375471
RESUMEN
A modification of the serum gentamicin immunoenzymatic method (Syva- Biom erieux kit) for sisomicin assay is proposed and compared to the bacteriological reference method. It shows a higher sensitivity (0.1 mg.l-1) with a shortened time of analysis (less than 1 hour) and a good reproducibility (range: 4.7% to 1.6% for concentrations between 0.5 mg.l-1 and 10 mg.l-1) but the concentrations are 15 p. cent lower as compared to the bacteriological method. A pharmacokinetic study, performed in five patients, enables us to demonstrate the praticability of this method for the adaptation of the dosage regimen in renal insufficiency.