RESUMEN
Disruption of synaptic activity of a number of cerebral structures (e.g., neostriatum, amygdala, and thalamus) produces marked deficits in retention of instrumentally conditioned behaviors. When animals are given a relatively high number of training trials or high intensities of footshock during learning, however, such disruption is considerably less effective. Since there is a close anatomical and functional relationship between the neostriatum and the substantia nigra, it was of interest to determine whether enhanced training with a high level of footshock would prevent the reported amnesic state induced by injections of GABA antagonists into the latter structure. Rats were trained in a one-trial inhibitory task, using 0.2 or 0.4 mA, and then injected with microgram quantities of picrotoxin or bicuculline into the substantia nigra and posterior region of the zona incerta; retention was measured 24 h later. Only those groups that had been injected into the nigra and trained with 0.2 mA showed amnesia. These results support the hypotheses that (a) the normal activity of a set of structures is essential for the development of memory consolidation and (b) after an enhanced learning experience these structures may participate in memory consolidation, but are not necessary for the occurrence of this process.
Asunto(s)
Reacción de Prevención/efectos de los fármacos , Bicuculina/farmacología , Picrotoxina/farmacología , Sustancia Negra/efectos de los fármacos , Amnesia/inducido químicamente , Animales , Relación Dosis-Respuesta a Droga , Electrochoque , Masculino , Ratas , Ratas WistarRESUMEN
To test the hypothesis that cholinergic activity of the head of the caudate nucleus (CN) is involved in the processes underlying instrumental performance, the effects of microinjections of several doses of choline into this structure on lever pressing behavior were assessed. A dose-dependent modification of performance was found: small doses improve and large doses impair level pressing, while choline applications into the parietal cortex were without effect. The facilitatory effects were reproduced by microinjections of acetylcholine into the CN. These data further support our working hypothesis.