[Hyperthyroidism in childhood. Description of a case]. / L'ipertiroidismo nell'infanzia. Descrizione di un caso.

The authors report some personal clinical observations. The polymorphic clinical course, the diagnostic procedure and the therapeutical management of the infantile Grave's disease are discussed. Pathogenesis is not clarified. Genetic factors are also analysed.

[Alobar holoprosencephaly. Prenatal diagnosis and autopsy findings in 2 cases]. / Oloprosencefalia alobare. Diagnosi prenatale e reperti autoptici di due casi.

We report two patients with alobar holoprosencephaly and cebocephaly: one, a fetus at 20th week of gestation; the second, a new born who died at seven days of age. Its very important U.S.G. in the prenatal diagnosis. Patients with holoprosencephaly and extracephalic malformation warrant chromosome analysis, because the incidence of chromosomal anomalies is very high. In the first foetus the brain and the face anomalies were associated with omphalocele, ureteropathy, bifid and horned uterus. In the second child karyotype analysis was normal. Cranial C.A.T. scan is important in the new born for the differential diagnosis holoprosencephaly from hydranencephaly, ventriculomegalia and Dandy-Walker cyst. The encephalon autopsy of both patients showed the presence of a single ventricule, the absence of interhemispheric fissure, of the corpus callosum and arrhinencephalia. This malformation complex is causally heterogeneous group. Chromosomal, autosomal recessive, autosomal dominant, and multifactorial mechanism have been invoked in humans; in animals it can be produced easily by a multitude of teratogenic agents. The two children reported are the first observation in the family. The etiology is presently unclear.

[2 cases of Kawasaki disease with increase of beta-2 thromboglobulin]. / Due casi di malattia di Kawasaki con aumento della beta-2 tromboglobina.

The authors report two cases of Kawasaki disease, in which both the classic symptomatology and an increase in the beta 2 thromboglobin were present. The antigens of histocompatibility do not appear similar either to those which are more frequent in the Japanese population or in the patients suffering from arterial occlusive disease and Takayasu arteritis. The prognosis for these patients appears to be favourable: vascular and heart damages have not been shown. The therapy by means of antiaggregating agents has given good results showing a regression of the symptoms and a normalization of the laboratory tests within a few months.