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Biomed Pharmacother ; 142: 112067, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34449310

RESUMEN

Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles.


Asunto(s)
COVID-19 , Mortalidad Hospitalaria , Hipertensión , Unidades de Cuidados Intensivos/estadística & datos numéricos , Metaloproteinasa 2 de la Matriz , Metaloproteinasa 9 de la Matriz , Factores de Edad , Índice de Masa Corporal , Brasil/epidemiología , COVID-19/sangre , COVID-19/diagnóstico , COVID-19/mortalidad , COVID-19/fisiopatología , Femenino , Humanos , Hipertensión/diagnóstico , Hipertensión/epidemiología , Masculino , Metaloproteinasa 2 de la Matriz/análisis , Metaloproteinasa 2 de la Matriz/sangre , Metaloproteinasa 9 de la Matriz/análisis , Metaloproteinasa 9 de la Matriz/sangre , Persona de Mediana Edad , Mortalidad , Valor Predictivo de las Pruebas , Pronóstico , Factores de Riesgo , SARS-CoV-2 , Índice de Severidad de la Enfermedad
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