Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 75
Filtrar
1.
Nutr Diabetes ; 10(1): 22, 2020 06 17.
Artículo en Inglés | MEDLINE | ID: mdl-32555148

RESUMEN

BACKGROUND/OBJECTIVES: To ascertain the effect on body weight of 14 days of bolus enteral feeding with mixed meal (MM) and electrolyte solution (ES) in ambulatory adults with type 2 diabetes and obesity, and also the safety and feasibility of using a modified, intraorally anchored enteral feeding tube for this purpose. SUBJECTS/METHODS: We conducted a randomized, crossover pilot trial with 16 participants. A 140 cm, 8-French feeding tube was placed in the jejunum under electromagnetic guidance and anchored intraorally. Participants were randomized to self-administer 120 mL 523 kJ (125 kcal) MM, or 50 kJ (12 kcal) ES four times/day for 14 days. After ≥14 days without the tube, participants crossed over to the other treatment. The primary outcome compared weight change between treatments. Thereafter, participants could elect to undergo additional MM cycles. Participants were encouraged to continue with all usual activities including eating ad lib throughout the study. RESULTS: Ten participants withdrew prior to completing two randomized 14-day cycles (4 social, 3 intolerant of anchor, and 3 intolerant of tube). Six participants were assessed for the primary outcome and showed no significant difference in weight loss between MM and ES (p = 0.082). For the secondary outcome of within-group weight loss, average weight loss from baseline was significant for MM but not for ES: -2.40 kg (95% CI: -3.78, -1.02; p = 0.008) vs. -0.64 kg (95% CI: -2.01, 0.74; p = 0.27). A total of 23 2-week cycles were completed (12 paired, 2 unpaired, and 9 additional), with no significant adverse events for 334 days of tube use. CONCLUSIONS: Repeated bolus nutrient administration via enteral feeding tube is associated with weight loss in adults with obesity and type 2 diabetes, with no significant difference seen between MM and ES feeds. The prototype device was safe, but requires development for further investigation into the effect of bolus jejunal feeding on weight and to improve acceptability.


Asunto(s)
Peso Corporal , Diabetes Mellitus Tipo 2/terapia , Nutrición Enteral/métodos , Obesidad/terapia , Adulto , Estudios Cruzados , Estudios de Factibilidad , Femenino , Humanos , Intubación Gastrointestinal/métodos , Yeyuno/cirugía , Masculino , Comidas , Persona de Mediana Edad , Proyectos Piloto , Resultado del Tratamiento , Pérdida de Peso , Adulto Joven
2.
J Hosp Infect ; 86(2): 100-9, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24268365

RESUMEN

BACKGROUND: Healthcare- and hospital-acquired infection increases patients' morbidity and mortality and increases healthcare costs. Infection prevention and control is a high priority for medical professionals in healthcare settings. AIM: To identify essential infection prevention and control competencies for newly graduated nurses. METHODS: Three phases of research were designed: phase I, Instrument development, which was undertaken from January to May 2008; phase II, Expert panel identification, for which 122 experts were recruited, each nominated by presidents of infection control bodies and heads of nursing schools in Australia (N = 60) and Taiwan (N = 62); and phase III, Delphi surveys, which were conducted in three rounds simultaneously in Australia and Taiwan between July 2008 and May 2009. FINDINGS: Ninety-three experts returned the first questionnaire. Response rates of 76.2%, 91.4% and 94.1% were achieved in rounds I, II and III, respectively. Eighty experts participated in all three rounds. Overall, 81 items reached consensus, including seven in the competency area of basic microbiology, 12 in hand hygiene, 30 in standard precautions and additional precautions, 12 in personal protective equipment, nine in cleaning, disinfection and sterilization and 11 in critical assessment skills. The majority of experts (N = 49; 75.4%) agreed that infection control competency levels of newly graduated nurses were inadequate. CONCLUSION: Eighty-one items of infection prevention and control specific to newly graduated nurses were identified by consensus between expert panellists from Taiwan and Australia. Baseline data from this study may help to develop undergraduate nursing curricula to facilitate nurses' clinical application of infection control principles.


Asunto(s)
Educación en Enfermería/métodos , Conocimientos, Actitudes y Práctica en Salud , Control de Infecciones/métodos , Enfermeras y Enfermeros , Competencia Profesional/estadística & datos numéricos , Australia , Humanos , Taiwán
3.
Int Nurs Rev ; 60(1): 96-102, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23406244

RESUMEN

BACKGROUND: It is a truism that nursing care must be informed by assessment, otherwise how can one know what care is required or that it has been successfully delivered? Yet, little is known about the process of comprehensive mental health nursing assessment in practice. If the education of mental health nurses is to be effective, it is essential that the key content of, and the processes involved in carrying out a mental health nursing assessment in practice are able to be articulated to learners. AIM: To identify the processes of assessment that occur in mental health nursing practice based on interviews with mental health nurses working in clinical and management roles in clinical areas. METHOD: Interviews were undertaken with 18 nurses who worked in inpatient and community mental health settings either as clinicians or managers. The nurses ranged from new graduates to those with more than 20 years of experience. FINDINGS AND DISCUSSION: Clear processes were reported to be involved in undertaking a comprehensive mental health nursing assessment in practice, with three main themes emerging during analysis. First is the importance of engaging the patient; second is tell me what the problem is? with one subtheme reconcile inconsistencies; and finally, the ongoing nature of the assessment process. CONCLUSION: Common processes emerged when the nurses described their individual approaches to undertaking comprehensive mental health assessment. The results have important policy implications for the educational preparation of mental health nurses, their ongoing supervision and further research into contemporary mental health nursing practice.


Asunto(s)
Actitud del Personal de Salud , Evaluación en Enfermería , Proceso de Enfermería , Enfermería Psiquiátrica/organización & administración , Australia , Humanos , Entrevistas como Asunto , Relaciones Enfermero-Paciente , Investigación Cualitativa
4.
J Psychiatr Ment Health Nurs ; 20(2): 150-5, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22404368

RESUMEN

Assessment is the foundation of mental health nursing practice, but little is known of how it is undertaken. This paper explores how mental health nurses describe the content of a comprehensive mental health nursing assessment. Eighteen nurses who worked in inpatient and community settings either as clinicians or managers, ranging from new graduates to nurses with greater than 20 years of experience, were interviewed and asked to describe the content of a comprehensive mental health nursing assessment. Transcribed interviews were analysed using a grounded theory methodology. The primary theme to emerge was one of variability. Most respondents hesitated and then identified different content areas that needed to be assessed as part of a comprehensive mental health nursing assessment. If the areas that are being assessed vary between nurses, then logically the types of interventions being offered will also vary. These results have implications for the education of nurses, their clinical practice, ongoing supervision and research into contemporary mental health nursing practice.


Asunto(s)
Trastornos Mentales/diagnóstico , Evaluación en Enfermería/métodos , Enfermería Psiquiátrica/métodos , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Evaluación en Enfermería/normas , Enfermería Psiquiátrica/normas , Investigación Cualitativa
5.
Aust J Prim Health ; 19(3): 184-9, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-22951281

RESUMEN

There is evidence for a team-based approach in the management of chronic disease in primary health care. However, the standard of care is variable, probably reflecting the limited organisational capacity of health services to provide the necessary structured and organised care for this group of patients. This study aimed to evaluate the impact of a structured intervention involving non-GP staff in GP practices on the quality of care for patients with diabetes or cardiovascular disease. A cluster randomised trial was undertaken across 60 GP practices. The intervention was implemented in 30 practices with staff and patients interviewed at baseline and at 12-15 months follow up. The change in team roles was evaluated using a questionnaire completed by practice staff. The quality of care was evaluated using the Patient Assessment of Chronic Illness Care questionnaire. We found that although the team roles of staff improved in the intervention practices and there were significant differences between practices, there was no significant difference between those in the intervention and control groups in patient-assessed quality of care after adjusting for baseline-level score and covariates at the 12-month follow up. Practice team roles were not significantly associated with change in Patient Assessment of Chronic Illness Care scores. Patients with multiple conditions were more likely to assess their quality of care to be better. Thus, although previous research has shown a cross-sectional association between team work and quality of care, we were unable to replicate these findings in the present study. These results may be indicative of insufficient time for organisational change to result in improved patient-assessed quality of care, or because non-GP staff roles were not sufficiently focussed on the aspects of care assessed. The findings provide important information for researchers when designing similar studies.


Asunto(s)
Técnicos Medios en Salud/organización & administración , Enfermedad Crónica/terapia , Manejo de la Enfermedad , Medicina General/organización & administración , Grupo de Atención al Paciente/organización & administración , Calidad de la Atención de Salud/normas , Técnicos Medios en Salud/normas , Territorio de la Capital Australiana , Diabetes Mellitus/terapia , Femenino , Medicina General/métodos , Humanos , Hipertensión/terapia , Modelos Lineales , Masculino , Persona de Mediana Edad , Modelos Organizacionales , Isquemia Miocárdica/terapia , Nueva Gales del Sur , Grupo de Atención al Paciente/normas , Satisfacción del Paciente , Evaluación de Programas y Proyectos de Salud , Nivel de Atención , Victoria , Recursos Humanos
6.
Surg Endosc ; 20(5): 783-6, 2006 May.
Artículo en Inglés | MEDLINE | ID: mdl-16544080

RESUMEN

BACKGROUND: The Bravo catheter-free pH monitoring system uses a capsule attached to the esophageal mucosa to detect acid exposure. Placement of the Bravo capsule is associated with intermittent chest pain in 50% of normal volunteers. The authors hypothesized that chest pain in this setting may be attributable to hypertensive esophageal contractions induced by the Bravo capsule. METHODS: The study population consisted of 40 consecutive patients with reflux symptoms who had stationary esophageal manometry within 1 h after Bravo capsule placement. The control group consisted of 40 patients with symptomatic gastroesophageal reflux disease (GERD) from a population of patients with foregut symptoms who were computer matched to the study group for age, sex, lower esophageal sphincter (LES) pressure, LES length, and 24-h pH composite score. The patients in the control group had manometry before Bravo capsule placement. The occurrence of chest pain was assessed before and during the monitoring period by interview and review of the patient's diary. Mean contraction amplitudes in the distal third of the esophagus after 10 wet swallows were averaged. The prevalence of patients with esophageal contraction amplitudes in the distal third that exceeded the 95th percentile of normal (180 mmHg) and the mean amplitude of distal third esophageal contractions in the study and control populations were compared. In the study group, the incidence of chest pain among the patients with hypercontractility of the esophagus was compared with the incidence among those without hypercontractility. RESULTS: The mean contraction amplitude was higher in the study group (144.7 vs 105.5 mmHg; p = 0.002). The number of patients with a mean distal esophageal contraction amplitude exceeding the 95th percentile of normal also was significantly higher in the study group (13/40 vs 5/40; p = 0.03). A total of 10 patients experienced new onset of chest pain with the Bravo capsule in place, and 6 patients experienced hypertensive esophageal contractions. CONCLUSIONS: The intraesophageal Bravo capsule can cause hypertensive esophageal contractions, which may lead to chest pain.


Asunto(s)
Dolor en el Pecho/etiología , Enfermedades del Esófago/etiología , Enfermedades del Esófago/fisiopatología , Reflujo Gastroesofágico/metabolismo , Monitoreo Fisiológico/efectos adversos , Monitoreo Fisiológico/instrumentación , Contracción Muscular , Protones , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Diseño de Equipo , Humanos , Concentración de Iones de Hidrógeno , Persona de Mediana Edad , Músculo Liso/fisiopatología
7.
Surg Endosc ; 20 Suppl 2: S462-6, 2006 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-16557420

RESUMEN

The function of the lower esophageal sphincter (LES) has historically been elucidated by two major manometric methods: the one concentrating on static parameters including resting pressure, overall length, and intraabdominal length, and the other concentrating on the episodic loss of sphincter tone, termed "transient lower esophageal sphincter relaxations" (TLESRs). Both approaches yield valuable insights, but neither is all-encompassing. Both resting characteristics and the production of TLESRs are affected by many features in the typical western diet, including carbonated beverages. The authors hypothesize that repetitive distention resulting from such substances causes the LES to become transiently defective and reduces the threshold for the occurrence of TLESRs. Long-term defects of the resting parameters may reflect secondary damage to underlying muscle caused by increased reflux. The coexistence of hiatal hernia compounds the mechanical deficiency, and obesity also may contribute. Despite much research to reduce the frequency of TLESRs pharmacologically, restoration of the LES remains primarily within the realm of the surgeon.


Asunto(s)
Esfínter Esofágico Inferior/fisiopatología , Reflujo Gastroesofágico/fisiopatología , Animales , Bebidas Gaseosas/efectos adversos , Bebidas Gaseosas/estadística & datos numéricos , Reflujo Gastroesofágico/etiología , Reflujo Gastroesofágico/cirugía , Hernia Hiatal/complicaciones , Hernia Hiatal/fisiopatología , Humanos , Manometría , Modelos Biológicos , Contracción Muscular , Obesidad/complicaciones , Obesidad/fisiopatología , Papio , Presión
8.
ANZ J Surg ; 71(11): 675-9, 2001 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11736832

RESUMEN

BACKGROUND: Uncontrolled chest wall disease due to breast cancer is a highly morbid condition causing pain, ulceration, malodour and the need for frequent dressings. Aggressive surgical approaches are rarely justified because most patients will succumb to metastatic breast cancer within a short period. A highly selected group of patients with minimal or no evidence of metastatic disease and good performance status may benefit from radical chest wall surgery. Omental transposition flaps are ideal for reconstructing extensive surgical defects following chest wall surgery. METHODS: A retrospective review was carried out of 61 female patients treated consecutively between 1980 and 1995. The surgical technique is described herein. RESULTS: All patients were symptomatic preoperatively. Symptoms included ulceration (80%), pain (44%) and malodour (40%). Twenty-nine patients had uncontrolled local recurrence following initial treatment for locally advanced breast cancer and 32 patients developed uncontrolled recurrence after treatment for operable breast cancer by mastectomy or conservation surgery. Median survival following chest wall surgery was 21 months and the median local recurrence-free interval was 20 months. Morbidity was -limited. There were no cases of major flap loss. Twenty-nine patients (48%) had no further local disease. Eighteen patients (30%) developed soft-tissue recurrence at the edge of the omental flap or in surrounding skin and 14 (23%) developed recurrence beneath the flap. CONCLUSION: In a highly selected group of patients with symptomatic uncontrolled chest wall recurrence who are fit and have an expectation of at least moderate-term survival, radical chest wall surgery and omental flap transposition offers excellent palliation and local control in the majority of patients


Asunto(s)
Neoplasias de la Mama/cirugía , Recurrencia Local de Neoplasia/cirugía , Epiplón/cirugía , Colgajos Quirúrgicos , Neoplasias de la Mama/mortalidad , Femenino , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Tiempo
9.
Arch Surg ; 136(11): 1267-73, 2001 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11695971

RESUMEN

HYPOTHESIS: Risk factors for the presence and extent of Barrett esophagus (BE) can be identified in patients with gastroesophageal reflux disease (GERD). DESIGN: Case-comparison study. SETTING: University tertiary referral center. PATIENTS: Five hundred two consecutive patients with GERD documented by 24-hour esophageal pH monitoring and with complete demographic, endoscopic, and physiological evaluation, divided in groups according to the presence and extent of BE (328 patients without BE and 174 with BE [67 short-segment BE and 107 long-segment BE]). MAIN OUTCOME MEASURES: Clinical, endoscopic, and physiological data, studied by multivariate analysis, to identify the independent predictors of the presence and extent of BE. RESULTS: Seven factors were identified as predictors of BE. They were abnormal bile reflux (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.9-9.7), hiatal hernia larger than 4 cm (OR, 4.1; 95% CI, 2.1-8.0), a defective lower esophageal sphincter (OR, 2.7; 95% CI, 1.4-5.4), male sex (OR, 2.6; 95% CI, 1.6-4.3), defective distal esophageal contraction (OR, 2.2; 95% CI, 1.4-3.5), abnormal number of reflux episodes lasting longer than 5 minutes (OR, 2.2; 95% CI, 1.1-4.6), and GERD symptoms lasting for more than 5 years (OR, 2.1; 95% CI, 1.4-3.2). Only abnormal bile reflux (OR, 4.8; 95% CI, 1.7-13.2) was identified as a predictor of short-segment BE (baseline, no BE). Three factors were identified as predictors of long-segment BE (baseline short-segment BE). They were hiatal hernia larger than 4 cm (OR, 17.8; 95% CI, 4.1-76.6), a defective lower esophageal sphincter (OR, 16.9; 95% CI, 1.6-181.4), and an abnormal longest reflux episode (OR, 8.1; 95% CI, 2.8-24.0). CONCLUSIONS: Among patients with GERD, specific factors are associated with the presence and extent of BE. Elimination of reflux with an antireflux operation in patients with 1 or more of these factors may prevent the future development of BE.


Asunto(s)
Esófago de Barrett/etiología , Reflujo Gastroesofágico/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Factores de Riesgo
10.
Surg Endosc ; 15(7): 663-6, 2001 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-11591964

RESUMEN

BACKGROUND: Although there have been case reports describing trocar site herniation after laparoscopic fundoplication, its overall prevalence and the risk factors for its development are unclear. METHODS: The records of 320 patients undergoing primary laparoscopic fundoplication as treatment for gastroesophageal reflex disease (GERD) or hiatal hernia between 1991 and 1999 were reviewed retrospectively. Placement of the initial supraumbilical trocar was by the open Hassan technique in all patients. RESULTS: Nine patients (five male) with a mean age 54 years (range, 37-75) developed trocar site herniation, for an overall prevalence of 3%. The mean interval between surgery and diagnosis was 12 months (range, 4-21). In all patients, the hernia occurred at the supraumbilical camera port site. Patients with trocar hernias tended to have a higher body mass index (BMI) than those without hernias (mean BMI, 29.4 kg/m2 vs 27.2 kg/m2, p = 0.13). None of the patients developed intestinal obstruction as a consequence of herniation. To date, all but one of the hernias have been repaired. Six of them required the insertion of a prosthetic mesh. CONCLUSIONS: The prevalence of trocar site herniation after laparoscopic fundoplication was minimal at 3%. All hernias occurred at the midline supraumbilical port, the only site where open trocar insertion was employed. As a consequence of these observations, we have developed a new method of open trocar placement. This method utilizes a paramedian skin incision and separate fascial incisions through anterior and posterior rectus sheathes, with retraction of the rectus abdominis muscle laterally.


Asunto(s)
Fundoplicación/efectos adversos , Hernia Ventral/etiología , Laparoscopía/efectos adversos , Instrumentos Quirúrgicos/efectos adversos , Abdomen/cirugía , Músculos Abdominales/cirugía , Adulto , Anciano , Femenino , Estudios de Seguimiento , Fundoplicación/métodos , Reflujo Gastroesofágico/cirugía , Hernia Hiatal/cirugía , Hernia Ventral/epidemiología , Hernia Ventral/cirugía , Humanos , Laparoscopía/métodos , Masculino , Persona de Mediana Edad , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Resultado del Tratamiento
11.
Ann Surg ; 234(4): 532-8; discussion 538-9, 2001 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11573046

RESUMEN

OBJECTIVE: To assess the long-term outcome of antireflux surgery in patients with Barrett's esophagus. SUMMARY BACKGROUND DATA: The prevalence of Barrett's esophagus is increasing, and its treatment is problematic. Antireflux surgery has the potential to stop reflux and induce a quiescent mucosa. Its long-term outcome, however, has recently been challenged with reports of poor control of reflux and the inability to prevent progression to cancer. METHODS: The outcome of antireflux surgery was studied in 97 patients with Barrett's esophagus. Follow-up was complete in 88% (85/97) at a median of 5 years. Fifty-nine had long-segment and 26 short-segment Barrett's. Patients with intestinal metaplasia of the cardia were excluded. Fifty patients underwent a laparoscopic procedure, 20 a transthoracic procedure, and 3 abdominal Nissen operations. Nine had a Collis-Belsey procedure and three had other partial wraps. Outcome measures included relief of reflux symptoms (all), patients' perception of the result (all), upper endoscopy and histology (n = 79), and postoperative 24-hour pH monitoring (n = 21). RESULTS: At a median follow-up of 5 years, reflux symptoms were absent in 67 of 85 patients (79%). Eighteen (20%) developed recurrent symptoms; four had returned to taking daily acid-suppression medication. Seven patients underwent a secondary repair and were asymptomatic, increasing the eventual successful outcome to 87%. Recurrent symptoms were most common in patients undergoing Collis-Belsey (33%) and laparoscopic Nissen (26%) procedures and least common after a transthoracic Nissen operation (5%). The results of postoperative 24-hour pH monitoring were normal in 17 of 21 (81%). Recurrent hiatal hernias were detected in 17 of 79 patients studied; 6 were asymptomatic. Seventy-seven percent of the patients considered themselves cured, 22% considered their condition to be improved, and 97% were satisfied. Low-grade dysplasia regressed to nondysplastic Barrett's in 7 of 16 (44%), and intestinal metaplasia regressed to cardiac mucosa in 9 of 63 (14%). Low-grade dysplasia developed in 4 of 63 (6%) patients. No patient developed high-grade dysplasia or cancer in 410 patient-years of follow-up. CONCLUSIONS: After antireflux surgery, most patients with Barrett's enjoy long-lasting relief of reflux symptoms, and nearly all patients consider themselves cured or improved. Mild symptoms recur in one fifth. Importantly, dysplasia regressed in nearly half of the patients in whom it was present before surgery, intestinal metaplasia disappeared in 14% of patients, and high-grade dysplasia and adenocarcinoma were prevented in all.


Asunto(s)
Esófago de Barrett/diagnóstico , Esófago de Barrett/cirugía , Fundoplicación/métodos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biopsia con Aguja , Distribución de Chi-Cuadrado , Endoscopía del Sistema Digestivo , Femenino , Estudios de Seguimiento , Humanos , Concentración de Iones de Hidrógeno , Laparoscopía/métodos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Periodo Posoperatorio , Estudios Prospectivos , Recurrencia , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Resultado del Tratamiento
12.
Int Nurs Rev ; 48(2): 86-92, 2001 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-11407467

RESUMEN

This report describes the evaluation of a curriculum-integrated programme designed to help students develop an awareness of the nursing literature, the skills to locate and retrieve it, and skills required in its evaluation; in other words'information literacy'. Positive changes in student performance on objective measures of information-literacy skills were revealed as well as a significant increase in the levels of confidence of the student in performing those skills. Students who had undertaken the information-literacy programme ('programme' students) performed better on a range of objective measures of information literacy, as well as reporting higher levels of confidence in these skills, than students who had not participated in the programme ('non-programme' students). Evaluation of this programme provides evidence of the potential usefulness of a curriculum-integrated approach for the development of information-literacy skills within nursing education. With these underlying skills, students will be better equipped to consolidate and extend their key information-literacy skills to include research appreciation and application. These are vital for effective lifelong learning and a prerequisite to evidence-based practice.


Asunto(s)
Educación en Enfermería , Medicina Basada en la Evidencia , Evaluación Educacional , Humanos , Nueva Gales del Sur , Evaluación de Programas y Proyectos de Salud , Autoevaluación (Psicología) , Enseñanza/métodos
13.
Ann Surg ; 233(4): 588-93, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11303143

RESUMEN

OBJECTIVE: To examine the historical evidence that the thyroidectomy performed on operatic soprano Amelita Galli-Curci was responsible for the abrupt termination of her career. SUMMARY BACKGROUND DATA: The superior laryngeal branch of the vagus nerve may be injured during thyroidectomy, producing vocal defects more subtle than those found after recurrent nerve injury. It is widely believed that Galli-Curci suffered superior laryngeal nerve injury during her thyroidectomy by Arnold Kegel, MD, in 1935, resulting in the termination of her career. METHODS: The authors examined contemporary press reviews after surgery, conducted interviews with colleagues and relatives of the surgeon, and compared the career of Galli-Curci with that of other singers. RESULTS: Evidence against the prevailing view is to be found in the fact that she continued to perform acceptably after surgery, her continued friendly relationship with the surgeon for years afterward, the absence of the typical effects of superior laryngeal nerve injury, and the presence of other explanations for the gradual decline in her vocal abilities (documentation of deterioration before surgery, physiologic changes in the larynx comparable to those found in most other famous sopranos who retire at about the same age or earlier, and the possible development of myxedema). CONCLUSIONS: The story should no longer be perpetuated in surgical textbooks and papers.


Asunto(s)
Personajes , Traumatismos del Nervio Laríngeo , Música/historia , Tiroidectomía/historia , Femenino , Historia del Siglo XIX , Historia del Siglo XX , Humanos , Complicaciones Intraoperatorias , Italia , Tiroidectomía/efectos adversos , Estados Unidos
14.
Surgery ; 129(3): 267-76, 2001 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11231454

RESUMEN

BACKGROUND: Expression levels of the retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma) are significantly different in neoplastic tissues compared with non-neoplastic tissues for some tumors. This study investigated whether retinoic acid receptor messenger RNA (mRNA) expression levels are altered in Barrett's esophagus and Barrett's adenocarcinoma tissues. METHODS: Relative mRNA expression levels of the RARs were quantified by using the ABI 7700 Sequence Detector (Taqman) system in Barrett's intestinal metaplasia (n = 15), dysplasia (n = 6), adenocarcinoma (n = 17), and matching normal esophagus tissues (n = 36). RESULTS: RAR-alpha expression was significantly increased, and RAR-gamma expression was significantly decreased, at higher stages in the Barrett's sequence. There was almost complete loss of RAR-gamma expression (relative expression level < or = 1) in a majority (70%) of the dysplasia and adenocarcinoma tissues. There were significant differences in RAR-alpha and RAR-gamma expression in histopathologically normal tissues in patients with cancer versus patients without cancer. RAR-beta expression levels were significantly elevated in adenocarcinoma versus normal esophagus tissues. The RAR expression profile was similar for cancers arising within the esophagus and for cancers arising at the gastroesophageal junction. CONCLUSIONS: RAR mRNA expression levels are significantly different in Barrett's tissues compared with normal esophagus tissues, and these levels are significantly different in Barrett's dysplasia and adenocarcinoma tissues compared with nondysplastic tissues. These results suggest that RAR mRNA levels may be useful biomarkers for this disease and that gastroesophageal junction adenocarcinomas are genetically similar to esophageal adenocarcinomas. These results also suggest that a cancer field is present in the esophagus in patients with cancer and that genetic alterations can precede histopathologic alterations in this disease.


Asunto(s)
Adenocarcinoma/metabolismo , Esófago de Barrett/metabolismo , Esófago de Barrett/patología , Neoplasias Esofágicas/metabolismo , Intestinos/patología , Receptores de Ácido Retinoico/metabolismo , Unión Esofagogástrica , Esófago/metabolismo , Humanos , Metaplasia , ARN Mensajero/metabolismo , Receptores de Ácido Retinoico/antagonistas & inhibidores , Receptores de Ácido Retinoico/genética , Valores de Referencia , Receptor alfa de Ácido Retinoico , Receptor de Ácido Retinoico gamma
15.
Semin Laparosc Surg ; 8(4): 265-71, 2001 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11813144

RESUMEN

The pathophysiologic hallmark of gastroesophageal reflux disease is loss of the physical barrier at the gastroesophageal junction (GEJ). In recent years, endoscopic techniques that augment or enhance the barrier have emerged. The various techniques include the injection of polymers at the GEJ, delivery of radiofrequency energy to the cardia, and by simple suturing or plication the gastroesophageal junction endoscopically. Results show significant symptomatic improvement, reduction in antacid medication usage, improvement in patient satisfaction, and modest reductions in esophageal acid exposure. Safety, feasibility, and efficacy have been shown with these endoscopic techniques. Future refinements and improvements are expected in this emerging field.


Asunto(s)
Endoscopía , Reflujo Gastroesofágico/terapia , Polímeros/administración & dosificación , Prótesis e Implantes , Unión Esofagogástrica , Humanos , Inyecciones/métodos
16.
Nurse Educ Pract ; 1(1): 1-2, 2001 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-19036235
17.
Am Surg ; 66(11): 1083-4, 2000 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11090026

RESUMEN

Mallory-Weiss Syndrome (MWS) lesions account for up to 15 per cent of upper gastrointestinal bleeding episodes. Typically these lesions present as a consequence of vomiting that is often associated with alcoholism. Recently other conditions such as pregnancy, migraine, hiatal hernia, gastric ulcer, biliary disease, and various medications have been associated with MWS. We report on a 32-year-old male who developed a MSW lesion after a prolonged period of swimming followed by an extended commercial airplane flight. The hemodynamic changes associated with swimming (increased central distribution of blood volume) and the pressure changes in commercial aircraft (a reduction of 0.3 atmospheres of pressure) are discussed. We conclude that the combination of these factors contributed to the development of a MWS lesion and gastrointestinal bleeding in this patient. We recommend that both air travel and athletic activities be considered as possible contributing factors in the evaluation of the cause of new-onset gastrointestinal bleeding.


Asunto(s)
Altitud , Síndrome de Mallory-Weiss/etiología , Natación , Adulto , Medicina Aeroespacial , Humanos , Masculino , Factores de Tiempo
18.
Nurse Educ Today ; 20(6): 485-9, 2000 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10959137

RESUMEN

This paper describes an evaluation of a curriculum-integrated information literacy programme in an undergraduate nursing course. The aim of the programme was to provide students with an awareness of the discipline's literature and the skills to locate and retrieve the literature. A multidimensional process for determining nursing students' development was utilised in the evaluation of the programme. Pre- and post-programme questionnaires were distributed to a cohort of students who undertook the programme. A cohort of more senior students who had not undertaken the information literacy programme was utilised as a comparison group. Questionnaire results were analysed using a range of inferential statistics. This paper will focus on two main findings related to objective measures of information literacy skills. These include pre-programme/post-programme change in student performance and differences in student performance between those who undertook the programme and those who did not. The programme demonstrated its effectiveness in developing information literacy skills, however the challenge remains for both academics and students to ensure that these skills are consolidated and extended for effective life-long learning.


Asunto(s)
Alfabetización Digital , Capacitación de Usuario de Computador/métodos , Bachillerato en Enfermería/organización & administración , Almacenamiento y Recuperación de la Información , Informática Aplicada a la Enfermería/educación , Catálogos de Biblioteca , Capacitación de Usuario de Computador/normas , Curriculum , Evaluación Educacional , Humanos , Almacenamiento y Recuperación de la Información/métodos , Almacenamiento y Recuperación de la Información/normas , Modelos Educacionales , Modelos de Enfermería , Nueva Gales del Sur , Investigación en Educación de Enfermería , Competencia Profesional/normas , Evaluación de Programas y Proyectos de Salud , Encuestas y Cuestionarios
20.
J Am Coll Surg ; 190(5): 553-60; discussion 560-1, 2000 May.
Artículo en Inglés | MEDLINE | ID: mdl-10801022

RESUMEN

BACKGROUND: Recent studies based on symptomatic outcomes analyses have shown that laparoscopic repair of large type III hiatal hernias is safe, successful, and equivalent to open repair. These outcomes analyses were based on a relatively short followup period and lack objective confirmation that the hernia has not recurred. The aim of this study was to compare the outcomes of laparoscopic and open repair of large type III hiatal hernia using both symptomatic evaluation and barium study to assess the integrity of the repair. STUDY DESIGN: Fifty-four patients underwent repair of a large type III hiatal hernia between 1985 and 1998. The surgical approach was laparotomy in 13, thoracotomy in 14, and laparoscopy in 27. An antireflux procedure was included in all patients. Symptomatic outcomes were assessed using a structured questionnaire at a median of 24 months and was complete in 51 of 54 patients (94%). A single radiologist, without knowledge of the operative procedure, assessed the integrity of the repair using video esophagram. Videos were performed at a median of 27 months (35 months open and 17 laparoscopic) and were completed in 41 of 54 patients (75%). RESULTS: Symptomatic outcomes were similar in both groups with excellent or good outcomes in 76% of the patients after laparoscopic repair and 88% after an open repair. Reherniation was present in 12 patients and was asymptomatic in 7. A recurrent hernia was present in 12 of the 41 patients (29%) who returned for a followup video esophagram. Forty-two percent (9 of 21) of the laparoscopic group had a recurrent hernia compared with 15% (3 of 20) of the open group (p < 0.001 log-rank value on recurrence-free followup). CONCLUSIONS: Laparoscopic repair of type III hiatal hernias is associated with a disturbingly high (42%) prevalence of recurrent hernia. More than half such recurrences have few, if any, symptoms.


Asunto(s)
Hernia Hiatal/cirugía , Laparoscopía , Adulto , Anciano , Anciano de 80 o más Años , Procedimientos Quirúrgicos Electivos , Esófago/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Hernia Hiatal/clasificación , Hernia Hiatal/diagnóstico por imagen , Humanos , Laparoscopía/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Radiografía , Recurrencia , Factores de Tiempo , Resultado del Tratamiento , Grabación en Video
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA