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Bioorg Med Chem Lett
; 19(15): 4207-9, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19524438
RESUMEN
A series of 5-N,N-disubstituted-5-aminopyrazole-3-carboxylic acids were prepared and found to act as highly potent and selective agonists of the G-Protein Coupled Receptor (GPCR) GPR109b, a low affinity receptor for niacin and some aromatic d-amino acids. Little activity was observed at the highly homologous higher affinity niacin receptor, GPR109a.
